Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0000351	increased cell proliferation	"greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dicer1^tm1Snj/Dicer1^tm1Snj Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Gt(ROSA)26Sor^{tm1.1(MYC/ERT2)Gev}/Gt(ROSA)26Sor^{tm1.1(MYC/ERT2)Gev} Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Lig4^tm1Fwa/Lig4^tm1Fwa Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Lig4^tm1Fwa/Lig4^tm1Fwa Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0000477	abnormal intestine morphology	"malformation of the digestive tube passing from the stomach to the anus" [J:48968]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Rnf2^tm1Mvi/Rnf2^tm1Mvi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a⁺,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd
MP:0000611	jaundice	"clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
MP:0000662	abnormal branching of the mammary ductal tree	"anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cav1^tm1Mls/Cav1^tm1Mls,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Rnf2^tm1Mvi/Rnf2^tm1Mvi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pgr^{tm3(rtTA2SM2)Lyd}/Pgr^{tm3(rtTA2SM2)Lyd} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000708	thymus hyperplasia	"increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Phc1^tm1Os/Phc1^tm1Os,Tg(Myh7-Phc1)#Yota/0 Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000729	abnormal myogenesis	"anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ski^tm1Cco/Ski^tm1Cco Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000730	increased number of satellite cells	"greater number of unfused cells in muscle that play a role in muscle regeneration" [J:42574]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Mt1-HGFSF)19Lmb/0 Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL
MP:0000753	paralysis	"loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-BRAFV600E)470Fgh/0 Genetic Background:* involves: 129/Sv * C57BL/6J * CBA * SJL
MP:0000755	hindlimb paralysis	"loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0001004	abnormal photoreceptor morphology	"structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: FVB.Cg-Cdkn2a^tm1Rdp
MP:0001158	abnormal prostate morphology	"mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(tetO-BRAFV600E)29Lc/0,Tg(Tyr-rtTA)37Lc/0 Genetic Background:* involves: 129/Sv * C57BL/6J * SJL
MP:0001182	lung hemorrhage	"bleeding in the respiratory organs" [J:66345]	Show Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0001188	hyperpigmentation	"excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53⁺,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-NRASQ61K)1Bee/0 Genetic Background:* involves: 129/Sv * C57BL/6J * DBA/2 * SJL Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Nras^tm1Tyj/Nras^tm1Tyj,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: B6J.Cg-Nras^tm1Tyj Cdkn2a^tm2.1Nesh Tg(Tyr-cre/ERT2)13Bos Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Nras^tm1.1Nesh/Nras^tm1.1Nesh,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: B6J.Cg-Nras^tm1.1Nesh Cdkn2a^tm2.1Nesh Tg(Tyr-cre/ERT2)13Bos Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: B6J.Cg-Cdkn2a^tm2.1Nesh Kras^tm4Tyj Tg(Tyr-cre/ERT2)13Bos
MP:0001212	skin lesions	"focal patches of inflammation on the skin" [J:30162]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-NRASQ61K)1Bee/0 Genetic Background:* involves: 129/Sv * C57BL/6J * DBA/2 * SJL
MP:0001222	epidermal hyperplasia	"increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,E4f1^tm1Pisc/E4f1^tm1.1Llca,Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,E4f1^tm1Pisc/E4f1^tm1.1Llca,Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0001270	distended abdomen	"abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
MP:0001272	increased metastatic potential		Show Allelic Composition: Hfe^tm2Nca/Hfe^tm2Nca,Urod^tm1Kush/Urod⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-NRASQ61K)1Bee/? Genetic Background:* involves: 129/Sv * C57BL/6 * DBA/2 * SJL Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Genetic Background: involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a⁺,Nf2^tm2Gth/Nf2^tm2Gth,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Tg(CAG-Bgeo,-tTA,-EGFP)2A11Kuw/0,Tg(Pdx1-cre)6Tuv/0,Tg(tetO-MYC)36Bop/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Nras^tm1.1Nesh/Nras^tm1.1Nesh,Stk11^tm1.1Rdp/Stk11^tm1.1Rdp,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: B6J.Cg-Nras^tm1.1Nesh Cdkn2a^tm2.1Nesh Stk11^tm1.1Rdp Tg(Tyr-cre/ERT2)13Bos
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: FVB.Cg-Cdkn2a^tm1Rdp Allelic Composition: Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cdkn2a^{tm1a(EUCOMM)Wtsi}/Cdkn2a^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cdkn2a^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001304	cataracts	"complete or partial opacity of the lens" [J:65031]	Show Allelic Composition: Etl4^{Gt(6LSN)6029Gos}/Etl4^{Gt(6LSN)6029Gos},Etn2^Sd/Etn2⁺ Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * NMRI Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,X/Tg(Tyr-HRAS)60Lc Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * FVB/N * SJL Allelic Composition: Cdkn2a^{tm1a(EUCOMM)Wtsi}/Cdkn2a^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cdkn2a^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Apc^tm2Cip/Apc⁺,Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Rnf2^tm1Mvl/Rnf2^tm1Mvl Genetic Background: involves: 129P2/Ola * 129/Sv * C57BL/6J * FVB/N * SJL
