ENSMUSG00000051367


Mus musculus

Features
Gene ID: ENSMUSG00000051367
  
Biological name :Six1
  
Synonyms : Homeobox protein SIX1 / Q62231 / Six1
  
Possible biological names infered from orthology : Q15475 / SIX homeobox 1
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 73040015
Gene end: 73053887
  
Corresponding Affymetrix probe sets: 10400967 (MoGene1.0st)   1427277_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059026
NCBI entrez gene - 20471     See in Manteia.
MGI - MGI:102780
RefSeq - NM_009189
RefSeq Peptide - NP_033215
swissprot - Q3V2C3
swissprot - Q62231
Ensembl - ENSMUSG00000051367
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 six1aENSDARG00000039304Danio rerio
 six1bENSDARG00000026473Danio rerio
 SIX1ENSGALG00000029401Gallus gallus
 SIX1ENSG00000126778Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Six2 / Q62232 / Homeobox protein SIX2 / Q9NPC8* / SIX homeobox 2*ENSMUSG0000002413477
Six4 / Q61321 / Homeobox protein SIX4 / Q9UIU6* / SIX homeobox 4*ENSMUSG0000003446051
Six6 / Q9QZ28 / sine oculis-related homeobox 6 / O95475* / SIX homeobox 6*ENSMUSG0000002109948
Six3 / Q62233 / Homeobox protein SIX3 / O95343* / SIX homeobox 3*ENSMUSG0000003880548
Six5 / P70178 / Homeobox protein SIX5 / Q8N196* / SIX homeobox 5*ENSMUSG0000004084145


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR031278  Homeobox protein SIX1
 IPR031701  Homeobox protein SIX1, N-terminal SD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001657 ureteric bud development IMP
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IGI
 biological_processGO:0001759 organ induction IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0003151 outflow tract morphogenesis IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008582 regulation of synaptic growth at neuromuscular junction IGI
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation IDA
 biological_processGO:0021610 facial nerve morphogenesis IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030855 epithelial cell differentiation IMP
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0030910 olfactory placode formation IMP
 biological_processGO:0032880 regulation of protein localization IGI
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0035909 aorta morphogenesis IGI
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0042474 middle ear morphogenesis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043586 tongue development IMP
 biological_processGO:0045664 regulation of neuron differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048513 animal organ development IEA
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048665 neuron fate specification IGI
 biological_processGO:0048699 generation of neurons IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IGI
 biological_processGO:0048704 embryonic skeletal system morphogenesis IGI
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0048856 anatomical structure development IGI
 biological_processGO:0050678 regulation of epithelial cell proliferation IMP
 biological_processGO:0051451 myoblast migration IGI
 biological_processGO:0060037 pharyngeal system development IGI
 biological_processGO:0061055 myotome development IMP
 biological_processGO:0061197 fungiform papilla morphogenesis IMP
 biological_processGO:0061551 trigeminal ganglion development IMP
 biological_processGO:0071599 otic vesicle development IMP
 biological_processGO:0072001 renal system development IGI
 biological_processGO:0072075 metanephric mesenchyme development IMP
 biological_processGO:0072095 regulation of branch elongation involved in ureteric bud branching IMP
 biological_processGO:0072107 positive regulation of ureteric bud formation IMP
 biological_processGO:0072172 mesonephric tubule formation IMP
 biological_processGO:0072193 ureter smooth muscle cell differentiation IMP
 biological_processGO:0072513 positive regulation of secondary heart field cardioblast proliferation IGI
 biological_processGO:0090103 cochlea morphogenesis IMP
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0090191 negative regulation of branching involved in ureteric bud morphogenesis IMP
 biological_processGO:1905243 cellular response to 3,3",5-triiodo-L-thyronine IEA
 biological_processGO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development IGI
 biological_processGO:2001014 regulation of skeletal muscle cell differentiation IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IGI
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0000033 absent cochlear duct "missing spiral tube within the cochlea; contains the neuroepithelial receptor organ for hearing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Ckmtm1Bew/Ckmtm2Bew
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000036 absent semicircular canals "missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0000090 absent premaxilla "missing anterior and interior portion of the maxilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prnptm2Rcm/Prnptm2Rcm
Genetic Background: Not Specified

Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000430 absent maxillary shelf "missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Six1tm2.2Mair/Six1tm2.2Mair
Genetic Background: involves: C57BL/6NTac

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Bcl6tm1.1Jwan/Bcl6tm1.1Jwan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-Six1Cwe

Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Bcl6tm1.1Jwan/Bcl6tm1.1Jwan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akap9repro12/Akap9tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cmn3C57BL/6J/?,Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prnptm2Rcm/Prnptm2Rcm
Genetic Background: Not Specified

Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0002235 abnormal external nares morphology "any structural anomaly of the anterior opening to the nasal cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002237 abnormal nasal cavity morphology "any structural anomaly of the portion of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0002280 abnormal intercostal muscle morphology "anomaly in the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Tacstd2tm1Lsm/Tacstd2tm1Lsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002659 pituitary gland hypoplasia "decreased size of pituitary gland due to decreased cell number" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002729 abnormal canal morphology "any anomaly or malformation of the tubular ducts of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Ckmtm1Bew/Ckmtm2Bew
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0002858 abnormal posterior semicircular canal "anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Tbx1tm1Bem/Tbx1tm1Bem
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002990 short ureter "reduced length of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003069 abnormal superior semicircular canal "anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0003090 abnormal muscle progenitor cell migration "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0003108 short zygomatic bone "reduced length of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0003142 anotia "congenital absence of one or both auricles of the ears" [J:57313, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0003147 absent cochlea "absence or agenesis of the cochlea" [J:23837, J:36834, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003161 absent lateral semicircular canal 
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Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0003162 reduced size of lateral semicircular canal 
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003164 reduced size of posterior semicircular canal 
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003166 reduced size of superior semicircular canal 
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003358 abnormal hypaxial muscle morphology "malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0003604 single kidney 
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Fgf8tm1.3Mrt/Fgf8+,Six1tm1(cre,ALPP)Xli/Six1+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004161 cervical aortic arch "aortic arch is located above the level of the clavicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8+,Six1tm1(cre,ALPP)Xli/Six1+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0004204 absent stapes "absence of the smallest and innermost of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004248 abnormal epaxial muscle morphology "any structural anomaly of the muscles derived from the medial myotome; includes the intrinsic back muscles" [PMID:1591996]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0004313 absent vestibulocochlear ganglion "absence of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004314 absent vestibule "absence of the cavity between the semicircular canals and the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004317 small saccule "reduced size of the cavity between the semicircular canals and the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0004318 absent incus "absence of the middle of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0004336 small utricle "reduced size of the larger of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0004396 decreased cochlear inner hair cell number "decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0004422 small temporal bone "reduced size of the large, irregular bone located at the base and side of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004439 absent Meckel s cartilage "absence of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004467 absent zygomatic bone "absence of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004473 absent nasal bone "absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004666 absent stapedial artery "absence of the small artery that passes through the ring of the stapes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004699 unilateral deafness "bilateral asymmetry in auditory function whereby one of the two ears displays auditory thresholds indicative of intact hearing while the other ear displays thresholds reflecting auditory dysfunction " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0004739 conductive hearing loss "progressive hearing loss due to lesions in the external auditory canal or middle ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004873 absent turbinates "absence of the small curved bones that extend horizontally along the lateral wall of the nasal passage" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0004922 abnormal common crus morphology "any structural abnormality in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005106 abnormal incus morphology "structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005107 abnormal stapes morphology "structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005247 abnormal extraocular muscle morphology "structural anomaly of any of the striated muscles that move the eye and include: superior rectus, inferrior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005499 abnormal olfactory system morphology "anomalous structure of the organs involved in smell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0006011 abnormal endolymphatic duct morphology "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006012 dilated endolymphatic duct "an expansion in the volume of the endolymphatic duct" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072:]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006018 abnormal tympanic membrane morphology "any structural alterations in the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane consitutes the boundary between the external and middle ear." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:46639:]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Fgf8tm1.3Mrt/Fgf8+,Six1tm1(cre,ALPP)Xli/Six1+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0006211 small orbits "reduced size of the orbits" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0006284 absent hypaxial muscle "absence of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue" [J:86619, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0006285 absent inner ear "absence of all components of the labyrinth, including the semicircular canals, vestibule and cochlea" [J:86619, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006286 inner ear hypoplasia "underdevelopment or reduced size of inner ear structures, usually due to decreased cell number" [J:83662, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0006288 small otic capsule "reduced size of the cartilage or bony capsule surrounding the inner ear mechanism" [J:59285, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0008023 abnormal styloid process morphology "any structural abnormality in the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0008064 decreased otic epithelium proliferation "reduction in the expansion rate of the otic epithelial cell population by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0008065 short endolymphatic duct "length reduction or truncation of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0008321 small adenohypophysis "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Rsd/Six1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008429 absent parotid gland "absence of the largest of the major salivary glands situated below and in front of each ear and opening into the parotid duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0008430 short squamosal bone "length reduction of the thin, platelike part of the temporal bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0008488 abnormal semicircular canal ampulla morphology "any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Six1tm2.1Mair/Six1tm2.1Mair,Pax7tm1(cre/ERT2)Gaka/Pax7+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6Cr * C57BL/6NTac

