ENSMUSG00000027488


Mus musculus

Features
Gene ID: ENSMUSG00000027488
  
Biological name :Snta1
  
Synonyms : Alpha-1-syntrophin / Q61234 / Snta1
  
Possible biological names infered from orthology : Q13424 / syntrophin alpha 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 154376313
Gene end: 154408099
  
Corresponding Affymetrix probe sets: 10488762 (MoGene1.0st)   1416825_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105350
Ensembl peptide - ENSMUSP00000028991
NCBI entrez gene - 20648     See in Manteia.
MGI - MGI:101772
RefSeq - NM_009228
RefSeq Peptide - NP_033254
swissprot - A2AKD7
swissprot - Q61234
Ensembl - ENSMUSG00000027488
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SNTA1ENSDARG00000098420Danio rerio
 SNTA1ENSGALG00000029694Gallus gallus
 SNTA1ENSG00000101400Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sntb1 / Q99L88 / Beta-1-syntrophin / Q13884* / syntrophin beta 1*ENSMUSG0000006042952
Sntb2 / Q61235 / syntrophin, basic 2 / Q13425* / syntrophin beta 2*ENSMUSG0000004130848
Sntg2 / Q925E0 / Gamma-2-syntrophin / Q9NY99* / syntrophin gamma 2*ENSMUSG0000002067228
Sntg1 / gamma-1-syntrophin isoform 3 / Q9NSN8* / syntrophin gamma 1*ENSMUSG0000002590926
Gopc / Q8BH60 / golgi associated PDZ and coiled-coil motif containing / AL132671.2*ENSMUSG0000001986114
B / Lin7b / O88951 / Q9HAP6* / lin-7 homolog B, crumbs cell polarity complex component*ENSMUSG0000000387211
Lin7a / Q8JZS0 / lin-7 homolog A (C. elegans) / O14910* / lin-7 homolog A, crumbs cell polarity complex component*ENSMUSG0000001990611
C / Lin7c / O88952 / Q9NUP9* / lin-7 homolog C, crumbs cell polarity complex component*ENSMUSG0000002716210


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015482  Syntrophin
 IPR028552  Alpha-1-syntrophin
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate ISO
 biological_processGO:0003117 regulation of vasoconstriction by circulating norepinephrine IMP
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization ISO
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0086005 ventricular cardiac muscle cell action potential ISO
 biological_processGO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation ISO
 biological_processGO:1902305 regulation of sodium ion transmembrane transport ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0017080 sodium channel regulator activity ISO
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0050998 nitric-oxide synthase binding ISO
 molecular_functionGO:0051117 ATPase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Snta1tm1Scf/Snta1tm1Scf,Sntb2tm1Maad/Sntb2tm1Maad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln,Flt4tm1Ali/Flt4+
Genetic Background: involves: C57BL/6

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snta1tm1Scf/Snta1tm1Scf,Sntb2tm1Maad/Sntb2tm1Maad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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