ENSMUSG00000021798


Mus musculus

Features
Gene ID: ENSMUSG00000021798
  
Biological name :Ldb3
  
Synonyms : Ldb3 / LIM domain-binding protein 3 / Q9JKS4
  
Possible biological names infered from orthology : LIM domain binding 3 / O75112
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 34526603
Gene end: 34588682
  
Corresponding Affymetrix probe sets: 10418950 (MoGene1.0st)   1416752_at (Mouse Genome 430 2.0 Array)   1433783_at (Mouse Genome 430 2.0 Array)   1451999_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154758
Ensembl peptide - ENSMUSP00000087494
Ensembl peptide - ENSMUSP00000154119
Ensembl peptide - ENSMUSP00000022327
Ensembl peptide - ENSMUSP00000022328
Ensembl peptide - ENSMUSP00000022330
Ensembl peptide - ENSMUSP00000066784
NCBI entrez gene - 24131     See in Manteia.
MGI - MGI:1344412
RefSeq - XM_017316019
RefSeq - NM_001039071
RefSeq - NM_001039072
RefSeq - NM_001039073
RefSeq - NM_001039074
RefSeq - NM_001039075
RefSeq - NM_001039076
RefSeq - NM_011918
RefSeq - XM_006519017
RefSeq - XM_006519018
RefSeq - XM_006519019
RefSeq Peptide - NP_001034163
RefSeq Peptide - NP_001034164
RefSeq Peptide - NP_001034165
RefSeq Peptide - NP_036048
RefSeq Peptide - NP_001034161
RefSeq Peptide - NP_001034162
RefSeq Peptide - NP_001034160
swissprot - Q9JKS4
swissprot - E9PYJ9
Ensembl - ENSMUSG00000021798
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ldb3aENSDARG00000056322Danio rerio
 LDB3ENSG00000122367Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdlim5 / Q8CI51 / PDZ and LIM domain protein 5 / Q96HC4* / PDZ and LIM domain 5*ENSMUSG0000002827333
Pdlim7 / Q3TJD7 / PDZ and LIM domain protein 7 / Q9NR12* / PDZ and LIM domain 7*ENSMUSG0000002149329
Q62219 / Tgfb1i1 / Transforming growth factor beta-1-induced transcript 1 protein / O43294* / transforming growth factor beta 1 induced transcript 1*ENSMUSG0000003078215
Pxn / Q8VI36 / Paxillin / P49023*ENSMUSG0000002952815
Lims1 / Mus musculus LIM and senescent cell antigen-like domains 1 (Lims1), transcript variant 6, mRNA. / LIMS3* / LIMS4* / P48059* / P0CW19* / P0CW20* / LIM zinc finger domain containing 1...ENSMUSG0000001992011
Lpxn / Q99N69 / Leupaxin / O60711*ENSMUSG0000002469611
Fhl5 / Q9WTX7 / Four and a half LIM domains protein 5 / Q5TD97* / four and a half LIM domains 5*ENSMUSG0000002825910
Fhl3 / Q9R059 / Four and a half LIM domains protein 3 / Q13643* / four and a half LIM domains 3*ENSMUSG0000003264310
Fhl2 / O70433 / Four and a half LIM domains protein 2 / Q14192* / four and a half LIM domains 2*ENSMUSG0000000813610
Lims2 / Q91XD2 / LIM and senescent cell antigen-like-containing domain protein 2 / Q7Z4I7* / LIM zinc finger domain containing 2*ENSMUSG0000002439510
Fhl4ENSMUSG0000005003510
Fhl1 / P97447 / Four and a half LIM domains protein 1 / Q13642* / four and a half LIM domains 1*ENSMUSG000000230928


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR006643  Zasp-like motif
 IPR031847  Domain of unknown function DUF4749
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045214 sarcomere organization IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005080 protein kinase C binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051371 muscle alpha-actinin binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ldb3tm2Chen/Ldb3tm2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ldb3tm2Chen/Ldb3tm2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nkx2-1tm1Shk/Nkx2-1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm2Chen/Ldb3tm2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0003158 dysphagia "difficulty in swallowing food or liquid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldb3tm2Chen/Ldb3tm2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldb3tm2Chen/Ldb3tm2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0010021 heart vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

 MP:0010563 increased heart right ventricle size "greater than average size of the right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ldb3tm2Chen/Ldb3tm2Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Ldb3tm6.2Chen/Ldb3tm6.2Chen
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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