20472


Mus musculus (NCBI)
bindingmorphogenesisregulationtranscriptioncelldnadevelopmentsequence-specificmesenchymalrnapolymeraseiidifferentiationinvolvedproliferationfactoractivitychondrocyteembryonicnephronmetanephroskidneydna-templatedproteinnucleusspecificationstemcomplexproximalpromoter

Features
Gene ID: 20472
  
Biological name :
  
Synonyms : sine oculis-related homeobox 2 / Six2
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1427436_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - XP_011244637.1
RefSeq - 568999581
RefSeq - 755556229
RefSeq - NC_000083.6
RefSeq - NP_035510.1
RefSeq - XP_006523994.1
RefSeq - 33859628
RefSeq - NM_011380.2
RefSeq - XM_011246335.2
RefSeq - XM_006523931.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000024134 to get all the annotations available for this gene.


Gene Ontology (GO)
anatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmacromolecule localizationestablishment of localizationcellular localizationlocalization of cellmovement of cell or subcellular componentossificationmaintenance of cell numbermesenchymal cell proliferationstem cell proliferationchondrocyte proliferationanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmacromolecule localizationestablishment of localizationcellular localizationlocalization of cellmovement of cell or subcellular componentossificationmaintenance of cell numbermesenchymal cell proliferationstem cell proliferationchondrocyte proliferationanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmacromolecule localizationestablishment of localizationcellular localizationlocalization of cellmovement of cell or subcellular componentossificationmaintenance of cell numbermesenchymal cell proliferationstem cell proliferationchondrocyte proliferationanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmacromolecule localizationestablishment of localizationcellular localizationlocalization of cellmovement of cell or subcellular componentossificationmaintenance of cell numbermesenchymal cell proliferationstem cell proliferationchondrocyte proliferationanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmacromolecule localizationestablishment of localizationcellular localizationlocalization of cellmovement of cell or subcellular componentossificationmaintenance of cell numbermesenchymal cell proliferationstem cell proliferationchondrocyte proliferationanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmacromolecule localizationestablishment of localizationcellular localizationlocalization of cellmovement of cell or subcellular componentossificationmaintenance of cell numbermesenchymal cell proliferationstem cell proliferationchondrocyte proliferationanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmacromolecule localizationestablishment of localizationcellular localizationlocalization of cellmovement of cell or subcellular componentossificationmaintenance of cell numbermesenchymal cell proliferationstem cell proliferationchondrocyte proliferationanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmacromolecule localizationestablishment of localizationcellular localizationlocalization of cellmovement of cell or subcellular componentossificationmaintenance of cell numbermesenchymal cell proliferationstem cell proliferationchondrocyte proliferationanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmacromolecule localizationestablishment of localizationcellular localizationlocalization of cellmovement of cell or subcellular componentossificationmaintenance of cell numbermesenchymal cell proliferationstem cell proliferationchondrocyte proliferationanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmacromolecule localizationestablishment of localizationcellular localizationlocalization of cellmovement of cell or subcellular componentossificationmaintenance of cell numbermesenchymal cell proliferationstem cell proliferationchondrocyte proliferationanatomicanatomical structure developmentcellularcellular developmental processnitrogennitrogen compound metabolic processbiosynthbiosynthetic processcellularcellular metabolic processprimary primary metabolic processorganic organic substance metabolic processmacromolmacromolecule localizationestablisestablishment of localizationcellularcellular localizationlocalizalocalization of cellmovementmovement of cell or subcellular componentossificaossificationmaintenamaintenance of cell numbermesenchymesenchymal cell proliferationstem celstem cell proliferationchondrocchondrocyte proliferation
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingprotein-containing complex bindingorganic cyclic compound bindorganic cyclic compound bindingheterocyclic compound bindinheterocyclic compound bindingDNA-binding transcription faDNA-binding transcription factor activityprotein bindingprotein bindingprotein-containing complex bprotein-containing complex binding
cellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellcellorganelleorganelleprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001822 kidney development ISO
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006606 protein import into nucleus IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007501 mesodermal cell fate specification IDA
 biological_processGO:0008283 cell proliferation ISO
 biological_processGO:0009948 anterior/posterior axis specification IDA
 biological_processGO:0016477 cell migration ISO
 biological_processGO:0030278 regulation of ossification IMP
 biological_processGO:0032330 regulation of chondrocyte differentiation IMP
 biological_processGO:0042474 middle ear morphogenesis IGI
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IGI
 biological_processGO:0048856 anatomical structure development IBA
 biological_processGO:0072006 nephron development IMP
 biological_processGO:0072028 nephron morphogenesis IMP
 biological_processGO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis IMP
 biological_processGO:0072137 condensed mesenchymal cell proliferation IGI
 biological_processGO:0072161 mesenchymal cell differentiation involved in kidney development IMP
 biological_processGO:0090189 regulation of branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0097168 mesenchymal stem cell proliferation IMP
 biological_processGO:1902732 positive regulation of chondrocyte proliferation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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