ENSMUSG00000030519


Mus musculus

Features
Gene ID: ENSMUSG00000030519
  
Biological name :Apba2
  
Synonyms : Amyloid-beta A4 protein-binding family A member 2 / Apba2 / P98084
  
Possible biological names infered from orthology : amyloid beta precursor protein binding family A member 2 / Q99767
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: C
Gene start: 64501706
Gene end: 64753878
  
Corresponding Affymetrix probe sets: 10553917 (MoGene1.0st)   1427288_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146279
Ensembl peptide - ENSMUSP00000032732
Ensembl peptide - ENSMUSP00000146038
Ensembl peptide - ENSMUSP00000146108
Ensembl peptide - ENSMUSP00000146269
NCBI entrez gene - 11784     See in Manteia.
MGI - MGI:1261791
RefSeq - XM_017321945
RefSeq - NM_001291166
RefSeq - NM_001291167
RefSeq - NM_007461
RefSeq - XM_006540573
RefSeq - XM_006540574
RefSeq - XM_006540576
RefSeq Peptide - NP_031487
RefSeq Peptide - NP_001278096
RefSeq Peptide - NP_001278095
swissprot - A0A0U1RPS9
swissprot - P98084
swissprot - A0A0U1RPM0
swissprot - A0A0U1RQ78
swissprot - A0A0U1RQ68
Ensembl - ENSMUSG00000030519
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apba2bENSDARG00000060639Danio rerio
 APBA2ENSGALG00000003930Gallus gallus
 APBA2ENSG00000034053Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apba1 / B2RUJ5 / Amyloid-beta A4 protein-binding family A member 1 / Q02410* / amyloid beta precursor protein binding family A member 1*ENSMUSG0000002489753
Apba3 / O88888 / Amyloid-beta A4 protein-binding family A member 3 / O96018* / amyloid beta precursor protein binding family A member 3*ENSMUSG0000000493134


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR030529  Amyloid beta A4 precursor protein-binding family A member 2
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007626 locomotory behavior IGI
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0035264 multicellular organism growth IGI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz
Genetic Background: C57BL/6-Apba2tm1Tsuz

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C3H * MRL/Mp

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-APBA2,-lacZ)1Ito/0
Genetic Background: B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-APBA2,-lacZ)1Ito/0
Genetic Background: B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-APBA2,-lacZ)1Ito/0
Genetic Background: B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz
Genetic Background: C57BL/6-Apba2tm1Tsuz

Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-APBA2,-lacZ)1Ito/0
Genetic Background: B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz
Genetic Background: C57BL/6-Apba2tm1Tsuz

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz
Genetic Background: C57BL/6-Apba2tm1Tsuz

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apba1tm1.1Sud/Apba1tm1.1Sud,Apba2tm1.1Sud/Apba2tm1.1Sud,Apba3tm1.1Sud/Apba3tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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