ENSMUSG00000021493


Mus musculus

Features
Gene ID: ENSMUSG00000021493
  
Biological name :Pdlim7
  
Synonyms : Pdlim7 / PDZ and LIM domain protein 7 / Q3TJD7
  
Possible biological names infered from orthology : PDZ and LIM domain 7 / Q9NR12
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 55495795
Gene end: 55513676
  
Corresponding Affymetrix probe sets: 10409486 (MoGene1.0st)   1417959_at (Mouse Genome 430 2.0 Array)   1428319_at (Mouse Genome 430 2.0 Array)   1443785_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119753
Ensembl peptide - ENSMUSP00000118867
Ensembl peptide - ENSMUSP00000120465
Ensembl peptide - ENSMUSP00000121614
Ensembl peptide - ENSMUSP00000047173
Ensembl peptide - ENSMUSP00000064219
Ensembl peptide - ENSMUSP00000070153
NCBI entrez gene - 67399     See in Manteia.
MGI - MGI:1914649
RefSeq - XM_011244559
RefSeq - NM_001114087
RefSeq - NM_001114088
RefSeq - NM_026131
RefSeq - XM_006517344
RefSeq - XM_006517345
RefSeq - XM_006517346
RefSeq - XM_006517349
RefSeq - XM_011244558
RefSeq Peptide - NP_001107559
RefSeq Peptide - NP_001107560
RefSeq Peptide - NP_080407
swissprot - Q8BVJ7
swissprot - B8JJB3
swissprot - B8JJB1
swissprot - B8JJB2
swissprot - Q3TJD7
Ensembl - ENSMUSG00000021493
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01078593.1ENSDARG00000103854Danio rerio
 PDLIM7ENSGALG00000026159Gallus gallus
 PDLIM7ENSG00000196923Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ldb3 / Q9JKS4 / LIM domain-binding protein 3 / O75112* / LIM domain binding 3*ENSMUSG0000002179847
Pdlim5 / Q8CI51 / PDZ and LIM domain protein 5 / Q96HC4* / PDZ and LIM domain 5*ENSMUSG0000002827347
Pxn / Q8VI36 / Paxillin / P49023*ENSMUSG0000002952824
Q62219 / Tgfb1i1 / Transforming growth factor beta-1-induced transcript 1 protein / O43294* / transforming growth factor beta 1 induced transcript 1*ENSMUSG0000003078223
Lims1 / Mus musculus LIM and senescent cell antigen-like domains 1 (Lims1), transcript variant 6, mRNA. / LIMS3* / LIMS4* / P48059* / P0CW19* / P0CW20* / LIM zinc finger domain containing 1...ENSMUSG0000001992017
Lpxn / Q99N69 / Leupaxin / O60711*ENSMUSG0000002469616
Lims2 / Q91XD2 / LIM and senescent cell antigen-like-containing domain protein 2 / Q7Z4I7* / LIM zinc finger domain containing 2*ENSMUSG0000002439515
Fhl2 / O70433 / Four and a half LIM domains protein 2 / Q14192* / four and a half LIM domains 2*ENSMUSG0000000813614
Fhl3 / Q9R059 / Four and a half LIM domains protein 3 / Q13643* / four and a half LIM domains 3*ENSMUSG0000003264314
Fhl5 / Q9WTX7 / Four and a half LIM domains protein 5 / Q5TD97* / four and a half LIM domains 5*ENSMUSG0000002825913
Fhl4ENSMUSG0000005003513
Fhl1 / P97447 / Four and a half LIM domains protein 1 / Q13642* / four and a half LIM domains 1*ENSMUSG0000002309212


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030036 actin cytoskeleton organization IPI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005913 cell-cell adherens junction ISO
 cellular_componentGO:0005925 focal adhesion ISO
 cellular_componentGO:0015629 actin cytoskeleton ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm11.1(Setd5-GFP)Mgn/Gt(ROSA)26Sortm11.1(Setd5-GFP)Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0010613 abnormal mitral valve anulus morphology "any structural anomaly of the fibrous ring of the mitral valve that attaches the cusps of mitral valve to the heart, and which consists of portions of the fibrous scallops of the anterior and posterior cusps" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0010621 abnormal tricuspid valve anulus morphology "any structural anomaly of the fibrous ring of the tricuspid valve that attaches the cusps of tricuspid valve to the heart, and which consists of portions of the fibrous scallops of the anterior cusp (infundibular cusp), the posterior cusp (marginal cusp), and the septal cusp (medial cusp)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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