ENSMUSG00000026527


Mus musculus

Features
Gene ID: ENSMUSG00000026527
  
Biological name :Rgs7
  
Synonyms : O54829 / regulator of G protein signaling 7 / Rgs7
  
Possible biological names infered from orthology : P49802
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 175059087
Gene end: 175492500
  
Corresponding Affymetrix probe sets: 10360418 (MoGene1.0st)   1450659_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142181
Ensembl peptide - ENSMUSP00000142180
Ensembl peptide - ENSMUSP00000142278
Ensembl peptide - ENSMUSP00000027812
Ensembl peptide - ENSMUSP00000141284
Ensembl peptide - ENSMUSP00000141380
Ensembl peptide - ENSMUSP00000141855
NCBI entrez gene - 24012     See in Manteia.
MGI - MGI:1346089
RefSeq - XM_017320468
RefSeq - XM_006496829
RefSeq - XM_006496830
RefSeq - XM_006496831
RefSeq - XM_006496833
RefSeq - XM_006496834
RefSeq - XM_011238808
RefSeq - XM_011238809
RefSeq - XM_017320465
RefSeq - XM_017320467
RefSeq - NM_001199003
RefSeq - NM_011880
RefSeq - XM_006496828
RefSeq Peptide - NP_001185932
RefSeq Peptide - NP_001334124
RefSeq Peptide - NP_036010
swissprot - O54829
swissprot - Q45FE1
swissprot - A0A0A6YW36
swissprot - Q45FE2
swissprot - Q80XD3
swissprot - A0A0A6YVV6
Ensembl - ENSMUSG00000026527
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs7aENSDARG00000016584Danio rerio
 rgs7bENSDARG00000096687Danio rerio
 RGS7ENSGALG00000039772Gallus gallus
 RGS7ENSG00000182901Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs6 / Q9Z2H2 / regulator of G-protein signaling 6 / P49758*ENSMUSG0000002121972
Rgs9 / O54828 / Regulator of G-protein signaling 9 / O75916*ENSMUSG0000002059936
Rgs11 / regulator of G-protein signaling 11 / O94810*ENSMUSG0000002418636
Rgs12 / Q8CGE9 / regulator of G-protein signaling 12 / O14924*ENSMUSG0000002910123
Rgs14 / P97492 / Regulator of G-protein signaling 14 / O43566*ENSMUSG0000005208712
Rgs10 / Q9CQE5 / regulator of G-protein signalling 10 / O43665* / regulator of G protein signaling 10*ENSMUSG0000003084410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR015898  G-protein gamma-like domain
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR036284  G-protein gamma-like domain superfamily
 IPR036305  RGS domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IGI
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0044292 dendrite terminus IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031681 G-protein beta-subunit binding ISO


Pathways (from Reactome)
Pathway description
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Chuktm1Mka/Chuk+,Irf6tm1Mjd/Irf6tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Chuktm1Mka/Chuk+,Irf6tm1Mjd/Irf6tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: C57BL/6

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Lex/Rgs7tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1.1Kama/Rgs7tm1.1Kama
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * FVB/N * SJL

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rgs11tm1Lex/Rgs11tm1Lex,Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Ednrbs/Ednrbs-4Chlc
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rgs7tm1Cjch/Rgs7tm1Cjch
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032192 Gnb5 / P62881 / guanine nucleotide binding protein (G protein), beta 5 / O14775* / G protein subunit beta 5*  / complex / reaction






 

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