ENSMUSG00000022580


Mus musculus

Features
Gene ID: ENSMUSG00000022580
  
Biological name :Rhpn1
  
Synonyms : Q61085 / Rhophilin-1 / Rhpn1
  
Possible biological names infered from orthology : Q8TCX5 / rhophilin Rho GTPase binding protein 1
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D3
Gene start: 75704280
Gene end: 75715485
  
Corresponding Affymetrix probe sets: 10424711 (MoGene1.0st)   1450789_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023244
Ensembl peptide - ENSMUSP00000113042
Ensembl peptide - ENSMUSP00000116837
NCBI entrez gene - 14787     See in Manteia.
MGI - MGI:1098783
RefSeq - XM_006520447
RefSeq - NM_001163465
RefSeq - NM_008164
RefSeq Peptide - NP_001156937
RefSeq Peptide - NP_032190
swissprot - Q61085
swissprot - Q80WU2
swissprot - E9Q7Q7
Ensembl - ENSMUSG00000022580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhpn1ENSDARG00000052454Danio rerio
 RHPN1ENSGALG00000034337Gallus gallus
 RHPN1ENSG00000158106Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rhpn2 / Q8BWR8 / Rhophilin-2 / Q8IUC4* / rhophilin Rho GTPase binding protein 2*ENSMUSG0000003049444
Ptpn23 / Q6PB44 / Tyrosine-protein phosphatase non-receptor type 23 / Q9H3S7* / protein tyrosine phosphatase, non-receptor type 23*ENSMUSG0000003605719
Q9WU78 / Pdcd6ip / Programmed cell death 6-interacting protein / Q8WUM4*ENSMUSG0000003250418


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR004328  BRO1 domain
 IPR011072  HR1 rho-binding domain
 IPR036034  PDZ superfamily
 IPR036274  HR1 repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030695 GTPase regulator activity IPI


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Rhotekin and Rhophilins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022832 Ropn1 / Q9ESG2 / Ropporin-1 / Q9HAT0* / ROPN1B* / Q9BZX4* / rhophilin associated tail protein 1* / rhophilin associated tail protein 1B*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction






 

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