ENSMUSG00000028259


Mus musculus

Features
Gene ID: ENSMUSG00000028259
  
Biological name :Fhl5
  
Synonyms : Fhl5 / Four and a half LIM domains protein 5 / Q9WTX7
  
Possible biological names infered from orthology : four and a half LIM domains 5 / Q5TD97
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A3
Gene start: 25199908
Gene end: 25242876
  
Corresponding Affymetrix probe sets: 10511835 (MoGene1.0st)   1449332_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029922
Ensembl peptide - ENSMUSP00000103839
NCBI entrez gene - 57756     See in Manteia.
MGI - MGI:1913192
RefSeq - XM_011250080
RefSeq - NM_021318
RefSeq - XM_006538125
RefSeq Peptide - NP_001342427
RefSeq Peptide - NP_067293
swissprot - Q9WTX7
Ensembl - ENSMUSG00000028259
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fhl5ENSDARG00000014805Danio rerio
 FHL5ENSGALG00000015573Gallus gallus
 FHL5ENSG00000112214Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fhl2 / O70433 / Four and a half LIM domains protein 2 / Q14192* / four and a half LIM domains 2*ENSMUSG0000000813658
Fhl3 / Q9R059 / Four and a half LIM domains protein 3 / Q13643* / four and a half LIM domains 3*ENSMUSG0000003264346
Fhl4ENSMUSG0000005003544
Fhl1 / P97447 / Four and a half LIM domains protein 1 / Q13642* / four and a half LIM domains 1*ENSMUSG0000002309240
Pdlim5 / Q8CI51 / PDZ and LIM domain protein 5 / Q96HC4* / PDZ and LIM domain 5*ENSMUSG0000002827325
Ldb3 / Q9JKS4 / LIM domain-binding protein 3 / O75112* / LIM domain binding 3*ENSMUSG0000002179824
Lims2 / Q91XD2 / LIM and senescent cell antigen-like-containing domain protein 2 / Q7Z4I7* / LIM zinc finger domain containing 2*ENSMUSG0000002439524
Pxn / Q8VI36 / Paxillin / P49023*ENSMUSG0000002952823
Lims1 / Mus musculus LIM and senescent cell antigen-like domains 1 (Lims1), transcript variant 6, mRNA. / LIMS3* / LIMS4* / P48059* / P0CW19* / P0CW20* / LIM zinc finger domain containing 1...ENSMUSG0000001992023
Pdlim7 / Q3TJD7 / PDZ and LIM domain protein 7 / Q9NR12* / PDZ and LIM domain 7*ENSMUSG0000002149321
Q62219 / Tgfb1i1 / Transforming growth factor beta-1-induced transcript 1 protein / O43294* / transforming growth factor beta 1 induced transcript 1*ENSMUSG0000003078221
Lpxn / Q99N69 / Leupaxin / O60711*ENSMUSG0000002469620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0002662 abnormal cauda "anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0008975 delayed male fertility "ability of a male organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

 MP:0009243 hairpin sperm flagellum "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+
Genetic Background: involves: 129S4/SvEvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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