ENSG00000073756


Homo sapiens

Features
Gene ID: ENSG00000073756
  
Biological name :PTGS2
  
Synonyms : P35354 / prostaglandin-endoperoxide synthase 2 / PTGS2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q31.1
Gene start: 186671791
Gene end: 186680427
  
Corresponding Affymetrix probe sets: 1554997_a_at (Human Genome U133 Plus 2.0 Array)   204748_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356438
Ensembl peptide - ENSP00000454130
NCBI entrez gene - 5743     See in Manteia.
OMIM - 600262
RefSeq - NM_000963
RefSeq Peptide - NP_000954
swissprot - P35354
swissprot - Q6ZYK7
Ensembl - ENSG00000073756
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgs2aENSDARG00000004539Danio rerio
 ptgs2bENSDARG00000010276Danio rerio
 PTGS2ENSGALG00000033635Gallus gallus
 Ptgs2ENSMUSG00000032487Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTGS1 / P23219 / prostaglandin-endoperoxide synthase 1ENSG0000009530361


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR010255  Haem peroxidase
 IPR019791  Haem peroxidase, animal type
 IPR029576  Prostaglandin G/H synthase 2
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009750 response to fructose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010042 response to manganese ion IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019371 cyclooxygenase pathway IEA
 biological_processGO:0019372 lipoxygenase pathway TAS
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030728 ovulation IEA
 biological_processGO:0031394 positive regulation of prostaglandin biosynthetic process NAS
 biological_processGO:0031622 positive regulation of fever generation IEA
 biological_processGO:0031915 positive regulation of synaptic plasticity IEA
 biological_processGO:0032227 negative regulation of synaptic transmission, dopaminergic IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035633 maintenance of permeability of blood-brain barrier IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042633 hair cycle IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045986 negative regulation of smooth muscle contraction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050727 regulation of inflammatory response NAS
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051926 negative regulation of calcium ion transport IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071284 cellular response to lead ion IEA
 biological_processGO:0071318 cellular response to ATP IEA
 biological_processGO:0071456 cellular response to hypoxia IEP
 biological_processGO:0071471 cellular response to non-ionic osmotic stress IEA
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:0071636 positive regulation of transforming growth factor beta production IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0090271 positive regulation of fibroblast growth factor production ISS
 biological_processGO:0090336 positive regulation of brown fat cell differentiation IEA
 biological_processGO:0090362 positive regulation of platelet-derived growth factor production IEA
 biological_processGO:0097756 negative regulation of blood vessel diameter IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IEA
 biological_processGO:1990776 response to angiotensin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004666 prostaglandin-endoperoxide synthase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050473 arachidonate 15-lipoxygenase activity TAS
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Biosynthesis of DHA-derived SPMs
Biosynthesis of EPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000073756 PTGS2 / P35354 / prostaglandin-endoperoxide synthase 2  / complex






 

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