ENSGALG00000034716


Gallus gallus

Features
Gene ID: ENSGALG00000034716
  
Biological name :HEY2
  
Synonyms : hes related family bHLH transcription factor with YRPW motif 2 / HEY2
  
Possible biological names infered from orthology : Hairy/enhancer-of-split related with YRPW motif protein 2 / Q9QUS4 / Q9UBP5
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 60044511
Gene end: 60053824
  
Corresponding Affymetrix probe sets: GgaAffx.9430.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057141
NCBI entrez gene - 421718     See in Manteia.
RefSeq - XM_015284442
swissprot - A0A1D5PW12
Ensembl - ENSGALG00000034716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hey2ENSDARG00000013441Danio rerio
 HEY2ENSG00000135547Homo sapiens
 Hey2ENSMUSG00000019789Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HEYL / hes related family bHLH transcription factor with YRPW motif-like / Q9DBX7* / Q9NQ87* / Hairy/enhancer-of-split related with YRPW motif-like protein *ENSGALG0000004473738
HEY1 / hes related family bHLH transcription factor with YRPW motif 1 / Q9Y5J3*ENSGALG0000003503131


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0003150 muscular septum morphogenesis IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003171 atrioventricular valve development IEA
 biological_processGO:0003184 pulmonary valve morphogenesis IEA
 biological_processGO:0003186 tricuspid valve morphogenesis IEA
 biological_processGO:0003195 tricuspid valve formation IEA
 biological_processGO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation IEA
 biological_processGO:0003208 cardiac ventricle morphogenesis IEA
 biological_processGO:0003214 cardiac left ventricle morphogenesis IEA
 biological_processGO:0003215 cardiac right ventricle morphogenesis IEA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IEA
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0009948 anterior/posterior axis specification IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0014031 mesenchymal cell development IEA
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:0035910 ascending aorta morphogenesis IEA
 biological_processGO:0035912 dorsal aorta morphogenesis IEA
 biological_processGO:0036304 umbilical cord morphogenesis IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045607 regulation of inner ear auditory receptor cell differentiation IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0055015 ventricular cardiac muscle cell development IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IEA
 biological_processGO:0060347 heart trabecula formation IEA
 biological_processGO:0060411 cardiac septum morphogenesis IEA
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060413 atrial septum morphogenesis IEA
 biological_processGO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0060840 artery development IEA
 biological_processGO:0060842 arterial endothelial cell differentiation IEA
 biological_processGO:0060948 cardiac vascular smooth muscle cell development IEA
 biological_processGO:0060977 coronary vasculature morphogenesis IEA
 biological_processGO:0061156 pulmonary artery morphogenesis IEA
 biological_processGO:0065004 protein-DNA complex assembly IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:0097084 vascular smooth muscle cell development IEA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IEA
 biological_processGO:2001212 regulation of vasculogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016580 Sin3 complex IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0035939 microsatellite binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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