ENSMUSG00000004931


Mus musculus

Features
Gene ID: ENSMUSG00000004931
  
Biological name :Apba3
  
Synonyms : Amyloid-beta A4 protein-binding family A member 3 / Apba3 / O88888
  
Possible biological names infered from orthology : amyloid beta precursor protein binding family A member 3 / O96018
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 81266960
Gene end: 81273246
  
Corresponding Affymetrix probe sets: 10365056 (MoGene1.0st)   1416182_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151384
Ensembl peptide - ENSMUSP00000151985
Ensembl peptide - ENSMUSP00000151924
Ensembl peptide - ENSMUSP00000151614
Ensembl peptide - ENSMUSP00000151423
Ensembl peptide - ENSMUSP00000050995
NCBI entrez gene - 57267     See in Manteia.
MGI - MGI:1888527
RefSeq - XM_006513907
RefSeq - NM_018758
RefSeq - XM_006513905
RefSeq - XM_006513906
RefSeq Peptide - NP_061228
swissprot - A0A1W2P837
swissprot - O88888
swissprot - A0A1W2P6Z9
swissprot - A0A1W2P6S0
swissprot - A0A1W2P7G9
Ensembl - ENSMUSG00000004931
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-40i7.5ENSDARG00000090675Danio rerio
 APBA3ENSGALG00000000740Gallus gallus
 APBA3ENSG00000011132Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apba1 / B2RUJ5 / Amyloid-beta A4 protein-binding family A member 1 / Q02410* / amyloid beta precursor protein binding family A member 1*ENSMUSG0000002489747
Apba2 / P98084 / Amyloid-beta A4 protein-binding family A member 2 / Q99767* / amyloid beta precursor protein binding family A member 2*ENSMUSG0000003051944


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR030531  Amyloid beta A4 precursor protein-binding family A member 3
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0007268 chemical synaptic transmission IGI
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0043086 negative regulation of catalytic activity ISO
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0004857 enzyme inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019899 enzyme binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apba3tm1.1Ski/Apba3tm1.1Ski,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Apba3tm1.1Ski Lyz2tm1(cre)Ifo

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Apba3tm1.1Ski/Apba3tm1.1Ski,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Apba3tm1.1Ski Lyz2tm1(cre)Ifo

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Apba3tm1.1Ski/Apba3tm1.1Ski,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Apba3tm1.1Ski Lyz2tm1(cre)Ifo

 MP:0008618 decreased circulating interleukin-12 level "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Apba3tm1.1Ski/Apba3tm1.1Ski,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Apba3tm1.1Ski Lyz2tm1(cre)Ifo

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Apba3tm1.1Ski/Apba3tm1.1Ski,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Apba3tm1.1Ski Lyz2tm1(cre)Ifo

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: B6.129-Capn2tm1Tcs Casttm1Tcs Capn1tm1Ahc

Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apba3tm1.1Ski/Apba3tm1.1Ski,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Apba3tm1.1Ski Lyz2tm1(cre)Ifo

Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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