ENSGALG00000007419


Gallus gallus

Features
Gene ID: ENSGALG00000007419
  
Biological name :MASP1
  
Synonyms : mannan-binding lectin serine protease 1 precursor / MASP1
  
Possible biological names infered from orthology : mannan binding lectin serine peptidase 1 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740 / P98064
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 14910364
Gene end: 14927972
  
Corresponding Affymetrix probe sets: Gga.7840.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057763
Ensembl peptide - ENSGALP00000011986
NCBI entrez gene - 407088     See in Manteia.
RefSeq - XM_015291383
RefSeq - NM_213586
RefSeq Peptide - NP_998751
swissprot - A0A1D5PXR6
swissprot - F1N9E1
Ensembl - ENSGALG00000007419
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 masp1ENSDARG00000068726Danio rerio
 MASP1ENSG00000127241Homo sapiens
 Masp1ENSMUSG00000022887Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MASP2 / mannan-binding lectin serine protease 2 precursor / O00187* / Q91WP0* / mannan binding lectin serine peptidase 2* / Mannan-binding lectin serine protease 2 Mannan-binding lectin se...ENSGALG0000000301641
C1R* / C1ra* / C1rb* / C1RL* / Q9NZP8* / P00736* / Q3UZ09* / Q8CFG9* / Q8CG16* / complement C1r* / complement C1r subcomponent like* / Complement C1r subcomponent-like protein * / Complemen...ENSGALG0000001465940
C1S / complement C1s subcomponent precursor / C1s1* / C1s2* / Q8CFG8* / P09871* / complement C1s* / complement component 1, s subcomponent 1* / complement component 1, s subcomponent 2*ENSGALG0000001460335
PAMR1 / peptidase domain containing associated with muscle regeneration 1 / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 *ENSGALG0000000788621
PROC / vitamin K-dependent protein C precursor / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protein C Vitamin K-dependent protein...ENSGALG0000000178018
F7 / coagulation factor VII precursor / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSGALG0000001683318
F10 / P25155 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / O88947* / P00742* / coagulation factor X*ENSGALG0000002667718
F9 / coagulation factor IX precursor / P00740* / P16294* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSGALG0000000651318
ENSGALG0000004562217
PROZ / protein Z, vitamin K dependent plasma glycoprotein / P22891* / Q9CQW3*ENSGALG0000001683212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001867 complement activation, lectin pathway IEA
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Lectin pathway of complement activation
Initial triggering of complement
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Scavenging by Class A Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002507 MBL2 / Q98TA4 / Mannose-binding protein / Mbl1* / P11226* / P39039* / P41317* / mannose binding lectin 2* / Mannose-binding protein A * / mannose-binding lectin (protein C) 2*  / complex
 ENSGALG00000007419 MASP1 / mannan-binding lectin serine protease 1 precursor / P48740* / P98064* / mannan binding lectin serine peptidase 1* / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), t...  / complex
 ENSGALG00000037309 COLEC11 / collectin-11 precursor / Q9BWP8* / collectin subfamily member 11*  / complex
 ENSGALG00000033144 Q2LK95 / COLEC10 / Collectin-10 / Q8CF98* / Q9Y6Z7* / collectin subfamily member 10*  / complex






 

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