ENSG00000113905


Homo sapiens

Features
Gene ID: ENSG00000113905
  
Biological name :HRG
  
Synonyms : histidine rich glycoprotein / HRG / P04196
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q27.3
Gene start: 186660216
Gene end: 186678240
  
Corresponding Affymetrix probe sets: 206226_at (Human Genome U133 Plus 2.0 Array)   31835_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000232003
NCBI entrez gene - 3273     See in Manteia.
OMIM - 142640
RefSeq - NM_000412
RefSeq - XM_005247415
RefSeq Peptide - NP_000403
swissprot - P04196
Ensembl - ENSG00000113905
  
Related genetic diseases (OMIM): 613116 - Thrombophilia due to HRG deficiency, 613116
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000008646Gallus gallus
 HrgENSMUSG00000022877Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0002839 positive regulation of immune response to tumor cell IDA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010543 regulation of platelet activation IBA
 biological_processGO:0010593 negative regulation of lamellipodium assembly IDA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0015886 heme transport IBA
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0030168 platelet activation IDA
 biological_processGO:0030193 regulation of blood coagulation IDA
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IDA
 biological_processGO:0033629 negative regulation of cell adhesion mediated by integrin IDA
 biological_processGO:0042730 fibrinolysis TAS
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043254 regulation of protein complex assembly IDA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration ISS
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050832 defense response to fungus IDA
 biological_processGO:0051715 cytolysis in other organism IDA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IDA
 biological_processGO:0051918 negative regulation of fibrinolysis IBA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 biological_processGO:1900747 negative regulation of vascular endothelial growth factor signaling pathway IDA
 biological_processGO:2000504 positive regulation of blood vessel remodeling IDA
 biological_processGO:2001027 negative regulation of endothelial cell chemotaxis IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0036019 endolysosome IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0019865 immunoglobulin binding IDA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0004831 recurrent thromboembolic disease 
Show

 HP:0100724 Hypercoagulability 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122194 PLG / P00747 / plasminogen  / complex / reaction
 ENSG00000122861 PLAU / P00749 / plasminogen activator, urokinase  / reaction






 

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