ENSDARG00000026473


Danio rerio

Features
Gene ID: ENSDARG00000026473
  
Biological name :six1b
  
Synonyms : Q6NZ04 / six1b / SIX homeobox 1b
  
Possible biological names infered from orthology : Homeobox protein SIX1 / Q15475 / Q62231 / SIX1 / SIX homeobox 1
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 20499869
Gene end: 20505918
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000028379
NCBI entrez gene - 404627     See in Manteia.
swissprot - Q6NZ04
ZFIN ID - ZDB-GENE-040426-2308
Ensembl - ENSDARG00000026473
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SIX1ENSGALG00000029401Gallus gallus
 SIX1ENSG00000126778Homo sapiens
 Six1ENSMUSG00000051367Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
six1a / Q6DHF9 / SIX homeobox 1a / SIX1* / Q62231* / Q15475* / SIX homeobox 1* / Homeobox protein SIX1 *ENSDARG0000003930489
six2a / SIX homeobox 2a / SIX2* / Q9NPC8* / Q62232* / SIX homeobox 2* / Homeobox protein SIX2 *ENSDARG0000005800476
six2b / SIX homeobox 2b / SIX2* / Q9NPC8* / Q62232* / SIX homeobox 2* / Homeobox protein SIX2 *ENSDARG0000005487873
six9 / SIX homeobox 9ENSDARG0000006840751
six4a / SIX homeobox 4a / SIX4* / Q9UIU6* / Q61321* / SIX homeobox 4* / Homeobox protein SIX4 *ENSDARG0000000469549
six6a / SIX homeobox 6a / SIX6* / Q9QZ28* / O95475* / SIX homeobox 6* / sine oculis-related homeobox 6*ENSDARG0000002518749
six3a / SIX homeobox 3a / SIX3* / Q62233* / O95343* / SIX homeobox 3* / Homeobox protein SIX3 *ENSDARG0000005800848
six6b / SIX homeobox 6b / SIX6* / Q9QZ28* / O95475* / SIX homeobox 6* / sine oculis-related homeobox 6*ENSDARG0000003131648
six4b / SIX homeobox 4b / SIX4* / Q9UIU6* / Q61321* / SIX homeobox 4* / Homeobox protein SIX4 *ENSDARG0000003198347
six3b / SIX homeobox 3b / SIX3* / Q62233* / O95343* / SIX homeobox 3* / Homeobox protein SIX3 *ENSDARG0000005487947
six7 / SIX homeobox 7ENSDARG0000007010745
six5 / SIX homeobox 5 / P70178* / Q8N196* / Homeobox protein SIX5 *ENSDARG0000006840642


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR031278  Homeobox protein SIX1
 IPR031701  Homeobox protein SIX1, N-terminal SD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002074 extraocular skeletal muscle development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0014857 regulation of skeletal muscle cell proliferation IMP
 biological_processGO:0021984 adenohypophysis development IGI
 biological_processGO:0043282 pharyngeal muscle development IMP
 biological_processGO:0048513 animal organ development IEA
 biological_processGO:0048741 skeletal muscle fiber development IGI
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0048935 peripheral nervous system neuron development IMP
 biological_processGO:0051146 striated muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite U-shaped , abnormal
somite fast muscle cell disorganized , abnormal
somite cell proliferation decreased occurrence , abnormal
Show

 ZFA:0000301 medial rectus medial rectus aplastic , abnormal
Show

 ZFA:0000328 cephalic musculature cephalic musculature skeletal muscle tissue development decreased process quality , abnormal
Show

 ZFA:0000457 ventral rectus ventral rectus aplastic , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature refractivity , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch muscle aplastic , abnormal
Show

 ZFA:0001651 sternohyoid sternohyoid aplastic , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell apoptotic process increased process quality , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell muscle fiber development decreased process quality , abnormal
fast muscle cell shape , abnormal
fast muscle cell myofibril position , abnormal
Show

 ZFA:0009204 prolactin secreting cell prolactin secreting cell decreased amount , abnormal
Show

 ZFA:0009205 melanocyte stimulating hormone secreting cell melanocyte stimulating hormone secreting cell decreased amount , abnormal
melanocyte stimulating hormone secreting cell absent , abnormal
Show

 ZFA:0009216 adrenocorticotropic hormone secreting cell adrenocorticotropic hormone secreting cell decreased amount , abnormal
adrenocorticotropic hormone secreting cell absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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