ENSMUSG00000044548


Mus musculus

Features
Gene ID: ENSMUSG00000044548
  
Biological name :Dact1
  
Synonyms : Dact1 / Dapper homolog 1 / Q8R4A3
  
Possible biological names infered from orthology : dishevelled binding antagonist of beta catenin 1 / Q9NYF0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 71309884
Gene end: 71320107
  
Corresponding Affymetrix probe sets: 10396270 (MoGene1.0st)   1417937_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058943
Ensembl peptide - ENSMUSP00000117169
NCBI entrez gene - 59036     See in Manteia.
MGI - MGI:1891740
RefSeq - NM_001190466
RefSeq - NM_021532
RefSeq Peptide - NP_001177395
RefSeq Peptide - NP_067507
swissprot - Q8R4A3
swissprot - D3Z5V0
Ensembl - ENSMUSG00000044548
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dact1ENSDARG00000101635Danio rerio
 DACT1ENSGALG00000012023Gallus gallus
 DACT1ENSG00000165617Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dact2 / Q7TN08 / Dapper homolog 2 / Q5SW24* / dishevelled binding antagonist of beta catenin 2*ENSMUSG0000004882625


Protein motifs (from Interpro)
Interpro ID Name
 IPR024843  Dapper
 IPR024848  Dact1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0048619 embryonic hindgut morphogenesis IMP
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IEA
 biological_processGO:1904864 negative regulation of beta-catenin-TCF complex assembly IEA
 biological_processGO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway IMP
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030877 beta-catenin destruction complex IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0005080 protein kinase C binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0051018 protein kinase A binding IEA
 molecular_functionGO:0070097 delta-catenin binding IDA


Pathways (from Reactome)
Pathway description
Degradation of DVL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: T/tks1
Genetic Background: Not Specified

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc
Genetic Background: involves: 129

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Sestd1tm1.1Bnrc/Sestd1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002769 abnormal vas deferens morphology "malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0002861 abnormal tail bud morphology "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002990 short ureter "reduced length of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0003126 abnormal vulva morphology "anomaly in the structure of the external genitalia of the female" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0003445 sirenomelia "fusion of the posterior limbs often with partial or complete fusion of the autopods" [J:67375]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0003535 absent vagina "absence of the female reproductive canal located between the uterus and the vulva" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0003537 hydrometrocolops "collection of fluid in the vagina; often due to a congenital obstruction" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0003591 urethra atresia "closure, or failure to develop a connection in the canal that leads from the bladder and discharges urine externally" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0003604 single kidney 
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0003605 fused kidneys 
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0004710 small notochord "reduced size of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0004714 truncated notochord "notochord morphology that terminates abruptly as if having an end or point cut off" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc
Genetic Background: involves: 129

 MP:0005034 abnormal anus morphology "structural anomaly of the lower opening of the digestive tract" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0005354 abnormal ilium morphology "structural anomaly of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

 MP:0008786 abnormal hindgut morphology "any structural anomaly of the caudal portion of the primitive digestive tube of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0008787 abnomal tailgut morphology "any structural anomaly of the extension of the hindgut of the primitive digestive tube of the embryo, caudal to the location of the anal opening" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008999 absent anus "absence of the lower opening of the digestive tract" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0009084 blind uterus "presence of a female muscular organ of gestation that ends in a blind segment or sac and does not communicate with the cevix or vagina" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0009199 abnormal external male genitalia morphology "any structural anomaly of the external masculine genital organs, including the penis and scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0009204 absent external male genitalia "absence of the external masculine genital organs, including the penis and scrotum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0009211 absent external female genitalia "absence of the external feminine genital organs, collectively known as the vulva" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0009252 absent urinary bladder "absence of the inflatable musculomembranous bag for holding urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc
Genetic Background: involves: 129

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0009709 hydrometra "an accumulation in the uterine lumen of normal secretions that ordinarily drain from the body but are retained when the cervix or vagina is significantly or completely closed" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfn2tm2Dcc/Mfn2tm2Dcc
Genetic Background: involves: 129S/SvEv

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc
Genetic Background: involves: 129

 MP:0010115 abnormal embryonic cloaca morphology "any strucutral anomaly of the endoderm-lined chamber into which the hidgut and allantois empty in early embryos" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0010116 abnormal primitive urogenital sinus morphology "any structural anomaly of the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0011298 ureter hypoplasia "underdevelopment or reduced size of the ureter, usually due to a reduced number of cells" [MGI:anna]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0011771 abnormal genital tubercle morphology "any structural anomaly of the embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until approximately E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation" [MGI:anna]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc
Genetic Background: involves: 129

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Sestd1tm1.1Bnrc/Sestd1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0011797 blind ureter "a ureter ending in a blind-ended segment or pouch" [MGI:anna]
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Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0012182 abnormal presomitic mesoderm morphology "any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dact1tm1Yegc/Dact1tm1Yegc
Genetic Background: B6.129-Dact1tm1Yegc

 MP:0013217 abnormal posterior definitive endoderm morphology "any structural anomaly of the posterior region of the definitive endoderm which evolves into the midgut and hindgut, which will eventually differentiate into the large and small intestine" [PMID:0080555950]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / reaction / complex






 

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