ENSMUSG00000032487


Mus musculus

Features
Gene ID: ENSMUSG00000032487
  
Biological name :Ptgs2
  
Synonyms : Prostaglandin G/H synthase 2 / Ptgs2 / Q05769
  
Possible biological names infered from orthology : P35354 / prostaglandin-endoperoxide synthase 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: G1
Gene start: 150100031
Gene end: 150108227
  
Corresponding Affymetrix probe sets: 10350516 (MoGene1.0st)   1417262_at (Mouse Genome 430 2.0 Array)   1417263_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139904
Ensembl peptide - ENSMUSP00000035065
NCBI entrez gene - 19225     See in Manteia.
MGI - MGI:97798
RefSeq - NM_011198
RefSeq Peptide - NP_035328
swissprot - A0A087WPT2
swissprot - Q05769
Ensembl - ENSMUSG00000032487
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgs2aENSDARG00000004539Danio rerio
 ptgs2bENSDARG00000010276Danio rerio
 PTGS2ENSGALG00000033635Gallus gallus
 PTGS2ENSG00000073756Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptgs1 / P22437 / prostaglandin-endoperoxide synthase 1 / P23219*ENSMUSG0000004725062


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR010255  Haem peroxidase
 IPR019791  Haem peroxidase, animal type
 IPR029576  Prostaglandin G/H synthase 2
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009750 response to fructose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010042 response to manganese ion IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019371 cyclooxygenase pathway IEA
 biological_processGO:0030216 keratinocyte differentiation NAS
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030728 ovulation IEA
 biological_processGO:0031394 positive regulation of prostaglandin biosynthetic process IMP
 biological_processGO:0031622 positive regulation of fever generation IEA
 biological_processGO:0031915 positive regulation of synaptic plasticity IEA
 biological_processGO:0032227 negative regulation of synaptic transmission, dopaminergic IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035633 maintenance of permeability of blood-brain barrier IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042633 hair cycle IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045986 negative regulation of smooth muscle contraction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050873 brown fat cell differentiation IMP
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051926 negative regulation of calcium ion transport IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071284 cellular response to lead ion IEA
 biological_processGO:0071318 cellular response to ATP IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071471 cellular response to non-ionic osmotic stress IMP
 biological_processGO:0071498 cellular response to fluid shear stress IDA
 biological_processGO:0071636 positive regulation of transforming growth factor beta production IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0090271 positive regulation of fibroblast growth factor production IEA
 biological_processGO:0090336 positive regulation of brown fat cell differentiation IMP
 biological_processGO:0090362 positive regulation of platelet-derived growth factor production IEA
 biological_processGO:0097756 negative regulation of blood vessel diameter IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IMP
 biological_processGO:1990776 response to angiotensin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004666 prostaglandin-endoperoxide synthase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Biosynthesis of DHA-derived SPMs
Biosynthesis of EPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hrhr/Hrhr,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SKH1

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Apctm1Mmt/Apc+,Ptgs2tm1Jed/Ptgs2+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apctm1Mmt/Apc+,Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Chl1tm1Mtg/Chl1tm1Mtg
Genetic Background: B6.129P2-Chl1tm1Mtg

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001422 abnormal drinking behavior "an altered pattern of fluid consumption or altered preference for particular fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2-Ptgs2tm1Unc

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptgs2tm2(Ptgs1)Fun/Ptgs2tm2(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2-Ptgs2tm1Unc

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: ApcMin/Apc+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: ApcMin/Apc+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hrhr/Hrhr,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SKH1

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm2(Ptgs1)Fun/Ptgs2tm2(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm2(Ptgs1)Fun/Ptgs2tm2(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2-Ptgs2tm1Unc

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpc3tm1Arge/Gpc3+,Igf2tm1Rob/Igf2+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Ptgs2tm3Fun/Ptgs2tm3Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm3Fun/Ptgs2tm3Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002735 abnormal chemical nociception "abnormal capability to sense pain elicited by chemical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Chl1tm1Mtg/Chl1tm1Mtg
Genetic Background: B6.129P2-Chl1tm1Mtg

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0003075 response to CNS ischemic injury 
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0003139 patent ductus arteriosus "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0003177 decreased pain threshold "ordinarily painless stimuli, once perceived, are experienced as being painful" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:81734]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apctm1Mmt/Apc+,Ptgs2tm1Jed/Ptgs2+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003299 gastric polyps "abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ptgs2tm1Jed/Ptgs2+,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003357 impaired granulosa cell differentiation "atypical differentiation of the layer of small cells that forms the wall of an ovarian follicle" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43075]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003422 abnormal thrombolysis "altered ability to break up (lyse) blood clots that are restricting the blood flow" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:17427]
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Allelic Composition: Ptgs2tm1Fun/Ptgs2tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003426 pulmonary interstitial fibrosis "formation of fibrous tissue within the interstices of the lung as a result of repair or a reactive process" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:63134]
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Allelic Composition: Lbric/Lbr+
Genetic Background: Not Specified

