ENSMUSG00000003872


Mus musculus

Features
Gene ID: ENSMUSG00000003872
  
Biological name :Lin7b
  
Synonyms : B / Lin7b / O88951
  
Possible biological names infered from orthology : lin-7 homolog B, crumbs cell polarity complex component / Q9HAP6
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45367891
Gene end: 45370583
  
Corresponding Affymetrix probe sets: 10563253 (MoGene1.0st)   1418683_at (Mouse Genome 430 2.0 Array)   1439239_at (Mouse Genome 430 2.0 Array)   1439240_x_at (Mouse Genome 430 2.0 Array)   1449172_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147294
Ensembl peptide - ENSMUSP00000003971
NCBI entrez gene - 22342     See in Manteia.
MGI - MGI:1330858
RefSeq - NM_011698
RefSeq Peptide - NP_035828
swissprot - A0A1B0GQX6
swissprot - O88951
Ensembl - ENSMUSG00000003872
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lin7bENSDARG00000037932Danio rerio
 LIN7BENSG00000104863Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C / Lin7c / O88952 / Q9NUP9* / lin-7 homolog C, crumbs cell polarity complex component*ENSMUSG0000002716281
Lin7a / Q8JZS0 / lin-7 homolog A (C. elegans) / O14910* / lin-7 homolog A, crumbs cell polarity complex component*ENSMUSG0000001990675
Gopc / Q8BH60 / golgi associated PDZ and coiled-coil motif containing / AL132671.2*ENSMUSG0000001986129
Sntb1 / Q99L88 / Beta-1-syntrophin / Q13884* / syntrophin beta 1*ENSMUSG0000006042928
Snta1 / Q61234 / Alpha-1-syntrophin / Q13424* / syntrophin alpha 1*ENSMUSG0000002748826
Sntb2 / Q61235 / syntrophin, basic 2 / Q13425* / syntrophin beta 2*ENSMUSG0000004130825
Sntg2 / Q925E0 / Gamma-2-syntrophin / Q9NY99* / syntrophin gamma 2*ENSMUSG0000002067223
Sntg1 / gamma-1-syntrophin isoform 3 / Q9NSN8* / syntrophin gamma 1*ENSMUSG0000002590920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR014775  L27 domain, C-terminal
 IPR017365  Protein lin-7
 IPR036034  PDZ superfamily
 IPR036892  L27 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007269 neurotransmitter secretion IGI
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0045199 maintenance of epithelial cell apical/basal polarity IBA
 biological_processGO:1903361 protein localization to basolateral plasma membrane IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0097025 MPP7-DLG1-LIN7 complex IBA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0097016 L27 domain binding IBA


Pathways (from Reactome)
Pathway description
Dopamine Neurotransmitter Release Cycle
RHO GTPases Activate Rhotekin and Rhophilins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lin7atm1Dsb/Lin7atm1Dsb,Lin7btm1Dsb/Lin7btm1Dsb
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Lin7btm1Dsb/Lin7btm1Dsb
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034930 Rtkn / Q8C6B2 / Rhotekin / Q9BST9*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000024897 Apba1 / B2RUJ5 / Amyloid-beta A4 protein-binding family A member 1 / Q02410* / amyloid beta precursor protein binding family A member 1*  / reaction / complex
 ENSMUSG00000031012 Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*  / reaction / complex






 

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