ENSGALG00000033635


Gallus gallus

Features
Gene ID: ENSGALG00000033635
  
Biological name :PTGS2
  
Synonyms : P27607 / Prostaglandin G/H synthase 2 / PTGS2
  
Possible biological names infered from orthology : P35354 / prostaglandin-endoperoxide synthase 2 / Q05769
  
Species: Gallus gallus
  
Chr. number: 8
Strand: 1
Band:
Gene start: 9902170
Gene end: 9910762
  
Corresponding Affymetrix probe sets: Gga.14323.1.S1_at (Chicken Array)   Gga.4401.1.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050135
Ensembl peptide - ENSGALP00000054904
Ensembl peptide - ENSGALP00000054566
Ensembl peptide - ENSGALP00000047422
NCBI entrez gene - 396451     See in Manteia.
RefSeq - NM_001167719
RefSeq - NM_001167718
RefSeq Peptide - NP_001161190
RefSeq Peptide - NP_001161191
swissprot - P27607
swissprot - A0A1D5PBK5
swissprot - A0A1D5P416
Ensembl - ENSGALG00000033635
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgs2aENSDARG00000004539Danio rerio
 ptgs2bENSDARG00000010276Danio rerio
 PTGS2ENSG00000073756Homo sapiens
 Ptgs2ENSMUSG00000032487Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTGS1 / prostaglandin-endoperoxide synthase 1 / P22437* / P23219*ENSGALG0000000131463


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR010255  Haem peroxidase
 IPR019791  Haem peroxidase, animal type
 IPR029576  Prostaglandin G/H synthase 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0019371 cyclooxygenase pathway IEA
 biological_processGO:0031394 positive regulation of prostaglandin biosynthetic process IEA
 biological_processGO:0031622 positive regulation of fever generation IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071471 cellular response to non-ionic osmotic stress IEA
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:0090336 positive regulation of brown fat cell differentiation IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004666 prostaglandin-endoperoxide synthase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Biosynthesis of DHA-derived SPMs
Biosynthesis of EPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000033635 PTGS2 / P27607 / Prostaglandin G/H synthase 2 / Q05769* / P35354* / prostaglandin-endoperoxide synthase 2*  / complex






 

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