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Rnf2^tm1Mvl/Rnf2⁺ Genetic Background: involves: 129/Ola * FVB
MP:0001885	mammary ductal hyperplasia		Show Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Myl2^tm1(cre)Krc/Myl2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Inpp5d^tm1Dmt/Inpp5d^tm1Dmt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(GFAP-TVA)10Ech/0 Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-BRAFV600E)470Fgh/0 Genetic Background:* involves: 129/Sv * C57BL/6J * CBA * SJL
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Lat^tm1Les/Lat^tm1Les,Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak} Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002001	blindness	"loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gli3^Pdn/Gli3^Pdn Genetic Background: involves: Jcl:ICR Allelic Composition: Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002014	papilloma	"benign epithelial tumor" [J:47225]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Genetic Background: involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd
MP:0002018	malignant tumors	"higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]	Show Allelic Composition: Hfe^tm2Nca/Hfe^tm2Nca,Urod^tm1Kush/Urod⁺ Genetic Background: involves: C57BL/6J
MP:0002019	abnormal tumor incidence	"deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn2a^tm1Sxs/Cdkn2a^tm1Sxs Genetic Background: involves: 129/Sv * C57BL/6
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Mt1-HGFSF)19Lmb/0 Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Mxi1^tm1Rdp/Mxi1^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)76Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)68Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Genetic Background: involves: 129 * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Nf2^tm2Gth/Nf2⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a⁺,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a⁺,Nf2^tm2Gth/Nf2^tm2Gth,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0002023	B cell derived lymphoma	"heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0002024	T cell derived lymphoma	"group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002026	leukemia	"progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)76Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)68Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Nf2^tm2Gth/Nf2⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a⁺,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd
MP:0002027	lung adenocarcinoma	"malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)76Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)68Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129S4/SvJae Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-Kras2)12Hev/0 Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL
MP:0002030	neurofibrosarcoma	"malignant neoplasm of fibrous tissue of the nervous system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Tg(Tyr-cre/ERT,-Hras1,-Trap1a)10BJvde/0 Genetic Background:* involves: C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Nf1^tm1Par/Nf1^tm1Par Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002032	sarcoma	"connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)76Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)68Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺,Pdgfra^tm12Sor/Pdgfra⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Nf1^tm1Par/Nf1^tm1Par Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Pax7^tm1Pgr/Pax7^tm1Pgr,Tg(CKMM-tTA)A3Rhvh/0,Tg(tetO-Hgf,-EGFP)24Tcre/0 Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * FVB Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Pax7^tm1Pgr/Pax7⁺,Tg(CKMM-tTA)A3Rhvh/0,Tg(tetO-Hgf,-EGFP)24Tcre/0 Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * FVB
MP:0002036	rhabdomyosarcoma	"malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Mt1-HGFSF)19Lmb/0 Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Myf6^tm1(cre)Mrc/Myf6⁺,Pax3^tm1Mrc/Pax3^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a⁺,Nf2^tm2Gth/Nf2^tm2Gth,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Nf1^tm1Par/Nf1^tm1Par Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(CKMM-tTA)A3Rhvh/0,Tg(tetO-Hgf,-EGFP)24Tcre/0 Genetic Background: involves: 129X1/SvJ * FVB Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a⁺,Tg(CKMM-tTA)A3Rhvh/0,Tg(tetO-Hgf,-EGFP)24Tcre/0 Genetic Background: involves: 129X1/SvJ * FVB Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Pax7^tm1Pgr/Pax7^tm1Pgr,Tg(CKMM-tTA)A3Rhvh/0,Tg(tetO-Hgf,-EGFP)24Tcre/0 Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * FVB Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Pax7^tm1Pgr/Pax7⁺,Tg(CKMM-tTA)A3Rhvh/0,Tg(tetO-Hgf,-EGFP)24Tcre/0 Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * FVB
