ENSMUSG00000047250


Mus musculus

Features
Gene ID: ENSMUSG00000047250
  
Biological name :Ptgs1
  
Synonyms : P22437 / prostaglandin-endoperoxide synthase 1 / Ptgs1
  
Possible biological names infered from orthology : P23219
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 36230426
Gene end: 36252272
  
Corresponding Affymetrix probe sets: 10471721 (MoGene1.0st)   1423414_at (Mouse Genome 430 2.0 Array)   1436448_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059977
NCBI entrez gene - 19224     See in Manteia.
MGI - MGI:97797
RefSeq - XM_017316496
RefSeq - NM_008969
RefSeq - XM_006497791
RefSeq - XM_006497794
RefSeq - XM_011239036
RefSeq - XM_006497790
RefSeq Peptide - NP_032995
swissprot - P22437
swissprot - Q543T1
Ensembl - ENSMUSG00000047250
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgs1ENSDARG00000052148Danio rerio
 PTGS1ENSGALG00000001314Gallus gallus
 PTGS1ENSG00000095303Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptgs2 / Q05769 / Prostaglandin G/H synthase 2 / P35354* / prostaglandin-endoperoxide synthase 2*ENSMUSG0000003248762


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR010255  Haem peroxidase
 IPR019791  Haem peroxidase, animal type
 IPR029580  Prostaglandin G/H synthase 1
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0019371 cyclooxygenase pathway ISO
 biological_processGO:0030216 keratinocyte differentiation NAS
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004666 prostaglandin-endoperoxide synthase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
COX reactions
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: B6.129P2-Ptgs1tm1Unc

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp3mldy/Casp3mldy
Genetic Background: either: C3H.B6-Casp3mldy or (involves: C3H/HeH * C57BL/6J)

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hrhr/Hrhr,Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SKH1

 MP:0000505 reduced digestive secretion "decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6;129P2-Ptgs2tm1Unc/Tac

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001422 abnormal drinking behavior "an altered pattern of fluid consumption or altered preference for particular fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: B6;129P2-Ptgs1tm1Unc/Tac

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs1tm1Fun/Ptgs1tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: B6.129P2-Ptgs1tm1Unc

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: B6.129P2-Ptgs1tm1Unc

 MP:0002907 abnormal parturition "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cnr1tm1Zim/Cnr1tm1Zim,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0003139 patent ductus arteriosus "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003177 decreased pain threshold "ordinarily painless stimuli, once perceived, are experienced as being painful" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:81734]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: B6.129P2-Ptgs1tm1Unc

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: B6.129P2-Ptgs1tm1Unc

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: B6.129P2-Ptgs1tm1Unc

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004014 abnormal uterine environment "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: B6.129P2-Ptgs2tm1Unc

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0005186 increased circulating progesterone level "greater than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs1tm1Fun/Ptgs1tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005527 increased glomerular filtration rate "greater than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0005531 increased renal vascular resistance "greater than the normal force opposing blood flow in the kidney blood vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ptgs1tm1Fun/Ptgs1tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Casp3mldy/Casp3mldy
Genetic Background: either: C3H.B6-Casp3mldy or (involves: C3H/HeH * C57BL/6J)

 MP:0008004 abnormal stomach pH "anomaly in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, as measured by the concentration of the hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: B6;129P2-Ptgs2tm1Unc/Tac

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0008800 increased small intestinal crypt cell apoptosis "increase in the number of small intestinal crypt cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: B6;129P2-Ptgs1tm1Unc/Tac

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: B6.129P2-Ptgs1tm1Unc

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: D1.129P2-Ptgs2tm1Unc

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hrhr/Hrhr,Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SKH1

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0009818 abnormal thromboxane level 
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Allelic Composition: Ptgs1tm1Fun/Ptgs1tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011021 abnormal circadian regulation of heart rate "anomaly in the process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours" [GO:0003053]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0011022 abnormal circadian regulation of systemic arterial blood pressure "any anomaly in the process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours" [GO:0003052]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0011564 decreased urine prostaglandin level "a reduced amount of any prostaglandin in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs1tm1Fun/Ptgs1tm1Fun
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012008 delayed parturition "the process of labor and delivery in female animals occurs later in gestation than expected or lack of progress in a labor already initiated" [MGI:csmith]
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Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012124 increased bronchoconstrictive response "enhanced or greater than expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography" [MGI:csmith]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: B6.129P2-Ptgs1tm1Unc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000047250 Ptgs1 / P22437 / prostaglandin-endoperoxide synthase 1 / P23219*  / complex






 

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