12578


Mus musculus (NCBI)
regulationproteincellactivitytranscriptionbindingapoptoticprocesscyclekinaseproliferationresponsedna-templatedfactorcellularcyclin-dependentserinethreoninemitochondrioninvolveddnapnucleustransferasesenescenceinhibitorgtransitionmitoticrrna

Features
Gene ID: 12578
  
Biological name :
  
Synonyms : ARF-INK4a|Arf|INK4a-ARF|Ink4a/Arf|MTS1|Pctr1|p16|p16(INK4a)|p16INK4a|p19|p19ARF / Cdkn2a / cyclin dependent kinase inhibitor 2A
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1450140_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - NP_001035744.1
RefSeq - NP_034007.1
RefSeq - NC_000070.6
RefSeq - 6753390
RefSeq - 98986447
RefSeq - NM_001040654.1
RefSeq - NM_009877.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000044303 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell cyclecatabolic processcellular component organizationprocess utilizing autophagic mechanismcell adhesionbiosynthetic processcellular component biogenesiscell deathagingcellular developmental processanatomical structure developmentresponse to chemicalcell growthcell activationleukocyte proliferationregulation of biological qualityepithelial cell proliferationmaintenance of cell numberresponse to stresscell communicationcellular response to stimulusestablishment of localizationcellular localizationmacromolecule localizationcell divisiontissue remodelingnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell cyclecatabolic processcellular component organizationprocess utilizing autophagic mechanismcell adhesionbiosynthetic processcellular component biogenesiscell deathagingcellular developmental processanatomical structure developmentresponse to chemicalcell growthcell activationleukocyte proliferationregulation of biological qualityepithelial cell proliferationmaintenance of cell numberresponse to stresscell communicationcellular response to stimulusestablishment of localizationcellular localizationmacromolecule localizationcell divisiontissue remodelingnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell cyclecatabolic processcellular component organizationprocess utilizing autophagic mechanismcell adhesionbiosynthetic processcellular component biogenesiscell deathagingcellular developmental processanatomical structure developmentresponse to chemicalcell growthcell activationleukocyte proliferationregulation of biological qualityepithelial cell proliferationmaintenance of cell numberresponse to stresscell communicationcellular response to stimulusestablishment of localizationcellular localizationmacromolecule localizationcell divisiontissue remodelingnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell cyclecatabolic processcellular component organizationprocess utilizing autophagic mechanismcell adhesionbiosynthetic processcellular component biogenesiscell deathagingcellular developmental processanatomical structure developmentresponse to chemicalcell growthcell activationleukocyte proliferationregulation of biological qualityepithelial cell proliferationmaintenance of cell numberresponse to stresscell communicationcellular response to stimulusestablishment of localizationcellular localizationmacromolecule localizationcell divisiontissue remodelingnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell cyclecatabolic processcellular component organizationprocess utilizing autophagic mechanismcell adhesionbiosynthetic processcellular component biogenesiscell deathagingcellular developmental processanatomical structure developmentresponse to chemicalcell growthcell activationleukocyte proliferationregulation of biological qualityepithelial cell proliferationmaintenance of cell numberresponse to stresscell communicationcellular response to stimulusestablishment of localizationcellular localizationmacromolecule localizationcell divisiontissue remodelingnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell cyclecatabolic processcellular component organizationprocess utilizing autophagic mechanismcell adhesionbiosynthetic processcellular component biogenesiscell deathagingcellular developmental processanatomical structure developmentresponse to chemicalcell growthcell activationleukocyte proliferationregulation of biological qualityepithelial cell proliferationmaintenance of cell numberresponse to stresscell communicationcellular response to stimulusestablishment of localizationcellular localizationmacromolecule localizationcell divisiontissue remodelingnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell cyclecatabolic processcellular component organizationprocess utilizing autophagic mechanismcell adhesionbiosynthetic processcellular component biogenesiscell deathagingcellular developmental processanatomical structure developmentresponse to chemicalcell growthcell activationleukocyte proliferationregulation of biological qualityepithelial cell proliferationmaintenance of cell numberresponse to stresscell communicationcellular response to stimulusestablishment of localizationcellular localizationmacromolecule localizationcell divisiontissue remodelingnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell cyclecatabolic processcellular component organizationprocess utilizing autophagic mechanismcell adhesionbiosynthetic processcellular component biogenesiscell deathagingcellular developmental processanatomical structure developmentresponse to chemicalcell growthcell activationleukocyte proliferationregulation of biological qualityepithelial cell proliferationmaintenance of cell numberresponse to stresscell communicationcellular response to stimulusestablishment of localizationcellular localizationmacromolecule localizationcell divisiontissue remodelingnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell cyclecatabolic processcellular component organizationprocess utilizing autophagic mechanismcell adhesionbiosynthetic processcellular component biogenesiscell deathagingcellular developmental processanatomical structure developmentresponse to chemicalcell growthcell activationleukocyte proliferationregulation of biological qualityepithelial cell proliferationmaintenance of cell numberresponse to stresscell communicationcellular response to stimulusestablishment of localizationcellular localizationmacromolecule localizationcell divisiontissue remodelingnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell cyclecatabolic processcellular component organizationprocess utilizing autophagic mechanismcell adhesionbiosynthetic processcellular component biogenesiscell deathagingcellular