MP:0002037	fibrohistocytoma	"slowly growing skin nodule derived from cellular fibrous tissue; often surrounds capillaries" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002038	carcinoma	"malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Genetic Background: involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tacstd2^tm1Lsm/Tacstd2^tm1Lsm Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Braf^tm1.1Brd/Braf⁺,Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL
MP:0002052	decreased tumor incidence	"less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kif1c^Orch3-DBA/2J/Kif1c^Orch3-DBA/2J Genetic Background: involves: BALB/cByJ * DBA/2 Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a⁺,Ppm1d^tm1Lad/Ppm1d^tm1Lad,Tg(IghMyc)22Bri/0 Genetic Background: involves: 129 * C57BL * FVB/N * SJL
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Timp1^tm1Pds/Y Genetic Background: involves: 129S4/SvJae
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hfe^tm2Nca/Hfe^tm2Nca,Urod^tm1Kush/Urod⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)76Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)68Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Genetic Background: involves: 129 * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Genetic Background: involves: 129 * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a⁺,Ppm1d^tm1Lad/Ppm1d^tm1Lad,Tg(IghMyc)22Bri/0 Genetic Background: involves: 129 * C57BL * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Rnf2^tm1Mvi/Rnf2^tm1Mvi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(S100b-v-erbB)4496Waw/0 Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(tetO-BRAFV600E)29Lc/0,Tg(Tyr-rtTA)37Lc/0 Genetic Background:* involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Tg(GFAP-TVA)5Hev/0 Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(GFAP-TVA)5Hev/0 Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(GFAP-TVA)5Hev/0 Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm1(CAG-EGFR)Char},Pten^tm1Hwu/Pten^tm1Hwu Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Col1a1^{tm2(CAG-EGFR)Char}/Col1a1^{tm2(CAG-EGFR)Char},Pten^tm1Hwu/Pten^tm1Hwu Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm2(CAG-EGFR)Char},Pten^tm1Hwu/Pten^tm1Hwu Genetic Background:* involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Nf2^tm2Gth/Nf2⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a⁺,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-BRAFV600E)470Fgh/0 Genetic Background:* involves: 129/Sv * C57BL/6J * CBA * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-BRAFV600E)476Fgh/0 Genetic Background:* involves: 129/Sv * C57BL/6J * CBA * SJL Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,X/Tg(Tyr-HRAS)60Lc Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL Allelic Composition: Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Tg(CAG-Bgeo,-tTA,-EGFP)2A11Kuw/0,Tg(Pdx1-cre)6Tuv/0,Tg(tetO-MYC)36Bop/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺ Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nefm^tm1Jpj/Nefm^tm1Jpj Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Cdkn2a^tm1Sxs/Cdkn2a^tm1Sxs Genetic Background: involves: 129/Sv * C57BL/6
MP:0002356	abnormal spleen red pulp morphology	"anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0002399	abnormal pluripotent precursor cell morphology/development	"anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pknox1^tm1Fbla/Pknox1^tm1Fbla Genetic Background: B6.Cg-Pknox1^tm1Fbla
MP:0002404	intestinal adenoma	"benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Braf^tm1.1Brd/Braf⁺,Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Apc^tm2Cip/Apc⁺,Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
MP:0002673	abnormal sperm count	"increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gli3^Pdn/Gli3^Pdn Genetic Background: involves: Jcl:ICR
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^em2Cjs/Cdkn2a^em2Cjs Genetic Background: C57BL/6-Cdkn2a^em2Cjs
MP:0002699	abnormal vitreous body	"anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0002724	enhanced wound healing	"increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tacstd2^tm1Lsm/Tacstd2^tm1Lsm Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0002877	abnormal melanocyte morphology	"malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53⁺,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cav1^tm1Mls/Cav1^tm1Mls,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0003099	retinal detachment	"detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^em2Cjs/Cdkn2a^em2Cjs Genetic Background: C57BL/6-Cdkn2a^em2Cjs
MP:0003155	abnormal telomere length	"abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0003203	increased neuron apoptosis	"increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Lig4^tm1Fwa/Lig4^tm1Fwa Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL
MP:0003205	testicular atrophy	"wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gli3^Pdn/Gli3^Pdn Genetic Background: involves: Jcl:ICR Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Rnf2^tm1Mvl/Rnf2^tm1Mvl Genetic Background: involves: 129P2/Ola * 129/Sv * C57BL/6J * FVB/N * SJL
MP:0003236	abnormal lens capsule morphology	"malformation in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0003336	pancreatic cysts	"the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras^tm4Tyj,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0003447	reduced tumor growth/size	"less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,X/Tg(Tyr-HRAS)60Lc Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL
