ENSMUSG00000021219


Mus musculus

Features
Gene ID: ENSMUSG00000021219
  
Biological name :Rgs6
  
Synonyms : Q9Z2H2 / regulator of G-protein signaling 6 / Rgs6
  
Possible biological names infered from orthology : P49758
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D1
Gene start: 82588292
Gene end: 83162056
  
Corresponding Affymetrix probe sets: 10397030 (MoGene1.0st)   10397052 (MoGene1.0st)   1427340_at (Mouse Genome 430 2.0 Array)   1452399_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139940
Ensembl peptide - ENSMUSP00000139735
Ensembl peptide - ENSMUSP00000140188
Ensembl peptide - ENSMUSP00000144395
Ensembl peptide - ENSMUSP00000144139
Ensembl peptide - ENSMUSP00000144118
Ensembl peptide - ENSMUSP00000144044
Ensembl peptide - ENSMUSP00000143961
Ensembl peptide - ENSMUSP00000143829
Ensembl peptide - ENSMUSP00000143801
Ensembl peptide - ENSMUSP00000141079
Ensembl peptide - ENSMUSP00000141044
Ensembl peptide - ENSMUSP00000140723
Ensembl peptide - ENSMUSP00000140701
Ensembl peptide - ENSMUSP00000098793
Ensembl peptide - ENSMUSP00000125256
Ensembl peptide - ENSMUSP00000139566
Ensembl peptide - ENSMUSP00000139718
Ensembl peptide - ENSMUSP00000139725
NCBI entrez gene - 50779     See in Manteia.
MGI - MGI:1354730
RefSeq - XM_011244138
RefSeq - NM_001282061
RefSeq - NM_001310478
RefSeq - NM_015812
RefSeq - XM_006516070
RefSeq - XM_011244133
RefSeq - XM_011244134
RefSeq - XM_011244135
RefSeq - XM_011244136
RefSeq - XM_011244137
RefSeq Peptide - NP_001268990
RefSeq Peptide - NP_001297407
RefSeq Peptide - NP_056627
swissprot - A0A087WPC4
swissprot - Q3UTM5
swissprot - Q9Z2H2
swissprot - A0A087WNZ9
swissprot - A0A0J9YUY2
swissprot - A0A0J9YUE4
swissprot - A0A0J9YUD1
swissprot - A0A0J9YU74
swissprot - A0A0J9YTS6
swissprot - A0A087WSJ9
swissprot - A0A087WSH2
swissprot - A0A087WRP8
swissprot - A0A087WPW1
swissprot - A0A087WQG6
swissprot - A0A087WPD1
swissprot - F6WDS8
Ensembl - ENSMUSG00000021219
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs6ENSDARG00000015627Danio rerio
 RGS6ENSGALG00000009368Gallus gallus
 RGS6ENSG00000182732Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs7 / O54829 / regulator of G protein signaling 7 / P49802*ENSMUSG0000002652770
Rgs9 / O54828 / Regulator of G-protein signaling 9 / O75916*ENSMUSG0000002059935
Rgs11 / regulator of G-protein signaling 11 / O94810*ENSMUSG0000002418632
Rgs12 / Q8CGE9 / regulator of G-protein signaling 12 / O14924*ENSMUSG0000002910122
Rgs14 / P97492 / Regulator of G-protein signaling 14 / O43566*ENSMUSG0000005208712
Rgs10 / Q9CQE5 / regulator of G-protein signalling 10 / O43665* / regulator of G protein signaling 10*ENSMUSG000000308449


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR015898  G-protein gamma-like domain
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR036284  G-protein gamma-like domain superfamily
 IPR036305  RGS domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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