ENSMUSG00000024897


Mus musculus

Features
Gene ID: ENSMUSG00000024897
  
Biological name :Apba1
  
Synonyms : Amyloid-beta A4 protein-binding family A member 1 / Apba1 / B2RUJ5
  
Possible biological names infered from orthology : amyloid beta precursor protein binding family A member 1 / Q02410
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: B
Gene start: 23758876
Gene end: 23949597
  
Corresponding Affymetrix probe sets: 10462113 (MoGene1.0st)   1437940_at (Mouse Genome 430 2.0 Array)   1455369_at (Mouse Genome 430 2.0 Array)   1459605_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025830
NCBI entrez gene - 319924     See in Manteia.
MGI - MGI:1860297
RefSeq - XM_006527140
RefSeq - NM_177034
RefSeq - XM_006527139
RefSeq Peptide - NP_796008
swissprot - B2RUJ5
Ensembl - ENSMUSG00000024897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apba1aENSDARG00000103848Danio rerio
 apba1bENSDARG00000074328Danio rerio
 APBA1ENSGALG00000015111Gallus gallus
 APBA1ENSG00000107282Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apba2 / P98084 / Amyloid-beta A4 protein-binding family A member 2 / Q99767* / amyloid beta precursor protein binding family A member 2*ENSMUSG0000003051947
Apba3 / O88888 / Amyloid-beta A4 protein-binding family A member 3 / O96018* / amyloid beta precursor protein binding family A member 3*ENSMUSG0000000493132


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR030530  Amyloid beta A4 precursor protein-binding family A member 1
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0006886 intracellular protein transport IPI
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007626 locomotory behavior IGI
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0014047 glutamate secretion IGI
 biological_processGO:0014051 gamma-aminobutyric acid secretion IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0035264 multicellular organism growth IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Dopamine Neurotransmitter Release Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Abca1tm1Jdm/Abca1+
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Abca1tm1Jdm/Abca1+
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos,Angptl4tm1Akos/Angptl4tm1Akos
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Abca1tm1Jdm/Abca1+
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos,Angptl4tm1Akos/Angptl4tm1Akos
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos,Angptl4tm1Akos/Angptl4tm1Akos
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027162 C / Lin7c / O88952 / Q9NUP9* / lin-7 homolog C, crumbs cell polarity complex component*  / reaction / complex
 ENSMUSG00000019906 Lin7a / Q8JZS0 / lin-7 homolog A (C. elegans) / O14910* / lin-7 homolog A, crumbs cell polarity complex component*  / reaction / complex
 ENSMUSG00000003872 B / Lin7b / O88951 / Q9HAP6* / lin-7 homolog B, crumbs cell polarity complex component*  / reaction / complex
 ENSMUSG00000031012 Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*  / complex / reaction






 

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