MP:0003453	abnormal keratinocyte physiology	"atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]	Show Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,E4f1^tm1Pisc/E4f1^tm1.1Llca,Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
MP:0003570	uterine leiomyoma	"a benign tumor derived from the smooth muscle tissue of the uterus" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Nf2^tm2Gth/Nf2⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a⁺,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Atr^tm2Bal/Atr^tm2Bal,Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
MP:0003667	hemangiosarcoma	"a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0003721	increased tumor growth/size	"greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Genetic Background: involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB
MP:0003733	abnormal inner nuclear layer morphology	"malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003786	premature aging	"earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0003789	osteosarcoma	"malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)76Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)68Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0003851	skeletal muscle interstitial fibrosis	"formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺,Pdgfra^tm12Sor/Pdgfra⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL
MP:0003934	abnormal pancreas development	"anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N
MP:0003941	abnormal skin development	"anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tacstd2^tm1Lsm/Tacstd2^tm1Lsm Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0004046	abnormal mitosis	"anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn,Hdac2^tm1.2Rdp/Hdac2^tm1.2Rdp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0004207	squamous cell carcinoma	"a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Genetic Background: involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL
MP:0004227	increased cellular sensitivity to ionizing radiation	"increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Lig4^tm1Fwa/Lig4^tm1Fwa Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Cdkn2b^tm2Brn/Cdkn2b^tm2Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Genetic Background: involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Braf^tm1Cpri/Braf^tm1Cpri,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL
MP:0004500	increased incidence of ionizing radiation-induced tumors	"higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004501	increased incidence of UV-induced tumors	"higher than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,X/Tg(Tyr-HRAS)60Lc Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * FVB/N * SJL
MP:0004502	decreased incidence of chemically-induced tumors	"lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Cdkn2b^tm2Brn/Cdkn2b^tm2Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0004851	increased testis weight	"greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ticam1^M3Btlr/Ticam1⁺ Genetic Background: C57BL/6J-Ticam1^M3Btlr
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Genetic Background: involves: 129X1/SvJ
MP:0004955	increased thymus weight	"greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0005091	increased double-positive T cell count	"greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn,Apc^tm2Cip/Apc⁺,Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
MP:0005195	abnormal posterior eye segment morphology	"anomalous structure of any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: FVB.Cg-Cdkn2a^tm1Rdp
MP:0005241	abnormal retinal ganglion layer morphology	"anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005266	abnormal metabolism	"anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kras^tm4Tyj/Kras^tm4Tyj,Trim33^tm1Los/Trim33^tm1Los,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
MP:0005324	ascites	"accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
MP:0005501	abnormal skin physiology	"atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rb1^tm1Tyj/Rb1^tm1Tyj,Tg(Rb1)1Blg/0,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL
MP:0005545	abnormal lens development	"aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: FVB.Cg-Cdkn2a^tm1Rdp
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL
MP:0005623	abnormal meninges	"anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, smb:Susan M. Bello , Mouse Genome Informatics Curator, J:48079]	Show Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0006069	abnormal retinal neuronal layer morphology	"malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: FVB.Cg-Cdkn2a^tm1Rdp
MP:0006148	binocular blindness	"loss of vision in both eyes, may be transient" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^em2Cjs/Cdkn2a^em2Cjs Genetic Background: C57BL/6-Cdkn2a^em2Cjs
MP:0006379	abnormal spermatocyte morphology	"anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^em2Cjs/Cdkn2a^em2Cjs Genetic Background: C57BL/6-Cdkn2a^em2Cjs
MP:0006410	abnormal common myeloid progenitor cell morphology	"anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Rnf2^tm1Mvi/Rnf2^tm1Mvi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL
