ENSMUSG00000028273


Mus musculus

Features
Gene ID: ENSMUSG00000028273
  
Biological name :Pdlim5
  
Synonyms : Pdlim5 / PDZ and LIM domain protein 5 / Q8CI51
  
Possible biological names infered from orthology : PDZ and LIM domain 5 / Q96HC4
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H1
Gene start: 142239590
Gene end: 142395696
  
Corresponding Affymetrix probe sets: 10502469 (MoGene1.0st)   1421413_a_at (Mouse Genome 430 2.0 Array)   1422861_s_at (Mouse Genome 430 2.0 Array)   1422862_at (Mouse Genome 430 2.0 Array)   1422863_s_at (Mouse Genome 430 2.0 Array)   1427475_a_at (Mouse Genome 430 2.0 Array)   1429783_at (Mouse Genome 430 2.0 Array)   1450786_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132647
Ensembl peptide - ENSMUSP00000128752
Ensembl peptide - ENSMUSP00000142460
Ensembl peptide - ENSMUSP00000143762
Ensembl peptide - ENSMUSP00000143343
Ensembl peptide - ENSMUSP00000143098
Ensembl peptide - ENSMUSP00000142899
Ensembl peptide - ENSMUSP00000142790
Ensembl peptide - ENSMUSP00000142737
Ensembl peptide - ENSMUSP00000029941
Ensembl peptide - ENSMUSP00000059267
Ensembl peptide - ENSMUSP00000087595
NCBI entrez gene - 56376     See in Manteia.
MGI - MGI:1927489
RefSeq - XM_017319659
RefSeq - NM_001190853
RefSeq - NM_001190854
RefSeq - NM_001190855
RefSeq - NM_001190856
RefSeq - NM_001190857
RefSeq - NM_019808
RefSeq - NM_019809
RefSeq - NM_022554
RefSeq - XM_006501738
RefSeq - XM_006501739
RefSeq - XM_006501740
RefSeq - XM_006501741
RefSeq - XM_006501742
RefSeq - XM_006501743
RefSeq - XM_006501744
RefSeq - XM_006501745
RefSeq - XM_006501746
RefSeq - XM_006501748
RefSeq - XM_006501750
RefSeq - XM_006501751
RefSeq - NM_001190852
RefSeq Peptide - NP_001177783
RefSeq Peptide - NP_001177784
RefSeq Peptide - NP_001177785
RefSeq Peptide - NP_001177786
RefSeq Peptide - NP_062782
RefSeq Peptide - NP_062783
RefSeq Peptide - NP_072048
RefSeq Peptide - NP_001177781
RefSeq Peptide - NP_001177782
swissprot - E9Q8P5
swissprot - Q8CI51
swissprot - Q9CRA2
swissprot - D9J303
swissprot - D9J302
swissprot - D9J301
swissprot - D9J300
swissprot - D9J2Z9
swissprot - F8WJI6
swissprot - A0A0G2JGZ5
swissprot - A0A0G2JEJ0
Ensembl - ENSMUSG00000028273
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdlim5aENSDARG00000101777Danio rerio
 pdlim5bENSDARG00000027600Danio rerio
 PDLIM5ENSGALG00000012211Gallus gallus
 PDLIM5ENSG00000163110Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ldb3 / Q9JKS4 / LIM domain-binding protein 3 / O75112* / LIM domain binding 3*ENSMUSG0000002179839
Pdlim7 / Q3TJD7 / PDZ and LIM domain protein 7 / Q9NR12* / PDZ and LIM domain 7*ENSMUSG0000002149335
Pxn / Q8VI36 / Paxillin / P49023*ENSMUSG0000002952816
Q62219 / Tgfb1i1 / Transforming growth factor beta-1-induced transcript 1 protein / O43294* / transforming growth factor beta 1 induced transcript 1*ENSMUSG0000003078216
Lims1 / Mus musculus LIM and senescent cell antigen-like domains 1 (Lims1), transcript variant 6, mRNA. / LIMS3* / LIMS4* / P48059* / P0CW19* / P0CW20* / LIM zinc finger domain containing 1...ENSMUSG0000001992014
Lpxn / Q99N69 / Leupaxin / O60711*ENSMUSG0000002469613
Lims2 / Q91XD2 / LIM and senescent cell antigen-like-containing domain protein 2 / Q7Z4I7* / LIM zinc finger domain containing 2*ENSMUSG0000002439512
Fhl5 / Q9WTX7 / Four and a half LIM domains protein 5 / Q5TD97* / four and a half LIM domains 5*ENSMUSG0000002825912
Fhl3 / Q9R059 / Four and a half LIM domains protein 3 / Q13643* / four and a half LIM domains 3*ENSMUSG0000003264312
Fhl2 / O70433 / Four and a half LIM domains protein 2 / Q14192* / four and a half LIM domains 2*ENSMUSG0000000813611
Fhl4ENSMUSG0000005003510
Fhl1 / P97447 / Four and a half LIM domains protein 1 / Q13642* / four and a half LIM domains 1*ENSMUSG000000230929


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR031847  Domain of unknown function DUF4749
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051963 regulation of synapse assembly ISS
 biological_processGO:0061001 regulation of dendritic spine morphogenesis ISS
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction ISO
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agap2tm1.1Kye/Agap2tm1.1Kye
Genetic Background: Not Specified

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agap2tm1.1Kye/Agap2tm1.1Kye
Genetic Background: Not Specified

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agap2tm1.1Kye/Agap2tm1.1Kye
Genetic Background: Not Specified

Allelic Composition: Pdlim5tm1.1Chen/Pdlim5tm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agap2tm1.1Kye/Agap2tm1.1Kye
Genetic Background: Not Specified

Allelic Composition: Pdlim5tm1.1Chen/Pdlim5tm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pdlim5tm1.1Chen/Pdlim5tm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdlim5tm1.1Chen/Pdlim5tm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pdlim5tm1.1Chen/Pdlim5tm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdlim5tm1.1Chen/Pdlim5tm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Agap2tm1.1Kye/Agap2tm1.1Kye
Genetic Background: Not Specified

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdlim5tm1.1Chen/Pdlim5tm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0010695 abnormal blood pressure regulation "any anomaly in the process that modulates the force with which blood travels through the circulatory system, which is controlled by a balance of processes that increase pressure and decrease pressure" [GO:0008217]
Show

Allelic Composition: Pdlim5tm1.1Chen/Pdlim5tm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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