ENSMUSG00000116121


Mus musculus

Features
Gene ID: ENSMUSG00000116121
  
Biological name :Pick1
  
Synonyms : Pick1
  
Possible biological names infered from orthology : protein interacting with PRKCA 1 / Q9NRD5
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 79229391
Gene end: 79256674
  
Corresponding Affymetrix probe sets: 10425267 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000061125
MGI - MGI:6155161
MGI - MGI:894645
swissprot - E9QAC6
Ensembl - ENSMUSG00000116121
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pick1ENSDARG00000071152Danio rerio
 PICK1ENSGALG00000041823Gallus gallus
 PICK1ENSG00000100151Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pick1 / protein interacting with C kinase 1 / Q9NRD5* / protein interacting with PRKCA 1*ENSMUSG0000006820665


Protein motifs (from Interpro)
Interpro ID Name
 IPR001079  Galectin, carbohydrate recognition domain
 IPR001478  PDZ domain
 IPR010504  Arfaptin homology (AH) domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR027267  AH/BAR domain superfamily
 IPR030798  Arfaptin family
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
Trafficking of GluR2-containing AMPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria2tm1Rlh/Gria2tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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