MP:0008009	delayed cellular replicative senescence	"slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL
MP:0008014	lung tumor	"presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Braf^tm1Mmcm/Braf⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-Kras2)12Hev/0 Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL
MP:0008019	liver tumor	"presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0008280	male germ cell apoptosis	"presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0008478	increased spleen white pulp amount	"increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0008714	lung carcinoma	"a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0009043	pancreas adenoma	"a benign epithelial neoplasm located in the pancreas" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
MP:0009151	pancreatic ductal adenocarcinoma	"adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750]	Show Allelic Composition: Hfe^tm2Nca/Hfe^tm2Nca,Urod^tm1Kush/Urod⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Genetic Background: involves: 129 * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Genetic Background: involves: 129 * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Tg(CAG-Bgeo,-tTA,-EGFP)2A11Kuw/0,Tg(Pdx1-cre)6Tuv/0,Tg(tetO-MYC)36Bop/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
MP:0009152	pancreatic intraepithelial neoplasia	"noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct" [PMID:11342768]	Show Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
MP:0009153	pancreas tumor	"tumors or cancer of the pancreas" [MESH:C04.588.274.761]	Show Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras^tm4Tyj,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Tg(CAG-Bgeo,-tTA,-EGFP)2A11Kuw/0,Tg(Pdx1-cre)6Tuv/0,Tg(tetO-MYC)36Bop/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
MP:0009220	prostate adenocarcinoma	"malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(tetO-BRAFV600E)29Lc/0,Tg(Tyr-rtTA)37Lc/0 Genetic Background:* involves: 129/Sv * C57BL/6J * SJL
MP:0009277	brain tumor	"presence of abnormal rapidly proliferating cells in the brain, usually in the form of a distinct mass" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otc^spf-J/Y Genetic Background: C57BL/6J-Otc^spf-J/J
MP:0009308	adenocarcinoma	"malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Kras^tm4Tyj/Kras⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
MP:0009319	small lymphocytic lymphoma	"lymphocytic leukemia where the lymphocytes are not increased in the peripheral blood, but lymph nodes are enlarged and other lymphoid tissue or bone marrow is infiltrated by small lymphocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0009321	histiocytic sarcoma		Show Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0009336	increased splenocyte proliferation	"increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0009459	skeletal muscle hyperplasia	"overdevelopment or increased size of the skeletal muscle, usually due an increased number of cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(CKMM-tTA)A3Rhvh/0,Tg(tetO-Hgf,-EGFP)24Tcre/0 Genetic Background: involves: 129X1/SvJ * FVB
MP:0009503	abnormal mammary gland duct morphology	"any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cav1^tm1Mls/Cav1^tm1Mls,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0009515	gastrointestinal stromal tumor	"non-epithelial, mesenchymal tumors of the gastrointestinal tract, thought to originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract; approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum; GISTs are tumors of connective tissue, i.e. sarcomas, account for 1-3% of all gastrointestinal malignancies in human, and are typically more cellular than other gastrointestinal sarcomas" [http://en.wikipedia.org/wiki/Gastrointestinal_stromal_tumor, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", OMIM:606764]	Show Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0009583	increased keratinocyte proliferation	"increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tacstd2^tm1Lsm/Tacstd2^tm1Lsm Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0009621	primary vitreous hyperplasia	"overdevelopment or increased size of the primary vitreous, usually due an increased number of cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs,Tgfb2^tm1Doe/Tgfb2^tm1Doe Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs,Tgfb2^tm1Doe/Tgfb2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Cdkn2a^tm1Sxs/Cdkn2a^tm1Sxs Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Cdkn2a^tm1Sxs/Cdkn2a⁺,Tgfb2^tm1Doe/Tgfb2^tm1Doe Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a⁺,Tgfb2^tm1Doe/Tgfb2^tm1Doe Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0009704	skin squamous cell carcinoma	"a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tacstd2^tm1Lsm/Tacstd2^tm1Lsm Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0009932	skin fibrosis	"invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺,Pdgfra^tm12Sor/Pdgfra⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL
MP:0010273	increased classified tumor incidence	"greater than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Tg(Tyr-cre/ERT,-Hras1,-Trap1a)10BJvde/0 Genetic Background:* involves: C57BL/6 * FVB/N