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003626 kidney medulla hypoplasia 
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003829 impaired febrile response "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1.1Wls/Ptgs2tm1.1Wls
Genetic Background: B6.129-Ptgs2tm1.1Wls

 MP:0003845 abnormal decidualization "disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0004155 resistance to induced pancreatitis "reduced or absent inflammatory response in the pancreatic tissue after experimental manipulation" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004504 decreased incidence of UV-induced tumors "lower than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrhr/Hrhr,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SKH1

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0004867 decreased platelet calcium level "decreased concentration in the platelet of this bivalent element" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * CD-1

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Fun/Ptgs2tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Ptgs2tm3Fun/Ptgs2tm3Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptgs2tm1Fun/Ptgs2tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Ptgs2tm3Fun/Ptgs2tm3Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0005656 decreased aggression "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Fun/Ptgs2tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008004 abnormal stomach pH "anomaly in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, as measured by the concentration of the hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lbric/Lbr+
Genetic Background: Not Specified

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ptgs2tm1Jed/Ptgs2+,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: ApcMin/Apc+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008095 abnormal memory B cell differentiation "atypical production of or inability to produce distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm2.1Hahe
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1.1Wls/Ptgs2tm1.1Wls
Genetic Background: B6.129-Ptgs2tm1.1Wls

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lbric/Lbr+
Genetic Background: Not Specified

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0009148 pancreas necrosis "pathological cell death in the pancreas, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009373 abnormal cumulus expansion "defective or reduced ability of the cumulus cells to synthesize and accumulate hyaluronan into an extracellular matrix (ECM), which provides an essential microenvironment for oocyte fertilization; this expanded ECM binds the oocyte and the cumulus cells together, protects the oocyte from the proteolytic and mechanical stresses during extrusion, and allows sperm binding, penetration, and fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009548 abnormal platelet aggregation "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Ptgs2tm3Fun/Ptgs2tm3Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm3Fun/Ptgs2tm3Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6;129P2-Ptgs2tm1Unc/Tac

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm2.1Hahe
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Fun/Ptgs2tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: ApcMin/Apc+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6.129P2-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6;129P2-Ptgs2tm1Unc/Tac

Allelic Composition: Hrhr/Hrhr,Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SKH1

 MP:0010985 abnormal kidney mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptgs2tm2(Ptgs1)Fun/Ptgs2tm2(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011290 decreased nephron number "reduction in the total number of filtering units of the kidney" [MGI:anna]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6;129P2-Ptgs2tm1Unc/Tac

 MP:0011308 kidney corticomedullary cysts "development of abnormal membranous sacs in the corticomedullary junction of the kidney" [MGI:anna]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0011334 abnormal nephrogenic zone morphology "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011352 proximal convoluted tubule brush border loss "attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes" [MGI:anna]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011376 abnormal kidney corticomedullary boundary morphology "any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011383 abnormal kidney capsule morphology "any structural anomaly of the tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage" [MGI:anna]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011403 pyelonephritis "a diffuse pyogenic infection of the pelvis and parenchyma of the kidney; an ascending urinary tract infection that has reached the pyelum or pelvis of the kidney usually resulting from noncontagious bacterial infection of the bladder" [MGI:anna]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011408 renal tubule hypertrophy "increase in the bulk size of the loop of Henle, the proximal convoluted tubule or the distal convoluted tubule, due to cell enlargement" [MGI:anna]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011423 kidney cortex atrophy "acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011534 granular kidney "a kidney in which fairly uniform, diffusely and evenly situated foci of scarring of the interstitial tissue of the cortex (and sometimes scarring of glomeruli), and the associated slight degree of bulging of groups of dilated tubules, leads to the development of a minutely bosselated surface; such kidneys are seen in arteriolar nephrosclerosis or chronic glomerulonephritis" [MGI:anna]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

 MP:0011563 increased urine prostaglandin level "a greater amount of any prostaglandin in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Ptgs2tm1.1Wls/Ptgs2tm1.1Wls
Genetic Background: B6.129-Ptgs2tm1.1Wls

 MP:0011564 decreased urine prostaglandin level "a reduced amount of any prostaglandin in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Ptgs2tm1Fun/Ptgs2tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0011682 renal glomerulus cysts "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2(B6J)-Ptgs2tm1Unc

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012008 delayed parturition "the process of labor and delivery in female animals occurs later in gestation than expected or lack of progress in a labor already initiated" [MGI:csmith]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0012737 abnormal primary polar body morphology "any structural anomaly of the small cell formed by the first meiotic division of oocytes" [MGI:anna]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013237 abnormal skeletal muscle regeneration "anomaly in the ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6;129P2-Ptgs2tm1Unc/Tac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032487 Ptgs2 / Q05769 / Prostaglandin G/H synthase 2 / P35354* / prostaglandin-endoperoxide synthase 2*  / complex






 

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contact: otassy@igbmc.fr