ENSMUSG00000022877


Mus musculus

Features
Gene ID: ENSMUSG00000022877
  
Biological name :Hrg
  
Synonyms : histidine rich glycoprotein / Hrg
  
Possible biological names infered from orthology : P04196
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B1
Gene start: 22951072
Gene end: 22961656
  
Corresponding Affymetrix probe sets: 10434709 (MoGene1.0st)   1449242_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023590
NCBI entrez gene - 94175     See in Manteia.
MGI - MGI:2146636
RefSeq - NM_053176
RefSeq Peptide - NP_444406
swissprot - A0A0R4J039
Ensembl - ENSMUSG00000022877
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000008646Gallus gallus
 HRGENSG00000113905Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002839 positive regulation of immune response to tumor cell IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010593 negative regulation of lamellipodium assembly IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030193 regulation of blood coagulation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0033629 negative regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043254 regulation of protein complex assembly IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050832 defense response to fungus IEA
 biological_processGO:0051715 cytolysis in other organism IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IEA
 biological_processGO:1900747 negative regulation of vascular endothelial growth factor signaling pathway IEA
 biological_processGO:2000504 positive regulation of blood vessel remodeling IEA
 biological_processGO:2001027 negative regulation of endothelial cell chemotaxis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019865 immunoglobulin binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

 MP:0003422 abnormal thrombolysis "altered ability to break up (lyse) blood clots that are restricting the blood flow" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:17427]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

 MP:0010213 abnormal circulating fibrinogen level "deviation from the normal levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021822 Plau / P06869 / plasminogen activator, urokinase / P00749*  / reaction
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / complex / reaction






 

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