MP:0010275	increased melanoma incidence	"greater than the expected number of malignant neoplasms, derived from melanocytes and occuring in pigmented tissues, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Mt1-HGFSF)19Lmb/0 Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh,X/Tg(Tyr-HRAS)60Lc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,X/Tg(Tyr-HRAS)60Lc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB Allelic Composition: Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Braf^tm1Cpri/Braf^tm1Cpri,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-BRAFV600E)470Fgh/0 Genetic Background:* involves: 129/Sv * C57BL/6J * CBA * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-BRAFV600E)476Fgh/0 Genetic Background:* involves: 129/Sv * C57BL/6J * CBA * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Pten^tm1Rps/Pten^tm1Rps,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt,Pten^tm1Rps/Pten^tm1Rps,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53⁺,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,X/Tg(Tyr-HRAS)60Lc Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Pten^tm1Rdp/Pten^tm1Rdp,Tg(tetO-BRAFV600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background:* involves: 129/Sv * C57BL/6J * FVB * SJL
MP:0010276	increased intraocular melanoma incidence	"greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the uvea of the eye, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,X/Tg(Tyr-HRAS)60Lc Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * FVB/N * SJL
MP:0010278	increased glioma incidence	"greater than the expected number of tumors that arise from glial cells, non-neuronal cells of the nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(S100b-v-erbB)4496Waw/0 Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Tg(S100b-v-erbB)4496Waw/0 Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(GFAP-TVA)10Ech/0 Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Tg(GFAP-TVA)5Hev/0 Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(GFAP-TVA)5Hev/0 Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(GFAP-TVA)5Hev/0 Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0010300	increased skin tumor incidence	"greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Cdkn2b^tm2Brn/Cdkn2b^tm2Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Braf^tm1Cpri/Braf^tm1Cpri,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL
MP:0010301	increased stomach tumor incidence	"greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp,Kras^tm4Tyj/Kras⁺,Smad4^tm1Rdp/Smad4^tm1Rdp,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
MP:0010308	decreased tumor latency	"earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St6gal1^tm1Jlau/St6gal1^tm1Jlau Genetic Background: B6.129S4-St6gal1^tm1Jlau Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(S100b-v-erbB)4496Waw/0 Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL
MP:0010309	increased mesothelioma incidence	"greater than the expected number of neoplasms derived from the lining cells of the pleura and peritoneum, in a specific population in a given time period; is composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a⁺,Nf2^tm2Gth/Nf2^tm2Gth,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0010310	increased Schwannoma incidence	"greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; usually associated with a peripheral or cranial nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0010311	increased meningioma incidence	"greater than the expected number of encapsulated neoplasms derived from the meninges, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth,Ptgds^{tm1.1(cre)Gvn}/Ptgds⁺ Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0010312	increased oligodendroglioma incidence	"greater than the expected number of encapsulated neoplasms derived from oligodendrocytes, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(S100b-v-erbB)4496Waw/0 Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Tg(GFAP-TVA)5Hev/0 Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(GFAP-TVA)5Hev/0 Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(GFAP-TVA)5Hev/0 Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Tg(NES-TVA)J12Ech/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0010313	increased osteoma incidence	"greater than the expected number of benign neoplasms derived from lamellar bone, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0010322	increased cutaneous melanoma incidence	"greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the skin, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-NRASQ61K)1Bee/? Genetic Background:* involves: 129/Sv * C57BL/6 * DBA/2 * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Tg(Tyr-NRASQ61K)1Bee/? Genetic Background:* involves: 129/Sv * C57BL/6 * DBA/2 * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(Tyr-NRASQ61K)1Bee/0 Genetic Background:* involves: 129/Sv * C57BL/6J * DBA/2 * SJL Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn,Tg(Tyr-cre/ERT,-Hras1,-Trap1a)10BJvde/0 Genetic Background:* involves: C57BL/6 * FVB/N Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Nras^tm1Tyj/Nras^tm1Tyj,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: B6J.Cg-Nras^tm1Tyj Cdkn2a^tm2.1Nesh Tg(Tyr-cre/ERT2)13Bos Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Nras^tm1.1Nesh/Nras^tm1.1Nesh,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: B6J.Cg-Nras^tm1.1Nesh Cdkn2a^tm2.1Nesh Tg(Tyr-cre/ERT2)13Bos Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: B6J.Cg-Cdkn2a^tm2.1Nesh Kras^tm4Tyj Tg(Tyr-cre/ERT2)13Bos Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Nras^tm1.1Nesh/Nras^tm1.1Nesh,Stk11^tm1.1Rdp/Stk11^tm1.1Rdp,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: B6J.Cg-Nras^tm1.1Nesh Cdkn2a^tm2.1Nesh Stk11^tm1.1Rdp Tg(Tyr-cre/ERT2)13Bos Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Tg(tetO-NrasQ61K)#Lc/0,Tg(Tyr-rtTA)37Lc/0 Genetic Background:* FVB.Cg-Cdkn2a^tm1Rdp Tg(tetO-Nras*Q61K)#Lc Tg(Tyr-rtTA)37Lc
