ENSMUSG00000024395


Mus musculus

Features
Gene ID: ENSMUSG00000024395
  
Biological name :Lims2
  
Synonyms : LIM and senescent cell antigen-like-containing domain protein 2 / Lims2 / Q91XD2
  
Possible biological names infered from orthology : LIM zinc finger domain containing 2 / Q7Z4I7
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B1
Gene start: 31931325
Gene end: 31958619
  
Corresponding Affymetrix probe sets: 10454514 (MoGene1.0st)   1424408_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025254
Ensembl peptide - ENSMUSP00000153433
Ensembl peptide - ENSMUSP00000153218
Ensembl peptide - ENSMUSP00000153122
Ensembl peptide - ENSMUSP00000152960
NCBI entrez gene - 225341     See in Manteia.
MGI - MGI:2385067
RefSeq - XM_011246899
RefSeq - NM_144862
RefSeq - XM_006525845
RefSeq - XM_006525846
RefSeq Peptide - NP_659111
swissprot - A0A286YDH9
swissprot - Q91XD2
swissprot - A0A286YCS7
swissprot - A0A286YCF2
swissprot - A0A286YD07
Ensembl - ENSMUSG00000024395
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000043966Gallus gallus
 ENSGALG00000045055Gallus gallus
 ENSGALG00000001995Gallus gallus
 LIMS2ENSG00000072163Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lims1 / Mus musculus LIM and senescent cell antigen-like domains 1 (Lims1), transcript variant 6, mRNA. / LIMS3* / LIMS4* / P48059* / P0CW19* / P0CW20* / LIM zinc finger domain containing 1...ENSMUSG0000001992078
Pdlim5 / Q8CI51 / PDZ and LIM domain protein 5 / Q96HC4* / PDZ and LIM domain 5*ENSMUSG0000002827322
Fhl1 / P97447 / Four and a half LIM domains protein 1 / Q13642* / four and a half LIM domains 1*ENSMUSG0000002309221
Fhl3 / Q9R059 / Four and a half LIM domains protein 3 / Q13643* / four and a half LIM domains 3*ENSMUSG0000003264321
Fhl4ENSMUSG0000005003521
Fhl2 / O70433 / Four and a half LIM domains protein 2 / Q14192* / four and a half LIM domains 2*ENSMUSG0000000813621
Pxn / Q8VI36 / Paxillin / P49023*ENSMUSG0000002952821
Q62219 / Tgfb1i1 / Transforming growth factor beta-1-induced transcript 1 protein / O43294* / transforming growth factor beta 1 induced transcript 1*ENSMUSG0000003078220
Ldb3 / Q9JKS4 / LIM domain-binding protein 3 / O75112* / LIM domain binding 3*ENSMUSG0000002179820
Pdlim7 / Q3TJD7 / PDZ and LIM domain protein 7 / Q9NR12* / PDZ and LIM domain 7*ENSMUSG0000002149320
Fhl5 / Q9WTX7 / Four and a half LIM domains protein 5 / Q5TD97* / four and a half LIM domains 5*ENSMUSG0000002825920
Lpxn / Q99N69 / Leupaxin / O60711*ENSMUSG0000002469617


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR017351  LIM and senescent cell antigen-like-containing domain protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0045216 cell-cell junction organization IGI
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IGI
 biological_processGO:0098609 cell-cell adhesion IGI
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IGI
 biological_processGO:2000346 negative regulation of hepatocyte proliferation IGI
 biological_processGO:2001046 positive regulation of integrin-mediated signaling pathway IGI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbl1tm1Kata/Mbl1tm1Kata,Mbl2tm1Kata/Mbl2tm1Kata
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0010489 abnormal heart atrium auricular region morphology "any structural anomaly of the small conical pouch projections located on the upper anterior portion of each atrium of the heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0010499 abnormal ventricle myocardium morphology "any structural anomaly of the ventricular part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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