ENSDARG00000004539


Danio rerio

Features
Gene ID: ENSDARG00000004539
  
Biological name :ptgs2a
  
Synonyms : prostaglandin-endoperoxide synthase 2a / ptgs2a
  
Possible biological names infered from orthology : P35354 / prostaglandin-endoperoxide synthase 2 / Prostaglandin G/H synthase 2 / PTGS2 / Q05769
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 20916497
Gene end: 20923864
  
Corresponding Affymetrix probe sets: Dr.1082.1.S1_at (Zebrafish Array)   NM_153657_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000022450
NCBI entrez gene - 246227     See in Manteia.
RefSeq - NM_153657
RefSeq Peptide - NP_705943
swissprot - Q6P4V3
ZFIN ID - ZDB-GENE-020530-2
Ensembl - ENSDARG00000004539
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTGS2ENSGALG00000033635Gallus gallus
 PTGS2ENSG00000073756Homo sapiens
 Ptgs2ENSMUSG00000032487Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptgs2b / prostaglandin-endoperoxide synthase 2b / PTGS2* / Q05769* / P35354* / Prostaglandin G/H synthase 2 * / prostaglandin-endoperoxide synthase 2*ENSDARG0000001027672
ptgs1 / prostaglandin-endoperoxide synthase 1 / P22437* / P23219*ENSDARG0000005214858


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR010255  Haem peroxidase
 IPR019791  Haem peroxidase, animal type
 IPR029576  Prostaglandin G/H synthase 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0019371 cyclooxygenase pathway IEA
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1990402 embryonic liver development IMP
 molecular_functionGO:0004601 peroxidase activity IDA
 molecular_functionGO:0004666 prostaglandin-endoperoxide synthase activity IEA
 molecular_functionGO:0020037 heme binding IEA


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Biosynthesis of DHA-derived SPMs
Biosynthesis of EPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain ventricular system edematous , abnormal
Show

 ZFA:0000123 liver liver amount , ameliorated
liver size , ameliorated
liver decreased size , abnormal
liver decreased distribution , abnormal
Show

 ZFA:0000166 lateral crista lateral crista has fewer parts of type lateral crista kinocilium, abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas amount , ameliorated
exocrine pancreas size , ameliorated
exocrine pancreas decreased size , abnormal
exocrine pancreas decreased distribution , abnormal
Show

 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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