ENSMUSG00000032504


Mus musculus

Features
Gene ID: ENSMUSG00000032504
  
Biological name :Pdcd6ip
  
Synonyms : Pdcd6ip / Programmed cell death 6-interacting protein / Q9WU78
  
Possible biological names infered from orthology : Q8WUM4
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 113651744
Gene end: 113708259
  
Corresponding Affymetrix probe sets: 10597354 (MoGene1.0st)   1415937_s_at (Mouse Genome 430 2.0 Array)   1426184_a_at (Mouse Genome 430 2.0 Array)   1448155_at (Mouse Genome 430 2.0 Array)   1449674_s_at (Mouse Genome 430 2.0 Array)   1460263_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035086
Ensembl peptide - ENSMUSP00000107492
NCBI entrez gene - 18571     See in Manteia.
MGI - MGI:1333753
RefSeq - XM_011242941
RefSeq - NM_001164677
RefSeq - NM_001164678
RefSeq - NM_011052
RefSeq Peptide - NP_001158150
RefSeq Peptide - NP_035182
RefSeq Peptide - NP_001158149
swissprot - Q9WU78
Ensembl - ENSMUSG00000032504
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdcd6ipENSDARG00000025269Danio rerio
 PDCD6IPENSGALG00000033500Gallus gallus
 Q8WUM4ENSG00000170248Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptpn23 / Q6PB44 / Tyrosine-protein phosphatase non-receptor type 23 / Q9H3S7* / protein tyrosine phosphatase, non-receptor type 23*ENSMUSG0000003605726
Rhpn1 / Q61085 / Rhophilin-1 / Q8TCX5* / rhophilin Rho GTPase binding protein 1*ENSMUSG0000002258013
Rhpn2 / Q8BWR8 / Rhophilin-2 / Q8IUC4* / rhophilin Rho GTPase binding protein 2*ENSMUSG0000003049413


Protein motifs (from Interpro)
Interpro ID Name
 IPR004328  BRO1 domain
 IPR025304  ALIX V-shaped domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis ISO
 biological_processGO:0000915 actomyosin contractile ring assembly IMP
 biological_processGO:0000920 cell separation after cytokinesis ISO
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010824 regulation of centrosome duplication ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0039702 viral budding via host ESCRT complex ISO
 biological_processGO:0045199 maintenance of epithelial cell apical/basal polarity IMP
 biological_processGO:0046755 viral budding ISO
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070830 bicellular tight junction assembly IMP
 biological_processGO:0090559 regulation of membrane permeability IMP
 biological_processGO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway ISO
 biological_processGO:1903543 positive regulation of exosomal secretion ISO
 biological_processGO:1903551 regulation of extracellular exosome assembly ISO
 biological_processGO:1903553 positive regulation of extracellular exosome assembly ISO
 cellular_componentGO:0001772 immunological synapse ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042641 actomyosin IDA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0070971 endoplasmic reticulum exit site ISO
 cellular_componentGO:0090543 Flemming body ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031871 proteinase activated receptor binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046983 protein dimerization activity IPI
 molecular_functionGO:0048306 calcium-dependent protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0002285 abnormal tracheal ciliated epithelium morphology "structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0010152 abnormal brain ependyma morphology "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0011056 abnormal brain ependyma motile cilium morphology "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0011069 abnormal brain ependyma motile cilium physiology "any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0013907 abnormal cerebrospinal fluid flow "any anomaly in the dynamic process by which CSF circulates from the sites of secretion to the sites of absorption according to a unidirectional rostrocaudal flow in ventricular cavities and a multidirectional flow in subarachnoid spaces; CSF produced by the choroid plexuses in the lateral ventricles travels through interventricular foramina to the third ventricle, and then the fourth ventricle via the cerebral aqueduct and finally to the subarachnoid spaces via the median aperture (foramen of Magendie) of the fourth ventricle; in the cranial subarachnoid space, CSF circulates rostrally to the villous sites of absorption or caudally to the spinal subarachnoid space; CSF circulation through the ventricular system is driven by motile cilia on ependymal cells of the brain; CSF flow is pulsatile, corresponding to the systolic pulse wave in choroidal arteries; additional factors such as respiratory waves, the subject s posture, jugular venous pressure and physical effort also modulate CSF flow dynamics and pressure" [MGI:Anna, PMID:22100360, PMID:24229449]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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