ENSDARG00000044356


Danio rerio

Features
Gene ID: ENSDARG00000044356
  
Biological name :tp63
  
Synonyms : tp63 / tumor protein p63
  
Possible biological names infered from orthology : O88898 / Q9H3D4 / transformation related protein 63 / Trp63
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 28795780
Gene end: 28914225
  
Corresponding Affymetrix probe sets: Dr.19227.1.S1_at (Zebrafish Array)   Dr.19227.3.S1_a_at (Zebrafish Array)   NM_152986_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000108362
Ensembl peptide - ENSDARP00000155750
Ensembl peptide - ENSDARP00000140981
Ensembl peptide - ENSDARP00000132905
Ensembl peptide - ENSDARP00000065134
Ensembl peptide - ENSDARP00000065136
Ensembl peptide - ENSDARP00000106582
Ensembl peptide - ENSDARP00000107767
NCBI entrez gene - 260407     See in Manteia.
RefSeq - NM_152248
RefSeq - NM_152986
RefSeq Peptide - NP_689454
RefSeq Peptide - NP_694518
swissprot - F1QLJ1
swissprot - Q6DG24
swissprot - Q8JFE3
swissprot - E9QG65
swissprot - A0A0R4IZ80
swissprot - A0A0R4IHL8
swissprot - F1QKD5
ZFIN ID - ZDB-GENE-030819-1
Ensembl - ENSDARG00000044356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TP63ENSGALG00000007324Gallus gallus
 TP63ENSG00000073282Homo sapiens
 Trp63ENSMUSG00000022510Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tp73 / tumor protein p73 / Trp73* / Q9JJP2* / O15350* / transformation related protein 73*ENSDARG0000001795352
tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*ENSDARG0000003555927


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002117  p53 tumour suppressor family
 IPR008967  p53-like transcription factor, DNA-binding
 IPR010991  p53, tetramerisation domain
 IPR011615  p53, DNA-binding domain
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032645  Tumour protein p63


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010165 response to X-ray IBA
 biological_processGO:0010332 response to gamma radiation IBA
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IBA
 biological_processGO:0032502 developmental process IEA
 biological_processGO:0034644 cellular response to UV IBA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043523 regulation of neuron apoptotic process IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0048730 epidermis morphogenesis IMP
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0030425 dendrite IBA
 molecular_functionGO:0002039 p53 binding IBA
 molecular_functionGO:0003677 DNA binding IPI
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003684 damaged DNA binding IBA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001185 periderm periderm cell decreased amount , abnormal
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 ZFA:0005792 jaw flap jaw flap breeding tubercle decreased size , abnormal
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 ZFA:0005798 jaw row breeding tubercle jaw row breeding tubercle decreased size , abnormal
jaw row breeding tubercle decreased amount , abnormal
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 ZFA:0009041 peridermal cell peridermal cell increased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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