ENSMUSG00000027162


Mus musculus

Features
Gene ID: ENSMUSG00000027162
  
Biological name :Lin7c
  
Synonyms : C / Lin7c / O88952
  
Possible biological names infered from orthology : lin-7 homolog C, crumbs cell polarity complex component / Q9NUP9
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E3
Gene start: 109890853
Gene end: 109901003
  
Corresponding Affymetrix probe sets: 10474411 (MoGene1.0st)   1418898_at (Mouse Genome 430 2.0 Array)   1423322_at (Mouse Genome 430 2.0 Array)   1449262_s_at (Mouse Genome 430 2.0 Array)   1450937_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028583
NCBI entrez gene - 22343     See in Manteia.
MGI - MGI:1330839
RefSeq - NM_011699
RefSeq Peptide - NP_035829
swissprot - O88952
Ensembl - ENSMUSG00000027162
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LIN7CENSGALG00000012170Gallus gallus
 LIN7CENSG00000148943Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B / Lin7b / O88951 / Q9HAP6* / lin-7 homolog B, crumbs cell polarity complex component*ENSMUSG0000000387285
Lin7a / Q8JZS0 / lin-7 homolog A (C. elegans) / O14910* / lin-7 homolog A, crumbs cell polarity complex component*ENSMUSG0000001990680
Gopc / Q8BH60 / golgi associated PDZ and coiled-coil motif containing / AL132671.2*ENSMUSG0000001986129
Sntb1 / Q99L88 / Beta-1-syntrophin / Q13884* / syntrophin beta 1*ENSMUSG0000006042927
Sntb2 / Q61235 / syntrophin, basic 2 / Q13425* / syntrophin beta 2*ENSMUSG0000004130826
Sntg2 / Q925E0 / Gamma-2-syntrophin / Q9NY99* / syntrophin gamma 2*ENSMUSG0000002067225
Snta1 / Q61234 / Alpha-1-syntrophin / Q13424* / syntrophin alpha 1*ENSMUSG0000002748825
Sntg1 / gamma-1-syntrophin isoform 3 / Q9NSN8* / syntrophin gamma 1*ENSMUSG0000002590920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR014775  L27 domain, C-terminal
 IPR017365  Protein lin-7
 IPR036034  PDZ superfamily
 IPR036892  L27 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002011 morphogenesis of an epithelial sheet IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007269 neurotransmitter secretion IGI
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0045199 maintenance of epithelial cell apical/basal polarity IBA
 biological_processGO:1903361 protein localization to basolateral plasma membrane IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0097025 MPP7-DLG1-LIN7 complex IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0097016 L27 domain binding IEA


Pathways (from Reactome)
Pathway description
Dopamine Neurotransmitter Release Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003604 single kidney 
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005558 decreased creatinine clearance "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Afdntm1Ytk/Afdntm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024897 Apba1 / B2RUJ5 / Amyloid-beta A4 protein-binding family A member 1 / Q02410* / amyloid beta precursor protein binding family A member 1*  / complex / reaction
 ENSMUSG00000031012 Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*  / complex / reaction






 

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