ENSG00000076201


Homo sapiens

Features
Gene ID: ENSG00000076201
  
Biological name :PTPN23
  
Synonyms : protein tyrosine phosphatase, non-receptor type 23 / PTPN23 / Q9H3S7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.31
Gene start: 47381011
Gene end: 47413441
  
Corresponding Affymetrix probe sets: 223149_s_at (Human Genome U133 Plus 2.0 Array)   223150_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473266
Ensembl peptide - ENSP00000265562
Ensembl peptide - ENSP00000396328
NCBI entrez gene - 25930     See in Manteia.
OMIM - 606584
RefSeq - XM_005265031
RefSeq - NM_001304482
RefSeq - NM_015466
RefSeq Peptide - NP_001291411
RefSeq Peptide - NP_056281
swissprot - Q9H3S7
swissprot - R4GMM7
swissprot - C9JD91
Ensembl - ENSG00000076201
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn23aENSDARG00000070124Danio rerio
 PTPN23ENSGALG00000038522Gallus gallus
 Ptpn23ENSMUSG00000036057Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8WUM4 / PDCD6IP / programmed cell death 6 interacting proteinENSG0000017024814
RHPN1 / Q8TCX5 / rhophilin Rho GTPase binding protein 1ENSG000001581068
RHPN2 / Q8IUC4 / rhophilin Rho GTPase binding protein 2ENSG000001319418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR004328  BRO1 domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR025304  ALIX V-shaped domain
 IPR028770  Tyrosine-protein phosphatase non-receptor type 23
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0032456 endocytic recycling IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
 biological_processGO:0045022 early endosome to late endosome transport IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0061357 positive regulation of Wnt protein secretion IMP
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 biological_processGO:1903387 positive regulation of homophilic cell adhesion IMP
 biological_processGO:1903393 positive regulation of adherens junction organization IMP
 biological_processGO:2000643 positive regulation of early endosome to late endosome transport IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-37 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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