ENSMUSG00000019906


Mus musculus

Features
Gene ID: ENSMUSG00000019906
  
Biological name :Lin7a
  
Synonyms : Lin7a / lin-7 homolog A (C. elegans) / Q8JZS0
  
Possible biological names infered from orthology : lin-7 homolog A, crumbs cell polarity complex component / O14910
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D1
Gene start: 107271686
Gene end: 107421474
  
Corresponding Affymetrix probe sets: 10366229 (MoGene1.0st)   1435805_at (Mouse Genome 430 2.0 Array)   1438450_at (Mouse Genome 430 2.0 Array)   1456656_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020057
Ensembl peptide - ENSMUSP00000100916
Ensembl peptide - ENSMUSP00000151715
NCBI entrez gene - 108030     See in Manteia.
MGI - MGI:2135609
RefSeq - XM_006513032
RefSeq - NM_001033223
RefSeq - NM_001039354
RefSeq - NM_001284329
RefSeq - XM_006513031
RefSeq Peptide - NP_001271258
RefSeq Peptide - NP_001028395
RefSeq Peptide - NP_001034443
swissprot - Q3TUM0
swissprot - Q8JZS0
Ensembl - ENSMUSG00000019906
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lin7aENSDARG00000013414Danio rerio
 LIN7AENSGALG00000010939Gallus gallus
 LIN7AENSG00000111052Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C / Lin7c / O88952 / Q9NUP9* / lin-7 homolog C, crumbs cell polarity complex component*ENSMUSG0000002716267
B / Lin7b / O88951 / Q9HAP6* / lin-7 homolog B, crumbs cell polarity complex component*ENSMUSG0000000387267
Sntb1 / Q99L88 / Beta-1-syntrophin / Q13884* / syntrophin beta 1*ENSMUSG0000006042925
Gopc / Q8BH60 / golgi associated PDZ and coiled-coil motif containing / AL132671.2*ENSMUSG0000001986125
Snta1 / Q61234 / Alpha-1-syntrophin / Q13424* / syntrophin alpha 1*ENSMUSG0000002748824
Sntb2 / Q61235 / syntrophin, basic 2 / Q13425* / syntrophin beta 2*ENSMUSG0000004130823
Sntg2 / Q925E0 / Gamma-2-syntrophin / Q9NY99* / syntrophin gamma 2*ENSMUSG0000002067222
Sntg1 / gamma-1-syntrophin isoform 3 / Q9NSN8* / syntrophin gamma 1*ENSMUSG0000002590919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR014775  L27 domain, C-terminal
 IPR017365  Protein lin-7
 IPR036034  PDZ superfamily
 IPR036892  L27 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007269 neurotransmitter secretion IGI
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0045199 maintenance of epithelial cell apical/basal polarity IBA
 biological_processGO:0048489 synaptic vesicle transport IMP
 biological_processGO:0048839 inner ear development IDA
 biological_processGO:1903361 protein localization to basolateral plasma membrane IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IBA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0097025 MPP7-DLG1-LIN7 complex IBA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0097016 L27 domain binding IEA


Pathways (from Reactome)
Pathway description
Dopamine Neurotransmitter Release Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: LnpkUl/Lnpk+
Genetic Background: involves: 101/H * C3H/HeJ * C57BL/6J

Allelic Composition: Lin7atm1Dsb/Lin7atm1Dsb,Lin7btm1Dsb/Lin7btm1Dsb
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024897 Apba1 / B2RUJ5 / Amyloid-beta A4 protein-binding family A member 1 / Q02410* / amyloid beta precursor protein binding family A member 1*  / complex / reaction
 ENSMUSG00000031012 Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*  / complex / reaction






 

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