ENSMUSG00000048826


Mus musculus

Features
Gene ID: ENSMUSG00000048826
  
Biological name :Dact2
  
Synonyms : Dact2 / Dapper homolog 2 / Q7TN08
  
Possible biological names infered from orthology : dishevelled binding antagonist of beta catenin 2 / Q5SW24
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A2
Gene start: 14195231
Gene end: 14203831
  
Corresponding Affymetrix probe sets: 10447938 (MoGene1.0st)   1437929_at (Mouse Genome 430 2.0 Array)   1440942_at (Mouse Genome 430 2.0 Array)   1443973_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051638
NCBI entrez gene - 240025     See in Manteia.
MGI - MGI:1920347
RefSeq - NM_172826
RefSeq Peptide - NP_766414
swissprot - Q7TN08
Ensembl - ENSMUSG00000048826
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dact2ENSDARG00000056986Danio rerio
 DACT2ENSGALG00000011288Gallus gallus
 DACT2ENSG00000164488Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dact1 / Q8R4A3 / Dapper homolog 1 / Q9NYF0* / dishevelled binding antagonist of beta catenin 1*ENSMUSG0000004454827


Protein motifs (from Interpro)
Interpro ID Name
 IPR024843  Dapper
 IPR024853  Dact2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IGI
 biological_processGO:0003382 epithelial cell morphogenesis IMP
 biological_processGO:0007162 negative regulation of cell adhesion IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0043588 skin development IMP
 biological_processGO:0072061 inner medullary collecting duct development IMP
 biological_processGO:1900108 negative regulation of nodal signaling pathway IMP
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0005080 protein kinase C binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0051018 protein kinase A binding IDA
 molecular_functionGO:0070097 delta-catenin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
Show

Allelic Composition: Apptm1Dbo/App+,Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0011239 abnormal skin coloration "a variation in an expected skin color or complexion that may be due to inflammation, pigment defects or other causes" [MGI:llw2]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0012193 increased keratinocyte migration "increased or faster movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
Show

Allelic Composition: Apptm1Dbo/App+,Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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