ENSMUSG00000024134


Mus musculus

Features
Gene ID: ENSMUSG00000024134
  
Biological name :Six2
  
Synonyms : Homeobox protein SIX2 / Q62232 / Six2
  
Possible biological names infered from orthology : Q9NPC8 / SIX homeobox 2
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E4
Gene start: 85684277
Gene end: 85688274
  
Corresponding Affymetrix probe sets: 10453394 (MoGene1.0st)   1427436_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024947
Ensembl peptide - ENSMUSP00000125871
NCBI entrez gene - 20472     See in Manteia.
MGI - MGI:102778
RefSeq - XM_006523931
RefSeq - NM_011380
RefSeq Peptide - NP_035510
swissprot - Q62232
Ensembl - ENSMUSG00000024134
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 six2aENSDARG00000058004Danio rerio
 six2bENSDARG00000054878Danio rerio
 SIX2ENSGALG00000023303Gallus gallus
 SIX2ENSG00000170577Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Six1 / Q62231 / Homeobox protein SIX1 / Q15475* / SIX homeobox 1*ENSMUSG0000005136774
Six4 / Q61321 / Homeobox protein SIX4 / Q9UIU6* / SIX homeobox 4*ENSMUSG0000003446051
Six5 / P70178 / Homeobox protein SIX5 / Q8N196* / SIX homeobox 5*ENSMUSG0000004084148
Six6 / Q9QZ28 / sine oculis-related homeobox 6 / O95475* / SIX homeobox 6*ENSMUSG0000002109948
Six3 / Q62233 / Homeobox protein SIX3 / O95343* / SIX homeobox 3*ENSMUSG0000003880547


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR031701  Homeobox protein SIX1, N-terminal SD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001822 kidney development ISS
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006606 protein import into nucleus IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007501 mesodermal cell fate specification IDA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0009948 anterior/posterior axis specification IDA
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0030278 regulation of ossification IMP
 biological_processGO:0032330 regulation of chondrocyte differentiation IMP
 biological_processGO:0042474 middle ear morphogenesis IGI
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IGI
 biological_processGO:0072006 nephron development IMP
 biological_processGO:0072028 nephron morphogenesis IMP
 biological_processGO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis IMP
 biological_processGO:0072137 condensed mesenchymal cell proliferation IGI
 biological_processGO:0072161 mesenchymal cell differentiation involved in kidney development IMP
 biological_processGO:0090189 regulation of branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0097168 mesenchymal stem cell proliferation IMP
 biological_processGO:1902732 positive regulation of chondrocyte proliferation IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000524 reduced renal tubule number "fewer loops of Henle and collecting ducts" [J:40203]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

Allelic Composition: Wasltm2Sbs/Wasltm2Sbs,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

Allelic Composition: Six2tm1Gco/Six2tm1Gco
Genetic Background: involves: 129X1/SvJ * C57BL/6J * NMRI

Allelic Composition: Six2tm1Gco/Six2tm1Gco,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6J * NMRI

Allelic Composition: Six2tm1Gco/Six2tm1Gco
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Six2tm1Gco/Six2tm1Gco,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Six2tm1Gco/Six2tm1Gco,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6J

 MP:0000533 kidney hemorrhage "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1.1Rsmi/Apc+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Six2tm2(cre/ERT2)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Six2tm3(EGFP/cre/ERT2)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1(Sall1)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0003014 abnormal kidney medulla morphology "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wasltm2Sbs/Wasltm2Sbs,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003624 anuria "inability to form or excrete urine" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

Allelic Composition: Wasltm2Sbs/Wasltm2Sbs,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004755 abnormal loop of Henle "any structural anomaly of the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

Allelic Composition: Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2tm1(tTA,tetO-EGFP/cre)Amc
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Six2tm2(cre/ERT2)Amc/Six2tm2(cre/ERT2)Amc
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Six2tm3(EGFP/cre/ERT2)Amc/Six2tm3(EGFP/cre/ERT2)Amc
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0011289 abnormal nephron number "anomaly in the total number of the filtering units of the kidney; nephron number can be used as an index of the efficiency of ureteric branching and nephrogenesis" [MGI:anna]
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Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

 MP:0011334 abnormal nephrogenic zone morphology "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011363 renal glomerulus atrophy "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0011364 abnormal metanephros morphology "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0011371 decreased kidney apoptosis "decrease in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0011387 absent metanephric mesenchyme "absence of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing metanephros; normally, interactions between the ureteric bud and the metanephric mesenchyme lead to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:anna]
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0011457 abnormal metanephric ureteric bud development "any anomaly in the development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros" [GO:0035502]
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0011682 renal glomerulus cysts "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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