ENSG00000095303


Homo sapiens

Features
Gene ID: ENSG00000095303
  
Biological name :PTGS1
  
Synonyms : P23219 / prostaglandin-endoperoxide synthase 1 / PTGS1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q33.2
Gene start: 122370530
Gene end: 122395703
  
Corresponding Affymetrix probe sets: 205127_at (Human Genome U133 Plus 2.0 Array)   205128_x_at (Human Genome U133 Plus 2.0 Array)   215813_s_at (Human Genome U133 Plus 2.0 Array)   238669_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494717
Ensembl peptide - ENSP00000484800
Ensembl peptide - ENSP00000495728
Ensembl peptide - ENSP00000223423
Ensembl peptide - ENSP00000354612
Ensembl peptide - ENSP00000362802
Ensembl peptide - ENSP00000411606
Ensembl peptide - ENSP00000437709
Ensembl peptide - ENSP00000483540
NCBI entrez gene - 5742     See in Manteia.
OMIM - 176805
RefSeq - XM_017014929
RefSeq - NM_000962
RefSeq - NM_001271164
RefSeq - NM_001271165
RefSeq - NM_001271166
RefSeq - NM_001271367
RefSeq - NM_001271368
RefSeq - NM_080591
RefSeq - XM_005252105
RefSeq - XM_011518875
RefSeq - XM_011518876
RefSeq Peptide - NP_001258095
RefSeq Peptide - NP_001258296
RefSeq Peptide - NP_001258297
RefSeq Peptide - NP_542158
RefSeq Peptide - NP_000953
RefSeq Peptide - NP_001258093
RefSeq Peptide - NP_001258094
swissprot - P23219
swissprot - X6RJD6
swissprot - A0A087X296
Ensembl - ENSG00000095303
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgs1ENSDARG00000052148Danio rerio
 PTGS1ENSGALG00000001314Gallus gallus
 Ptgs1ENSMUSG00000047250Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTGS2 / P35354 / prostaglandin-endoperoxide synthase 2ENSG0000007375661


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR010255  Haem peroxidase
 IPR019791  Haem peroxidase, animal type
 IPR029580  Prostaglandin G/H synthase 1
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process ISS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0008217 regulation of blood pressure ISS
 biological_processGO:0019371 cyclooxygenase pathway IDA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004601 peroxidase activity TAS
 molecular_functionGO:0004666 prostaglandin-endoperoxide synthase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
COX reactions
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000095303 PTGS1 / P23219 / prostaglandin-endoperoxide synthase 1  / complex






 

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