ENSMUSG00000028019


Mus musculus

Features
Gene ID: ENSMUSG00000028019
  
Biological name :Pdgfc
  
Synonyms : Pdgfc / platelet-derived growth factor, C polypeptide / Q8CI19
  
Possible biological names infered from orthology : platelet derived growth factor C / Q9NRA1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E3
Gene start: 81036416
Gene end: 81214040
  
Corresponding Affymetrix probe sets: 10492689 (MoGene1.0st)   1419123_a_at (Mouse Genome 430 2.0 Array)   1449351_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122047
Ensembl peptide - ENSMUSP00000029652
Ensembl peptide - ENSMUSP00000118970
NCBI entrez gene - 54635     See in Manteia.
MGI - MGI:1859631
RefSeq - NM_019971
RefSeq - XM_006501712
RefSeq Peptide - NP_064355
swissprot - D6RGS6
swissprot - Q8CI19
Ensembl - ENSMUSG00000028019
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfcENSDARG00000077588Danio rerio
 PDGFCENSGALG00000009378Gallus gallus
 PDGFCENSG00000145431Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdgfd / Q925I7 / Mus musculus platelet-derived growth factor, D polypeptide (Pdgfd), transcript variant 2, mRNA. / Q9GZP0* / platelet derived growth factor D*ENSMUSG0000003200643


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR000859  CUB domain
 IPR029034  Cystine-knot cytokine
 IPR029817  Platelet-derived growth factor C
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007596 blood coagulation IBA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009790 embryo development IEA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0030335 positive regulation of cell migration IBA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IBA
 biological_processGO:0043406 positive regulation of MAP kinase activity IBA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway ISO
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048565 digestive tract development IGI
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060348 bone development IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding ISO
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by PDGF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfctm1.1Hdin/Pdgfctm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lifrtm1Imx/Lifrtm1Imx
Genetic Background: involves: 129P3/J * 129S7/SvEvBrd * C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002239 abnormal nasal septum morphology "any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lifrtm1Imx/Lifrtm1Imx
Genetic Background: involves: 129P3/J * 129S7/SvEvBrd * C57BL/6

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: B6.129-Pdgfctm1Nagy Pdgfatm2Cbet

Allelic Composition: Pdgfatm1Cbet/Pdgfa+,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005297 spina bifida occulta "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: B6.129-Pdgfctm1Nagy Pdgfatm2Cbet

Allelic Composition: Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Pdgfctm1.1Hdin/Pdgfctm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

Allelic Composition: Pdgfctm1.1Hdin/Pdgfctm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0009891 abnormal palate bone morphology "any structural anomaly of the maxillary or palatine shelves that comprise the bones of the hard palate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0010406 absent atrial septum "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0014079 decreased small intestinal villus number "fewer than normal numbers of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall" [MGI:Anna, PMID:16679353]
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Allelic Composition: Pdgfatm2Cbet/Pdgfatm2Cbet,Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030203 short nasal septum "reduced length of the dividing wall that runs down the midline of the nose, separating the nasal cavity into the two nostrils" [MGI:anna]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / reaction
 ENSMUSG00000031538 Plat / P11214 / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B / P00750* / plasminogen activator, tissue type*  / reaction
 ENSMUSG00000028019 Pdgfc / Q8CI19 / platelet-derived growth factor, C polypeptide / Q9NRA1* / platelet derived growth factor C*  / complex






 

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