ENSMUSG00000030782


Mus musculus

Features
Gene ID: ENSMUSG00000030782
  
Biological name :Tgfb1i1
  
Synonyms : Q62219 / Tgfb1i1 / Transforming growth factor beta-1-induced transcript 1 protein
  
Possible biological names infered from orthology : O43294 / transforming growth factor beta 1 induced transcript 1
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 128246812
Gene end: 128255699
  
Corresponding Affymetrix probe sets: 10557960 (MoGene1.0st)   1418136_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132100
Ensembl peptide - ENSMUSP00000131705
Ensembl peptide - ENSMUSP00000132685
Ensembl peptide - ENSMUSP00000133134
Ensembl peptide - ENSMUSP00000068529
Ensembl peptide - ENSMUSP00000127695
Ensembl peptide - ENSMUSP00000129958
Ensembl peptide - ENSMUSP00000130964
NCBI entrez gene - 21804     See in Manteia.
MGI - MGI:102784
RefSeq - XM_011241729
RefSeq - NM_001289550
RefSeq - NM_001289551
RefSeq - NM_001289552
RefSeq - NM_001289553
RefSeq - XM_006507567
RefSeq - XM_011241725
RefSeq - XM_011241727
RefSeq - XM_011241728
RefSeq Peptide - NP_001276481
RefSeq Peptide - NP_001276482
RefSeq Peptide - NP_001276479
RefSeq Peptide - NP_001276480
swissprot - Q62219
swissprot - E9Q1D5
swissprot - E9Q1V4
swissprot - E9PYQ1
Ensembl - ENSMUSG00000030782
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O43294ENSG00000140682Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pxn / Q8VI36 / Paxillin / P49023*ENSMUSG0000002952851
Lpxn / Q99N69 / Leupaxin / O60711*ENSMUSG0000002469639
Pdlim7 / Q3TJD7 / PDZ and LIM domain protein 7 / Q9NR12* / PDZ and LIM domain 7*ENSMUSG0000002149323
Ldb3 / Q9JKS4 / LIM domain-binding protein 3 / O75112* / LIM domain binding 3*ENSMUSG0000002179823
Pdlim5 / Q8CI51 / PDZ and LIM domain protein 5 / Q96HC4* / PDZ and LIM domain 5*ENSMUSG0000002827321
Fhl3 / Q9R059 / Four and a half LIM domains protein 3 / Q13643* / four and a half LIM domains 3*ENSMUSG0000003264315
Fhl2 / O70433 / Four and a half LIM domains protein 2 / Q14192* / four and a half LIM domains 2*ENSMUSG0000000813615
Lims1 / Mus musculus LIM and senescent cell antigen-like domains 1 (Lims1), transcript variant 6, mRNA. / LIMS3* / LIMS4* / P48059* / P0CW19* / P0CW20* / LIM zinc finger domain containing 1...ENSMUSG0000001992015
Lims2 / Q91XD2 / LIM and senescent cell antigen-like-containing domain protein 2 / Q7Z4I7* / LIM zinc finger domain containing 2*ENSMUSG0000002439515
Fhl5 / Q9WTX7 / Four and a half LIM domains protein 5 / Q5TD97* / four and a half LIM domains 5*ENSMUSG0000002825913
Fhl4ENSMUSG0000005003512
Fhl1 / P97447 / Four and a half LIM domains protein 1 / Q13642* / four and a half LIM domains 1*ENSMUSG0000002309212


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR017305  Leupaxin/Paxillin/TGFB1I1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016331 morphogenesis of embryonic epithelium IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0030579 ubiquitin-dependent SMAD protein catabolic process ISO
 biological_processGO:0030855 epithelial cell differentiation IGI
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0045599 negative regulation of fat cell differentiation IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048495 Roundabout binding ISO
 molecular_functionGO:0050681 androgen receptor binding ISO
 molecular_functionGO:0070411 I-SMAD binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Tfebtm1b(EUCOMM)Wtsi/Tfebtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tfebtm1b(EUCOMM)Wtsi/Bay

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfebtm1b(EUCOMM)Wtsi/Tfebtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tfebtm1b(EUCOMM)Wtsi/Bay

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tfebtm1b(EUCOMM)Wtsi/Tfebtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tfebtm1b(EUCOMM)Wtsi/Bay

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tfebtm1b(EUCOMM)Wtsi/Tfebtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tfebtm1b(EUCOMM)Wtsi/Bay

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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