ENSMUSG00000040841


Mus musculus

Features
Gene ID: ENSMUSG00000040841
  
Biological name :Six5
  
Synonyms : Homeobox protein SIX5 / P70178 / Six5
  
Possible biological names infered from orthology : Q8N196 / SIX homeobox 5
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 19094594
Gene end: 19098549
  
Corresponding Affymetrix probe sets: 10550593 (MoGene1.0st)   1427560_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045973
NCBI entrez gene - 20475     See in Manteia.
MGI - MGI:106220
RefSeq - NM_011383
RefSeq - XM_006539694
RefSeq Peptide - NP_035513
swissprot - P70178
Ensembl - ENSMUSG00000040841
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 six5ENSDARG00000068406Danio rerio
 SIX5ENSG00000177045Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Six4 / Q61321 / Homeobox protein SIX4 / Q9UIU6* / SIX homeobox 4*ENSMUSG0000003446032
Six2 / Q62232 / Homeobox protein SIX2 / Q9NPC8* / SIX homeobox 2*ENSMUSG0000002413420
Six3 / Q62233 / Homeobox protein SIX3 / O95343* / SIX homeobox 3*ENSMUSG0000003880518
Six1 / Q62231 / Homeobox protein SIX1 / Q15475* / SIX homeobox 1*ENSMUSG0000005136718
Six6 / Q9QZ28 / sine oculis-related homeobox 6 / O95475* / SIX homeobox 6*ENSMUSG0000002109917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR031701  Homeobox protein SIX1, N-terminal SD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1902723 negative regulation of skeletal muscle satellite cell proliferation IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: 129S4/SvJae-Six5tm1Rdd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: 129S4/SvJae-Six5tm1Rdd

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: 129S4/SvJae-Six5tm1Rdd

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

Allelic Composition: Six5tm1Rdd/Six5tm1Rdd
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Six5tm1Tap/Six5+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: 129S4/SvJae-Six5tm1Rdd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: 129S4/SvJae-Six5tm1Rdd

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

 MP:0005250 Sertoli cell hypoplasia "decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:70212]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Foxn1nu/Foxn1nu,Tg(Foxn1)G2Hon/0
Genetic Background: involves: CD-1

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: 129S4/SvJae-Six5tm1Rdd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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