 MP:0009520 decreased submandibular gland size "reduced size of either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0009913 abnormal hyoid bone greater horn morphology "any structural anomaly of the larger and more lateral of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0010466 vascular ring "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0011366 absent metanephros "absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0011883 absent diaphragm "absence of the thin musculomebranous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [MGI:Colin_McKerlie]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0012729 abnormal common carotid artery morphology "any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012754 abnormal cranial neural crest cell morphology "any structural anomaly of the neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [http://discovery.lifemapsc.com/in-vivo-development/neural-crest/cranial-neural-crest, http://embryology.med.unsw.edu.au/embryology/index.php?title=Neural_Crest_Development#Cranial_neural_crest, http://en.wikipedia.org/wiki/Cranial_neural_crest, MGI:anna]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0013127 epistaxis "hemorrhage from the nose, usually apparent when the blood drains out through the nostrils" [MGI:Ahmad_Retha, MGI:csmith]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013300 abnormal submandibular gland physiology "any functional anomaly of either of the large major salivary glands situated beneath the mandible" [MGI:Anna]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013331 abnormal lacrimal gland development "aberrant formation or incomplete differentiation of the paired almond-shaped glands, one for each eye, that secrete the aqueous layer of the tear film; each lacrimal gland develops through branching morphogenesis regulated by FGF signaling; at E12.5, the conjunctival epithelium at the temporal side of the mouse eyes invades the Fgf10-expressing mesenchyme to form the initial lacrimal gland bud; the bud elongates posteriorly until E15.5 when secondary branching begins to establish the complex tubuloalveolar structure; this eventually gives rise to the mature lacrimal gland composed of numerous ducts, acini and connective tissue" [MGI:Anna, PMID:22745308]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0013541 abnormal submandibular gland development "aberrant formation or incomplete differentiation of either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible; in mice, submandibular gland development initiates as a thickening of the oral epithelium; around E12 an initial (single) epithelial bud on a stalk grows into a condensing neural crest-derived mesenchyme; clefts in the epithelium result in 3-5 epithelial buds at E13.5, and branching morphogenesis occurs with continued proliferation, successive rounds of cleft formation, duct elongation, and duct lumen formation, so that by E14 the gland is highly branched (multi-lobed); functional differentiation, with the appearance of proacinar cells and secretory products begins after E15 and continues to birth; acinar differentiation continues postnatally with final differentiation of the granular convoluted tubules at puberty" [MGI:Anna, PMID:17336109]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013595 absent vomeronasal organ "lacking the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system" [MGI:csmith]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013929 absent eye muscles 
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0013964 absent tongue muscles 
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0014155 absent olfactory epithelium "absence of the epithelial cells that line the interior of the nose" [MGI:csmith]
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Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030095 abnormal midface morphology "any structural anomaly of the midface region which extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base; it is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region; traditionally, the nose and premaxilla are not included in the midface" [HP:0000309, PMID:19125436]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030208 abnormal intrinsic tongue muscle morphology "any structural anomaly of any of the four paired muscles that originate and insert within the tongue, running along its length; these muscles alter the shape of the tongue by lengthening and shortening it, curling and uncurling its apex and edges, and flattening and rounding its surface; they include the superior longitudinal muscle, the inferior longitudinal muscle, the vertical muscle, and the transverse muscle" [https://en.wikipedia.org/wiki/Tongue, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Muscles-of-tongue, MGI:anna]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0030210 abnormal genioglossus muscle morphology "any structural anomaly of the paired, fan-shaped extrinsic tongue muscle which forms the majority of the body of the tongue, arises from the mental spine of the mandible and inserts into the hyoid bone and the bottom of the tongue; its action protracts and depresses the tongue" [https://en.wikipedia.org/wiki/Genioglossus, MGI:anna]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0030313 abnormal face development "any anomaly in the process in which the anatomical structures of the face are generated and organized" [GO:0060325]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030421 tongue muscle hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the muscular portion of the tongue" [MGI:anna]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030426 facial muscle hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of any of the striated skeletal muscles innervated by the facial nerve (cranial nerve VII) that, among other things, control facial expression" [MGI:anna]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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