ENSMUSG00000036057


Mus musculus

Features
Gene ID: ENSMUSG00000036057
  
Biological name :Ptpn23
  
Synonyms : Ptpn23 / Q6PB44 / Tyrosine-protein phosphatase non-receptor type 23
  
Possible biological names infered from orthology : protein tyrosine phosphatase, non-receptor type 23 / Q9H3S7
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F2
Gene start: 110385082
Gene end: 110408213
  
Corresponding Affymetrix probe sets: 10597136 (MoGene1.0st)   1427128_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142930
Ensembl peptide - ENSMUSP00000039580
NCBI entrez gene - 104831     See in Manteia.
MGI - MGI:2144837
RefSeq - NM_001081043
RefSeq - XM_011242931
RefSeq Peptide - NP_001074512
swissprot - A0A0G2JEW5
swissprot - Q6PB44
Ensembl - ENSMUSG00000036057
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn23aENSDARG00000070124Danio rerio
 PTPN23ENSGALG00000038522Gallus gallus
 PTPN23ENSG00000076201Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WU78 / Pdcd6ip / Programmed cell death 6-interacting protein / Q8WUM4*ENSMUSG0000003250413
Rhpn2 / Q8BWR8 / Rhophilin-2 / Q8IUC4* / rhophilin Rho GTPase binding protein 2*ENSMUSG000000304948
Rhpn1 / Q61085 / Rhophilin-1 / Q8TCX5* / rhophilin Rho GTPase binding protein 1*ENSMUSG000000225807


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR004328  BRO1 domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR025304  ALIX V-shaped domain
 IPR028770  Tyrosine-protein phosphatase non-receptor type 23
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0032456 endocytic recycling IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
 biological_processGO:0045022 early endosome to late endosome transport IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0061357 positive regulation of Wnt protein secretion IEA
 biological_processGO:1903387 positive regulation of homophilic cell adhesion IEA
 biological_processGO:1903393 positive regulation of adherens junction organization IEA
 biological_processGO:2000643 positive regulation of early endosome to late endosome transport IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-p/Tyrc
Genetic Background: Not Specified

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tyrc-p/Tyrc
Genetic Background: Not Specified

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr