19225


Mus musculus (NCBI)
regulationprocesscellresponseactivitybiosyntheticstressproliferationgrowthfactorproductionapoptoticbindingprostaglandinmetabolicdifferentiationsynapticproteinsmoothmuscleangiogenesisfattyacidbloodpathwaytransmissionnucleusinvolvedcontractionbrown

Features
Gene ID: 19225
  
Biological name :
  
Synonyms : COX2|Cox-2|PES-2|PGHS-2|PHS II|PHS-2|Pghs2|TIS10|gripghs / prostaglandin-endoperoxide synthase 2 / Ptgs2
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1417262_at (Mouse Genome 430 2.0 Array)   1417263_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 31981525
RefSeq - NC_000067.6
RefSeq - NP_035328.2
RefSeq - NM_011198.4
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000032487 to get all the annotations available for this gene.


Gene Ontology (GO)
biosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processanatomical structure developmentresponse to stressmulti-multicellular organism processsystem processregulation of biological qualitycytokine productioncell deathcellular developmental processossificationmulticellular organism reproductionresponse to external stimuluscell communicationresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processmacromolecule localizationestablishment of localizationcellular localizationregulation of molecular functioncell cyclemuscle cell proliferationoxidation-reduction processcellular response to stimulusresponse to abiotic stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processanatomical structure developmentresponse to stressmulti-multicellular organism processsystem processregulation of biological qualitycytokine productioncell deathcellular developmental processossificationmulticellular organism reproductionresponse to external stimuluscell communicationresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processmacromolecule localizationestablishment of localizationcellular localizationregulation of molecular functioncell cyclemuscle cell proliferationoxidation-reduction processcellular response to stimulusresponse to abiotic stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processanatomical structure developmentresponse to stressmulti-multicellular organism processsystem processregulation of biological qualitycytokine productioncell deathcellular developmental processossificationmulticellular organism reproductionresponse to external stimuluscell communicationresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processmacromolecule localizationestablishment of localizationcellular localizationregulation of molecular functioncell cyclemuscle cell proliferationoxidation-reduction processcellular response to stimulusresponse to abiotic stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processanatomical structure developmentresponse to stressmulti-multicellular organism processsystem processregulation of biological qualitycytokine productioncell deathcellular developmental processossificationmulticellular organism reproductionresponse to external stimuluscell communicationresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processmacromolecule localizationestablishment of localizationcellular localizationregulation of molecular functioncell cyclemuscle cell proliferationoxidation-reduction processcellular response to stimulusresponse to abiotic stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processanatomical structure developmentresponse to stressmulti-multicellular organism processsystem processregulation of biological qualitycytokine productioncell deathcellular developmental processossificationmulticellular organism reproductionresponse to external stimuluscell communicationresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processmacromolecule localizationestablishment of localizationcellular localizationregulation of molecular functioncell cyclemuscle cell proliferationoxidation-reduction processcellular response to stimulusresponse to abiotic stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processanatomical structure developmentresponse to stressmulti-multicellular organism processsystem processregulation of biological qualitycytokine productioncell deathcellular developmental processossificationmulticellular organism reproductionresponse to external stimuluscell communicationresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processmacromolecule localizationestablishment of localizationcellular localizationregulation of molecular functioncell cyclemuscle cell proliferationoxidation-reduction processcellular response to stimulusresponse to abiotic stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processanatomical structure developmentresponse to stressmulti-multicellular organism processsystem processregulation of biological qualitycytokine productioncell deathcellular developmental processossificationmulticellular organism reproductionresponse to external stimuluscell communicationresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processmacromolecule localizationestablishment of localizationcellular localizationregulation of molecular functioncell cyclemuscle cell proliferationoxidation-reduction processcellular response to stimulusresponse to abiotic stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processanatomical structure developmentresponse to stressmulti-multicellular organism processsystem processregulation of biological qualitycytokine productioncell deathcellular developmental processossificationmulticellular organism reproductionresponse to external stimuluscell communicationresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processmacromolecule localizationestablishment of localizationcellular localizationregulation of molecular functioncell cyclemuscle cell proliferationoxidation-reduction processcellular response to stimulusresponse to abiotic stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processanatomical structure developmentresponse to stressmulti-multicellular organism processsystem processregulation of biological qualitycytokine productioncell deathcellular developmental processossificationmulticellular organism reproductionresponse to external stimuluscell communicationresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processmacromolecule localizationestablishment of localizationcellular localizationregulation of molecular functioncell cyclemuscle cell proliferationoxidation-reduction processcellular response to stimulusresponse to abiotic stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processanatomical structure developmentresponse to stressmulti-multicellular organism processsystem processregulation of biological qualitycytokine productioncell deathcellular developmental processossificationmulticellular organism reproductionresponse to external stimuluscell communicationresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processmacromolecule localizationestablishment of localizationcellular localizationregulation of molecular functioncell cyclemuscle cell proliferationoxidation-reduction processcellular response to stimulusresponse to abiotic stimuluslocalization of cellmovement of cell or subcellular componenttissue migrationbiosbiosynthetic processcellcellular metabolic processprimprimary metabolic processsmalsmall molecule metabolic processorgaorganic substance metabolic processanatanatomical structure developmentrespresponse to stressmultmulti-multicellular organism processsystsystem processreguregulation of biological qualitycytocytokine productioncellcell deathcellcellular developmental processossiossificationmultmulticellular organism reproductionrespresponse to external stimuluscellcell communicationrespresponse to chemicalrespresponse to biotic stimulusnitrnitrogen compound metabolic processmacrmacromolecule localizationestaestablishment of localizationcellcellular localizationreguregulation of molecular functioncellcell cyclemuscmuscle cell proliferationoxidoxidation-reduction processcellcellular response to stimulusrespresponse to abiotic stimuluslocalocalization of cellmovemovement of cell or subcellular componenttisstissue migration
oxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingion bindingoxidoreductase activityoxidoreductase activityprotein bindingprotein bindingorganic cyclic compoundorganic cyclic compound bindingheterocyclic compound bheterocyclic compound bindingcofactor bindingcofactor bindingion bindingion binding
cellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process ISO
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0006954 inflammatory response ISO
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007566 embryo implantation ISO
 biological_processGO:0007612 learning ISO
 biological_processGO:0007613 memory ISO
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production ISO
 biological_processGO:0010942 positive regulation of cell death ISO
 biological_processGO:0019233 sensory perception of pain ISO
 biological_processGO:0019371 cyclooxygenase pathway ISO
 biological_processGO:0030216 keratinocyte differentiation NAS
 biological_processGO:0030282 bone mineralization ISO
 biological_processGO:0030728 ovulation ISO
 biological_processGO:0031394 positive regulation of prostaglandin biosynthetic process IMP
 biological_processGO:0031622 positive regulation of fever generation ISO
 biological_processGO:0031915 positive regulation of synaptic plasticity ISO
 biological_processGO:0032227 negative regulation of synaptic transmission, dopaminergic ISO
 biological_processGO:0032496 response to lipopolysaccharide ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0034097 response to cytokine ISO
 biological_processGO:0035633 maintenance of permeability of blood-brain barrier ISO
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042307 positive regulation of protein import into nucleus ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISO
 biological_processGO:0045786 negative regulation of cell cycle ISO
 biological_processGO:0045907 positive regulation of vasoconstriction ISO
 biological_processGO:0045986 negative regulation of smooth muscle contraction ISO
 biological_processGO:0045987 positive regulation of smooth muscle contraction ISO
 biological_processGO:0046697 decidualization ISO
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISO
 biological_processGO:0050873 brown fat cell differentiation IMP
 biological_processGO:0051926 negative regulation of calcium ion transport ISO
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071471 cellular response to non-ionic osmotic stress IMP
 biological_processGO:0071498 cellular response to fluid shear stress IDA
 biological_processGO:0071636 positive regulation of transforming growth factor beta production ISO
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis ISO
 biological_processGO:0090271 positive regulation of fibroblast growth factor production ISO
 biological_processGO:0090336 positive regulation of brown fat cell differentiation IMP
 biological_processGO:0090362 positive regulation of platelet-derived growth factor production ISO
 biological_processGO:0097756 negative regulation of blood vessel diameter ISO
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005901 caveola ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex ISO
 cellular_componentGO:0043005 neuron projection ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004666 prostaglandin-endoperoxide synthase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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