MP:0010334	pleural effusion	"accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a⁺,Nf2^tm2Gth/Nf2^tm2Gth,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0010336	increased acute lymphoblastic leukemia incidence		Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^em1Cjs/Cdkn2a^em1Cjs Genetic Background: B6.Cg-Cdkn2a^em1Cjs
MP:0010347	osseous metaplasia	"the formation of mature bone elements in the stroma of a neoplasm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Nf2^tm2Gth/Nf2^tm2Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0010363	increased fibrosarcoma incidence	"greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺,Pdgfra^tm12Sor/Pdgfra⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL
MP:0010367	increased spindle cell carcinoma incidence	"greater than the expected number of a highly malignant variant of squamous cell carcinoma, occurring in a specific population in a given time period; spindle cell carcinoma shows biphasic proliferation of conventional SCC component and malignant spindle shape cells with sarcomatous appearance" [PMID:19040765]	Show Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Kras^tm4Tyj/Kras⁺,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a⁺,Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53⁺,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tacstd2^tm1Lsm/Tacstd2^tm1Lsm Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010711	persistent hyperplastic primary vitreous	"persistence of the embryonic fibrovascular mesodermal tissue located between the optic cup and lens vesicle that normally regresses during the development of the vitreous body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: FVB.Cg-Cdkn2a^tm1Rdp Allelic Composition: Cdkn2a^em2Cjs/Cdkn2a^em2Cjs Genetic Background: C57BL/6-Cdkn2a^em2Cjs
MP:0010727	increased glioblastoma incidence	"greater than the expected number of a fast-growing type of central nervous system tumor that forms from glial tissue of the brain and spinal cord and has cells that look very different from normal cells; glioblastoma usually occurs in adults and affects the brain more often than the spinal cord" [NCI:CDRID45698 "http://www.cancer.gov/dictionary/?CdrID=45698"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm1(CAG-EGFR)Char},Pten^tm1Hwu/Pten^tm1Hwu Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Col1a1^{tm2(CAG-EGFR)Char}/Col1a1^{tm2(CAG-EGFR)Char},Pten^tm1Hwu/Pten^tm1Hwu Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm2(CAG-EGFR)Char},Pten^tm1Hwu/Pten^tm1Hwu Genetic Background:* involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
MP:0010741	abnormal melanocyte proliferation	"anomaly in the ability of the a melanocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Nras^tm1Tyj/Nras^tm1Tyj,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: B6J.Cg-Nras^tm1Tyj Cdkn2a^tm2.1Nesh Tg(Tyr-cre/ERT2)13Bos Allelic Composition: Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh,Nras^tm1.1Nesh/Nras^tm1.1Nesh,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background: B6J.Cg-Nras^tm1.1Nesh Cdkn2a^tm2.1Nesh Tg(Tyr-cre/ERT2)13Bos
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Lig4^tm1Fwa/Lig4^tm1Fwa Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Lig4^tm1Fwa/Lig4^tm1Fwa Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pknox1^tm1Fbla/Pknox1^tm1Fbla,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011703	increased fibroblast proliferation	"greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cav1^tm1Mls/Cav1^tm1Mls,Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0011748	intestinal fibrosis	"formation of fibrous tissue in any part of the intestine as a result of repair or a reactive process" [MGI:csmith]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺,Pdgfra^tm12Sor/Pdgfra⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL
MP:0012193	increased keratinocyte migration	"increased or faster movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]	Show Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Tacstd2^tm1Lsm/Tacstd2^tm1Lsm Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c^tm1Sje Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)76Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs,Sclt1^{Tg(CAG-sb10)1Dla}/0,TgTn(sb-T2/Onc)68Dla/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Terc^tm1Rdp/Terc^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Rnf2^tm1Mvi/Rnf2^tm1Mvi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Genetic Background: involves: 129S6/SvEvTac * FVB/N

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