5743


Homo sapiens (NCBI)

Features
Gene ID: 5743
  
Biological name :
  
Synonyms : COX-2|COX2|GRIPGHS|PGG/HS|PGHS-2|PHS-2|hCox-2 / prostaglandin-endoperoxide synthase 2 / PTGS2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1554997_a_at (Human Genome U133 Plus 2.0 Array)   204748_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 4506265
RefSeq - NC_000001.11
RefSeq - NG_028206.2
RefSeq - NP_000954.1
RefSeq - NM_000963.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000073756 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process NAS
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0008217 regulation of blood pressure ISS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009750 response to fructose IEA
 biological_processGO:0010042 response to manganese ion IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019371 cyclooxygenase pathway TAS
 biological_processGO:0019372 lipoxygenase pathway TAS
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030728 ovulation IEA
 biological_processGO:0031394 positive regulation of prostaglandin biosynthetic process NAS
 biological_processGO:0031622 positive regulation of fever generation ISS
 biological_processGO:0031915 positive regulation of synaptic plasticity IEA
 biological_processGO:0032227 negative regulation of synaptic transmission, dopaminergic IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035633 maintenance of permeability of blood-brain barrier IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042633 hair cycle IEA
 biological_processGO:0042759 long-chain fatty acid biosynthetic process TAS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISS
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045986 negative regulation of smooth muscle contraction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050727 regulation of inflammatory response NAS
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051926 negative regulation of calcium ion transport IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071284 cellular response to lead ion IEA
 biological_processGO:0071318 cellular response to ATP IEA
 biological_processGO:0071456 cellular response to hypoxia IEP
 biological_processGO:0071471 cellular response to non-ionic osmotic stress IEA
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:0071636 positive regulation of transforming growth factor beta production ISS
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis ISS
 biological_processGO:0090271 positive regulation of fibroblast growth factor production ISS
 biological_processGO:0090336 positive regulation of brown fat cell differentiation ISS
 biological_processGO:0090362 positive regulation of platelet-derived growth factor production ISS
 biological_processGO:0097756 negative regulation of blood vessel diameter IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IEA
 biological_processGO:1990776 response to angiotensin IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0004601 peroxidase activity TAS
 molecular_functionGO:0004666 prostaglandin-endoperoxide synthase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0020037 heme binding ISS
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050473 arachidonate 15-lipoxygenase activity TAS


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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