ENSGALG00000014659


Gallus gallus

Features
Gene ID: ENSGALG00000014659
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : C1R / C1ra / C1rb / C1RL / complement C1r / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / complement C1r subcomponent like / Complement C1r subcomponent-like protein / P00736 / Q3UZ09 / Q8CFG9 / Q8CG16 / Q9NZP8
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 77392527
Gene end: 77399415
  
Corresponding Affymetrix probe sets: Gga.9025.1.S1_at (Chicken Array)   GgaAffx.24484.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023583
NCBI entrez gene - 418295     See in Manteia.
RefSeq - XM_416518
swissprot - F1NAB7
Ensembl - ENSGALG00000014659
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 C1RENSG00000159403Homo sapiens
 C1RLENSG00000139178Homo sapiens
 C1raENSMUSG00000055172Mus musculus
 C1rbENSMUSG00000098470Mus musculus
 C1rlENSMUSG00000038527Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MASP1 / mannan-binding lectin serine protease 1 precursor / P48740* / P98064* / mannan binding lectin serine peptidase 1* / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), t...ENSGALG0000000741941
MASP2 / mannan-binding lectin serine protease 2 precursor / O00187* / Q91WP0* / mannan binding lectin serine peptidase 2* / Mannan-binding lectin serine protease 2 Mannan-binding lectin se...ENSGALG0000000301636
C1S / complement C1s subcomponent precursor / C1s1* / C1s2* / Q8CFG8* / P09871* / complement C1s* / complement component 1, s subcomponent 1* / complement component 1, s subcomponent 2*ENSGALG0000001460335
F10 / P25155 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / O88947* / P00742* / coagulation factor X*ENSGALG0000002667720
PAMR1 / peptidase domain containing associated with muscle regeneration 1 / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 *ENSGALG0000000788620
F7 / coagulation factor VII precursor / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSGALG0000001683319
F9 / coagulation factor IX precursor / P00740* / P16294* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSGALG0000000651317
ENSGALG0000004562217
PROC / vitamin K-dependent protein C precursor / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protein C Vitamin K-dependent protein...ENSGALG0000000178016
PROZ / protein Z, vitamin K dependent plasma glycoprotein / P22891* / Q9CQW3*ENSGALG0000001683213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001867 complement activation, lectin pathway IBA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006956 complement activation TAS
 biological_processGO:0006958 complement activation, classical pathway TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Creation of classical C3 convertase
Classical antibody-mediated complement activation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004771 C1QB / complement C1q B chain / P02746* / P14106* / Complement C1q subcomponent subunit B *  / complex
 ENSGALG00000021569 C1QA / complement C1q A chain / P02745* / P98086* / Complement C1q subcomponent subunit A *  / complex
 ENSGALG00000014659 C1R* / C1ra* / C1rb* / C1RL* / Q9NZP8* / P00736* / Q3UZ09* / Q8CFG9* / Q8CG16* / complement C1r* / complement C1r subcomponent like* / Complement C1r subcomponent-like protein * / Complemen...  / complex
 ENSGALG00000029669 C1QC / complement C1q C chain / P02747* / Q02105* / Complement C1q subcomponent subunit C *  / complex






 

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