ENSGALG00000003016


Gallus gallus

Features
Gene ID: ENSGALG00000003016
  
Biological name :MASP2
  
Synonyms : mannan-binding lectin serine protease 2 precursor / MASP2
  
Possible biological names infered from orthology : mannan binding lectin serine peptidase 2 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187 / Q91WP0
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 4069606
Gene end: 4082988
  
Corresponding Affymetrix probe sets: Gga.10207.1.S1_at (Chicken Array)   Gga.10207.2.S1_at (Chicken Array)   Gga.10207.2.S1_a_at (Chicken Array)   Gga.11335.1.A1_at (Chicken Array)   Gga.16830.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000004756
Ensembl peptide - ENSGALP00000059174
NCBI entrez gene - 407089     See in Manteia.
RefSeq - XM_015296848
RefSeq - NM_213587
RefSeq - XM_015296846
RefSeq - XM_015296847
RefSeq Peptide - NP_998752
swissprot - F1NAP7
swissprot - Q6Q1Q7
Ensembl - ENSGALG00000003016
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 masp2ENSDARG00000007988Danio rerio
 MASP2ENSG00000009724Homo sapiens
 Masp2ENSMUSG00000028979Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MASP1 / mannan-binding lectin serine protease 1 precursor / P48740* / P98064* / mannan binding lectin serine peptidase 1* / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), t...ENSGALG0000000741944
C1R* / C1ra* / C1rb* / C1RL* / Q9NZP8* / P00736* / Q3UZ09* / Q8CFG9* / Q8CG16* / complement C1r* / complement C1r subcomponent like* / Complement C1r subcomponent-like protein * / Complemen...ENSGALG0000001465938
C1S / complement C1s subcomponent precursor / C1s1* / C1s2* / Q8CFG8* / P09871* / complement C1s* / complement component 1, s subcomponent 1* / complement component 1, s subcomponent 2*ENSGALG0000001460335
PAMR1 / peptidase domain containing associated with muscle regeneration 1 / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 *ENSGALG0000000788621
F7 / coagulation factor VII precursor / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSGALG0000001683319
PROC / vitamin K-dependent protein C precursor / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protein C Vitamin K-dependent protein...ENSGALG0000000178018
F10 / P25155 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / O88947* / P00742* / coagulation factor X*ENSGALG0000002667718
F9 / coagulation factor IX precursor / P00740* / P16294* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSGALG0000000651317
ENSGALG0000004562216
PROZ / protein Z, vitamin K dependent plasma glycoprotein / P22891* / Q9CQW3*ENSGALG0000001683213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001867 complement activation, lectin pathway TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006956 complement activation TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0001855 complement component C4b binding IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Lectin pathway of complement activation
Initial triggering of complement
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Creation of classical C3 convertase
Lectin-mediated initiation of complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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