ENSGALG00000007324


Gallus gallus

Features
Gene ID: ENSGALG00000007324
  
Biological name :TP63
  
Synonyms : TP63 / tumor protein 63
  
Possible biological names infered from orthology : O88898 / Q9H3D4 / transformation related protein 63 / Trp63 / tumor protein p63
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 14094193
Gene end: 14188390
  
Corresponding Affymetrix probe sets: Gga.4019.1.S1_at (Chicken Array)   GgaAffx.22207.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000062182
Ensembl peptide - ENSGALP00000032705
NCBI entrez gene - 374269     See in Manteia.
RefSeq - XM_015291367
RefSeq - XM_015291363
RefSeq - XM_015291364
RefSeq - XM_015291366
RefSeq - NM_204351
RefSeq - XM_015291361
RefSeq - XM_015291362
RefSeq Peptide - NP_989682
swissprot - F1NWD0
swissprot - A0A167VDT2
Ensembl - ENSGALG00000007324
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tp63ENSDARG00000044356Danio rerio
 TP63ENSG00000073282Homo sapiens
 Trp63ENSMUSG00000022510Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TP73 / tumor protein p73 / Trp73* / Q9JJP2* / O15350* / transformation related protein 73*ENSGALG0000000100651


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002117  p53 tumour suppressor family
 IPR008967  p53-like transcription factor, DNA-binding
 IPR010991  p53, tetramerisation domain
 IPR011615  p53, DNA-binding domain
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032645  Tumour protein p63


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001736 establishment of planar polarity IEA
 biological_processGO:0001738 morphogenesis of a polarized epithelium IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0002064 epithelial cell development IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007499 ectoderm and mesoderm interaction IEA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0009913 epidermal cell differentiation IEA
 biological_processGO:0009954 proximal/distal pattern formation IEA
 biological_processGO:0010259 multicellular organism aging IEA
 biological_processGO:0010481 epidermal cell division IEA
 biological_processGO:0010482 regulation of epidermal cell division IEA
 biological_processGO:0010838 positive regulation of keratinocyte proliferation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030850 prostate gland development IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0030859 polarized epithelial cell differentiation IEA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0032502 developmental process IEA
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0036342 post-anal tail morphogenesis IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043589 skin morphogenesis IEA
 biological_processGO:0043616 keratinocyte proliferation IEA
 biological_processGO:0045617 negative regulation of keratinocyte differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048485 sympathetic nervous system development IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IEA
 biological_processGO:0048745 smooth muscle tissue development IEA
 biological_processGO:0048807 female genitalia morphogenesis IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0060157 urinary bladder development IEA
 biological_processGO:0060197 cloacal septation IEA
 biological_processGO:0060513 prostatic bud formation IEA
 biological_processGO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development IEA
 biological_processGO:0061436 establishment of skin barrier IEA
 biological_processGO:0098773 skin epidermis development IEA
 biological_processGO:1904674 positive regulation of somatic stem cell population maintenance IEA
 biological_processGO:1904888 cranial skeletal system development IEA
 biological_processGO:2000271 positive regulation of fibroblast apoptotic process IEA
 biological_processGO:2000381 negative regulation of mesoderm development IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0050699 WW domain binding IEA
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011548 PPP1R13B / protein phosphatase 1 regulatory subunit 13B / Q62415* / Q96KQ4* / protein phosphatase 1, regulatory (inhibitor) subunit 13B*  / complex / reaction
 ENSGALG00000007324 TP63 / tumor protein 63 / Trp63* / O88898* / Q9H3D4* / tumor protein p63* / transformation related protein 63*  / complex






 

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