ENSMUSG00000019920


Mus musculus

Features
Gene ID: ENSMUSG00000019920
  
Biological name :Lims1
  
Synonyms : Lims1 / Mus musculus LIM and senescent cell antigen-like domains 1 (Lims1), transcript variant 6, mRNA.
  
Possible biological names infered from orthology : LIMS3 / LIMS4 / LIM zinc finger domain containing 1 / LIM zinc finger domain containing 3 / LIM zinc finger domain containing 4 / P0CW19 / P0CW20 / P48059
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 58323466
Gene end: 58424691
  
Corresponding Affymetrix probe sets: 10363265 (MoGene1.0st)   1418230_a_at (Mouse Genome 430 2.0 Array)   1418231_at (Mouse Genome 430 2.0 Array)   1418232_s_at (Mouse Genome 430 2.0 Array)   1441411_at (Mouse Genome 430 2.0 Array)   1443947_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101108
Ensembl peptide - ENSMUSP00000020077
Ensembl peptide - ENSMUSP00000020078
NCBI entrez gene - 110829     See in Manteia.
MGI - MGI:1195263
RefSeq - XM_006513073
RefSeq - NM_001359116
RefSeq - NM_026148
RefSeq - NM_201242
RefSeq - XM_006513068
RefSeq - XM_006513069
RefSeq - XM_006513070
RefSeq - XM_006513071
RefSeq - XM_006513072
RefSeq - NM_001193303
RefSeq - NM_001346676
RefSeq Peptide - NP_080424
RefSeq Peptide - NP_001180232
RefSeq Peptide - NP_001333605
RefSeq Peptide - NP_957694
RefSeq Peptide - NP_001346045
swissprot - Q9D7B2
swissprot - E9QP62
swissprot - A0A0R4J005
Ensembl - ENSMUSG00000019920
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lims1ENSDARG00000026985Danio rerio
 lims2ENSDARG00000014976Danio rerio
 LIMS1ENSGALG00000029970Gallus gallus
 LIMS1ENSG00000169756Homo sapiens
 LIMS3ENSG00000256977Homo sapiens
 LIMS4ENSG00000256671Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lims2 / Q91XD2 / LIM and senescent cell antigen-like-containing domain protein 2 / Q7Z4I7* / LIM zinc finger domain containing 2*ENSMUSG0000002439567
Pdlim5 / Q8CI51 / PDZ and LIM domain protein 5 / Q96HC4* / PDZ and LIM domain 5*ENSMUSG0000002827321
Ldb3 / Q9JKS4 / LIM domain-binding protein 3 / O75112* / LIM domain binding 3*ENSMUSG0000002179820
Pdlim7 / Q3TJD7 / PDZ and LIM domain protein 7 / Q9NR12* / PDZ and LIM domain 7*ENSMUSG0000002149319
Fhl3 / Q9R059 / Four and a half LIM domains protein 3 / Q13643* / four and a half LIM domains 3*ENSMUSG0000003264319
Fhl4ENSMUSG0000005003518
Fhl2 / O70433 / Four and a half LIM domains protein 2 / Q14192* / four and a half LIM domains 2*ENSMUSG0000000813618
Q62219 / Tgfb1i1 / Transforming growth factor beta-1-induced transcript 1 protein / O43294* / transforming growth factor beta 1 induced transcript 1*ENSMUSG0000003078217
Pxn / Q8VI36 / Paxillin / P49023*ENSMUSG0000002952817
Fhl1 / P97447 / Four and a half LIM domains protein 1 / Q13642* / four and a half LIM domains 1*ENSMUSG0000002309217
Fhl5 / Q9WTX7 / Four and a half LIM domains protein 5 / Q5TD97* / four and a half LIM domains 5*ENSMUSG0000002825917
Lpxn / Q99N69 / Leupaxin / O60711*ENSMUSG0000002469615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR017351  LIM and senescent cell antigen-like-containing domain protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0010489 abnormal heart atrium auricular region morphology "any structural anomaly of the small conical pouch projections located on the upper anterior portion of each atrium of the heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0010499 abnormal ventricle myocardium morphology "any structural anomaly of the ventricular part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Lims1tm2Ref/Lims1tm2Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

 MP:0011198 absent proamniotic cavity "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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