ENSMUSG00000019861


Mus musculus

Features
Gene ID: ENSMUSG00000019861
  
Biological name :Gopc
  
Synonyms : golgi associated PDZ and coiled-coil motif containing / Gopc / Q8BH60
  
Possible biological names infered from orthology : AL132671.2
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B3
Gene start: 52335850
Gene end: 52382124
  
Corresponding Affymetrix probe sets: 10369086 (MoGene1.0st)   1421191_s_at (Mouse Genome 430 2.0 Array)   1450153_at (Mouse Genome 430 2.0 Array)   1453221_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151773
Ensembl peptide - ENSMUSP00000020008
Ensembl peptide - ENSMUSP00000101115
Ensembl peptide - ENSMUSP00000151595
NCBI entrez gene - 94221     See in Manteia.
MGI - MGI:2149946
RefSeq - NM_001199272
RefSeq - NM_053187
RefSeq Peptide - NP_001186201
RefSeq Peptide - NP_444417
swissprot - Q8BH60
swissprot - A0A1W2P7A5
swissprot - A0A1W2P7V0
swissprot - K3W4Q9
Ensembl - ENSMUSG00000019861
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gopcENSDARG00000023117Danio rerio
 ENSGALG00000014902Gallus gallus
 AL132671.2ENSG00000282218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sntb2 / Q61235 / syntrophin, basic 2 / Q13425* / syntrophin beta 2*ENSMUSG0000004130817
Sntb1 / Q99L88 / Beta-1-syntrophin / Q13884* / syntrophin beta 1*ENSMUSG0000006042916
Snta1 / Q61234 / Alpha-1-syntrophin / Q13424* / syntrophin alpha 1*ENSMUSG0000002748815
Sntg2 / Q925E0 / Gamma-2-syntrophin / Q9NY99* / syntrophin gamma 2*ENSMUSG0000002067215
Sntg1 / gamma-1-syntrophin isoform 3 / Q9NSN8* / syntrophin gamma 1*ENSMUSG0000002590913
Lin7a / Q8JZS0 / lin-7 homolog A (C. elegans) / O14910* / lin-7 homolog A, crumbs cell polarity complex component*ENSMUSG0000001990613
B / Lin7b / O88951 / Q9HAP6* / lin-7 homolog B, crumbs cell polarity complex component*ENSMUSG0000000387213
C / Lin7c / O88952 / Q9NUP9* / lin-7 homolog C, crumbs cell polarity complex component*ENSMUSG0000002716213


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy TAS
 biological_processGO:0007289 spermatid nucleus differentiation IMP
 biological_processGO:0010360 negative regulation of anion channel activity ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0043004 cytoplasmic sequestering of CFTR protein ISO
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:2000009 negative regulation of protein localization to cell surface ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle ISS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0019905 syntaxin binding ISS
 molecular_functionGO:0030695 GTPase regulator activity IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0044325 ion channel binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gopctm1.1Tno/Gopctm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gopctm1.1Tno/Gopctm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

Allelic Composition: Gopctm1.1Tno/Gopctm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008839 absent acrosome "mature spermatozoa lack the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gopctm1.1Tno/Gopctm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Gopctm1.1Tno/Gopctm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gopctm1.1Tno/Gopctm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gopctm1.1Tno/Gopctm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

Allelic Composition: Gopctm1.1Tno/Gopctm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Gopctm1.1Tno/Gopctm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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