developmental processanatomical structure developmentresponse to chemicalcell growthcell activationleukocyte proliferationregulation of biological qualityepithelial cell proliferationmaintenance of cell numberresponse to stresscell communicationcellular response to stimulusestablishment of localizationcellular localizationmacromolecule localizationcell divisiontissue remodelingnitrnitrogen compound metabolic processcellcellular metabolic processprimprimary metabolic processreguregulation of molecular functionorgaorganic substance metabolic processcellcell cyclecatacatabolic processcellcellular component organizationprocprocess utilizing autophagic mechanismcellcell adhesionbiosbiosynthetic processcellcellular component biogenesiscellcell deathaginagingcellcellular developmental processanatanatomical structure developmentrespresponse to chemicalcellcell growthcellcell activationleukleukocyte proliferationreguregulation of biological qualityepitepithelial cell proliferationmainmaintenance of cell numberrespresponse to stresscellcell communicationcellcellular response to stimulusestaestablishment of localizationcellcellular localizationmacrmacromolecule localizationcellcell divisiontisstissue remodeling
protein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityenzyme regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityenzyme regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityenzyme regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityenzyme regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityenzyme regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityenzyme regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityenzyme regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityenzyme regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityenzyme regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityenzyme regulator activitycatalytic activity, acting on a proteintransferase activityprotein bindingprotein bindingorganic cyclic compoorganic cyclic compound bindingheterocyclic compounheterocyclic compound bindingDNA-binding transcriDNA-binding transcription factor activityenzyme regulator actenzyme regulator activitycatalytic activity, catalytic activity, acting on a proteintransferase activitytransferase activity
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0000082 G1/S transition of mitotic cell cycle ISO
 biological_processGO:0000209 protein polyubiquitination ISO
 biological_processGO:0000422 autophagy of mitochondrion ISO
 biological_processGO:0001953 negative regulation of cell-matrix adhesion ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006469 negative regulation of protein kinase activity ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest ISO
 biological_processGO:0007568 aging IMP
 biological_processGO:0007569 cell aging IDA
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0008637 apoptotic mitochondrial changes ISO
 biological_processGO:0009303 rRNA transcription IGI
 biological_processGO:0010243 response to organonitrogen compound ISO
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle ISO
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0014070 response to organic cyclic compound ISO
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0030889 negative regulation of B cell proliferation IMP
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0031648 protein destabilization ISO
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0033088 negative regulation of immature T cell proliferation in thymus IMP
 biological_processGO:0033235 positive regulation of protein sumoylation ISO
 biological_processGO:0033600 negative regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IGI
 biological_processGO:0035019 somatic stem cell population maintenance IGI
 biological_processGO:0035986 senescence-associated heterochromatin focus assembly ISO
 biological_processGO:0042326 negative regulation of phosphorylation ISO
 biological_processGO:0042493 response to drug ISO
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046822 regulation of nucleocytoplasmic transport IGI
 biological_processGO:0046825 regulation of protein export from nucleus ISO
 biological_processGO:0048103 somatic stem cell division IMP
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity IDA
 biological_processGO:0051882 mitochondrial depolarization ISO
 biological_processGO:0060058 positive regulation of apoptotic process involved in mammary gland involution IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0070534 protein K63-linked ubiquitination ISO
 biological_processGO:0071158 positive regulation of cell cycle arrest ISO
 biological_processGO:0090398 cellular senescence ISO
 biological_processGO:0090399 replicative senescence ISO
 biological_processGO:1900182 positive regulation of protein localization to nucleus ISO
 biological_processGO:1901798 positive regulation of signal transduction by p53 class mediator ISO
 biological_processGO:1902510 regulation of apoptotic DNA fragmentation ISO
 biological_processGO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process ISO
 biological_processGO:1903214 regulation of protein targeting to mitochondrion ISO
 biological_processGO:1904667 negative regulation of ubiquitin protein ligase activity ISO
 biological_processGO:1990000 amyloid fibril formation ISO
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process ISO
 biological_processGO:2000111 positive regulation of macrophage apoptotic process IGI
 biological_processGO:2000346 negative regulation of hepatocyte proliferation ISO
 biological_processGO:2000435 negative regulation of protein neddylation ISO
 biological_processGO:2000774 positive regulation of cellular senescence ISO
 cellular_componentGO:0001652 granular component IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0032991 protein-containing complex ISO
 cellular_componentGO:0035985 senescence-associated heterochromatin focus ISO
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019789 SUMO transferase activity ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0051059 NF-kappaB binding ISO
 molecular_functionGO:0055105 ubiquitin-protein transferase inhibitor activity IDA
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding ISO
 molecular_functionGO:0097718 disordered domain specific binding ISO
 molecular_functionGO:1990948 ubiquitin ligase inhibitor activity ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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