ENSMUSG00000021099


Mus musculus

Features
Gene ID: ENSMUSG00000021099
  
Biological name :Six6
  
Synonyms : Q9QZ28 / sine oculis-related homeobox 6 / Six6
  
Possible biological names infered from orthology : O95475 / SIX homeobox 6
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 72939892
Gene end: 72944899
  
Corresponding Affymetrix probe sets: 10396367 (MoGene1.0st)   1419408_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021519
NCBI entrez gene - 20476     See in Manteia.
MGI - MGI:1341840
RefSeq - NM_011384
RefSeq Peptide - NP_035514
swissprot - B2RSE8
swissprot - Q9QZ28
Ensembl - ENSMUSG00000021099
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 six6aENSDARG00000025187Danio rerio
 six6bENSDARG00000031316Danio rerio
 SIX6ENSGALG00000020359Gallus gallus
 SIX6ENSG00000184302Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Six3 / Q62233 / Homeobox protein SIX3 / O95343* / SIX homeobox 3*ENSMUSG0000003880581
Six2 / Q62232 / Homeobox protein SIX2 / Q9NPC8* / SIX homeobox 2*ENSMUSG0000002413458
Six1 / Q62231 / Homeobox protein SIX1 / Q15475* / SIX homeobox 1*ENSMUSG0000005136756
Six5 / P70178 / Homeobox protein SIX5 / Q8N196* / SIX homeobox 5*ENSMUSG0000004084150
Six4 / Q61321 / Homeobox protein SIX4 / Q9UIU6* / SIX homeobox 4*ENSMUSG0000003446048


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR031701  Homeobox protein SIX1, N-terminal SD domain
 IPR032947  Homeobox protein SIX6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0001333 absent optic nerve "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0002659 pituitary gland hypoplasia "decreased size of pituitary gland due to decreased cell number" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pax610Neu/Pax610Neu
Genetic Background: involves: 102 * C3H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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