ENSMUSG00000023092


Mus musculus

Features
Gene ID: ENSMUSG00000023092
  
Biological name :Fhl1
  
Synonyms : Fhl1 / Four and a half LIM domains protein 1 / P97447
  
Possible biological names infered from orthology : four and a half LIM domains 1 / Q13642
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A6
Gene start: 56731787
Gene end: 56793346
  
Corresponding Affymetrix probe sets: 10599736 (MoGene1.0st)   1417872_at (Mouse Genome 430 2.0 Array)   1459003_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110417
Ensembl peptide - ENSMUSP00000110416
Ensembl peptide - ENSMUSP00000110420
Ensembl peptide - ENSMUSP00000119828
Ensembl peptide - ENSMUSP00000116725
Ensembl peptide - ENSMUSP00000115700
Ensembl peptide - ENSMUSP00000112295
Ensembl peptide - ENSMUSP00000110421
Ensembl peptide - ENSMUSP00000023854
NCBI entrez gene - 14199     See in Manteia.
MGI - MGI:1298387
RefSeq - XM_017318382
RefSeq - NM_001287800
RefSeq - NM_010211
RefSeq - XM_006527800
RefSeq - XM_006527801
RefSeq - XM_006527802
RefSeq - XM_006527803
RefSeq - XM_006527804
RefSeq - XM_006527805
RefSeq - XM_006527807
RefSeq - XM_006527808
RefSeq - XM_006527809
RefSeq - XM_017318381
RefSeq - NM_001077361
RefSeq - NM_001077362
RefSeq Peptide - NP_001070830
RefSeq Peptide - NP_001274729
RefSeq Peptide - NP_034341
RefSeq Peptide - NP_001070829
swissprot - A2AEX8
swissprot - A2AEX7
swissprot - A2AEX6
swissprot - A2AEY2
swissprot - P97447
swissprot - A2AEY1
swissprot - A2AEY0
swissprot - A2AEX9
Ensembl - ENSMUSG00000023092
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fhl1aENSDARG00000071498Danio rerio
 fhl1bENSDARG00000056653Danio rerio
 FHL1ENSGALG00000006190Gallus gallus
 FHL1ENSG00000022267Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fhl4ENSMUSG0000005003551
Fhl2 / O70433 / Four and a half LIM domains protein 2 / Q14192* / four and a half LIM domains 2*ENSMUSG0000000813637
Fhl5 / Q9WTX7 / Four and a half LIM domains protein 5 / Q5TD97* / four and a half LIM domains 5*ENSMUSG0000002825936
Fhl3 / Q9R059 / Four and a half LIM domains protein 3 / Q13643* / four and a half LIM domains 3*ENSMUSG0000003264334
Lims2 / Q91XD2 / LIM and senescent cell antigen-like-containing domain protein 2 / Q7Z4I7* / LIM zinc finger domain containing 2*ENSMUSG0000002439522
Lims1 / Mus musculus LIM and senescent cell antigen-like domains 1 (Lims1), transcript variant 6, mRNA. / LIMS3* / LIMS4* / P48059* / P0CW19* / P0CW20* / LIM zinc finger domain containing 1...ENSMUSG0000001992021
Ldb3 / Q9JKS4 / LIM domain-binding protein 3 / O75112* / LIM domain binding 3*ENSMUSG0000002179818
Pdlim5 / Q8CI51 / PDZ and LIM domain protein 5 / Q96HC4* / PDZ and LIM domain 5*ENSMUSG0000002827318
Pxn / Q8VI36 / Paxillin / P49023*ENSMUSG0000002952817
Q62219 / Tgfb1i1 / Transforming growth factor beta-1-induced transcript 1 protein / O43294* / transforming growth factor beta 1 induced transcript 1*ENSMUSG0000003078217
Pdlim7 / Q3TJD7 / PDZ and LIM domain protein 7 / Q9NR12* / PDZ and LIM domain 7*ENSMUSG0000002149316
Lpxn / Q99N69 / Leupaxin / O60711*ENSMUSG0000002469615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003254 regulation of membrane depolarization ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0043268 positive regulation of potassium ion transport ISO
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity ISO
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm,Tg(Myh6-tTA)6Smbf/0,Tg(tetO-cre)3Jig/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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